@article{article_1673127, title={Glutathione S-transferase gene polymorphism, total antioxidant status, and blood pressure changes in androgenic alopecia}, journal={Anatolian Clinic the Journal of Medical Sciences}, volume={30}, pages={295–301}, year={2025}, DOI={10.21673/anadoluklin.1673127}, author={Şekerci, Abdüsselam and Bagci, Gokhan and Küçük Kurtulgan, Hande and Candan, Ferhan}, keywords={Androjenik alopesi, glutatyon S-transferaz, kan basıncı, oksidatif stres, polimorfizm}, abstract={Aim: To investigate the relationship of glutathione S-transferase gene polymorphism with total antioxidant capacity and blood pressure changes in patients with androgenic alopecia. Methods: Hamilton-Norwood classification was used for the diagnosis and staging of androgenic alopecia (AGA), and all individuals were evaluated by the same physician. Family history of AGA was questioned; body mass index (BMI), lipid profile, blood pressure (BP) levels, total oxidative stress (TOS), total antioxidant status (TAS), and glutathione S-transferase (GST) gene polymorphisms were evaluated. Polymerase chain reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) methods were used to detect GST polymorphisms. Blood pressure of the patients was measured by 24-hour ambulatory blood pressure monitoring. Results: The study included 43 male patients with a mean age of 35.09 ± 10.51 years and 90.6% of the individuals had a family history of AGA. When TOS, TAS, 24-hour BP measurement results (systolic-diastolic BP values) and dipper/nondipper BP status were compared according to GSTT1, GSTM1, GSTP1 I105V, GSTP1 A114V genotypes, the difference was not significant. However, TOS levels were higher in individuals with GSTP1 A114V heterozygous genotype (polymorphism detected) compared to individuals with the normal genotype. In addition, TAS was lower in individuals with GSTT1 null genotype (deletion in both alleles) compared to individuals with GSTT1 gene. Although the difference was not statistically significant, a positive correlation was observed between androgenic alopecia stages and the oxidative stress index (r=0.14). Conclusion: GST gene polymorphisms may be associated with increased oxidative stress and decreased total antioxidant capacity in patients with androgenic alopecia. Moreover, oxidative stress appears to increase with the progression of AGA stage.}, number={2}, publisher={Hayat Sağlık ve Sosyal Hizmetler Vakfı}, organization={Cumhuriyet University Scientific Research Projects Coordination Unit}