TY  - JOUR
T1  - Gama ile Işınlanmış Glisinamid Hidroklorür Toz Kristallerinin Elektron Paramanyetik Rezonans (EPR) İncelenmesi
TT  - Electron Paramagnetic Resonance (EPR) Study of Gamma-Irradiated Glycinamide Hydrochloride Powder Crystals
AU  - Başkan, Halim
PY  - 2025
DA  - July
Y2  - 2025
DO  - 10.58688/kujs.1678458
JF  - Kafkas Üniversitesi Fen Bilimleri Enstitüsü Dergisi
PB  - Kafkas Üniversitesi
WT  - DergiPark
SN  - 2587-2389
SP  - 1
EP  - 4
VL  - 18
IS  - 1
LA  - tr
AB  - Bu çalışmada, gama ışınları ile ışınlanmış Glisinamid Hidroklorür (GAHCl) toz kristallerinde oluşan serbest radikal yapılar, Elektron Paramanyetik Rezonans (EPR) spektroskopisi kullanılarak incelenmiştir. 20 kGy dozda ışınlanan örneğin EPR spektrumları kaydedilmiş ve ışınlama sonucu oluştuğu düşünülen H₂NĊHCONH₂ radikali tespit edilmiştir. Elde edilen EPR parametreleri (g-değeri: 2.0036, çizgi genişliği: 0.90 mT, aşırı ince yapı sabitleri: aCH = 1.23 mT, aN = 0.48 mT), simülasyon verileriyle uyumlu olup literatürdeki benzer glisin türevleriyle karşılaştırıldığında tutarlıdır. Ayrıca örneğin kimyasal ve biyolojik özellikleri kapsamlı bir şekilde araştırılmıştır. Bu sonuçlar, gama ışınlarının amino asit türevlerinde oluşturduğu yapısal değişikliklerin anlaşılması açısından önemli veriler sunmakta ve Glisinamid Hidroklorür’ün model bileşik olarak biyolojik ve farmasötik araştırmalarda kullanılabilirliğini göstermektedir.
KW  - Amino Asit  Türevi
KW  - Elektron Paramanyetik Rezonans
KW  - Serbest Radikal
N2  - In this study, free radical structures formed in gamma-irradiated Glycinamide Hydrochloride (GAHCl) powder crystals were investigated using Electron Paramagnetic Resonance (EPR) spectroscopy. EPR spectra of the sample irradiated with a dose of 20 kGy were recorded, and the H₂NĊHCONH₂ radical, presumed to have formed as a result of irradiation, was identified. The obtained EPR parameters (g-value: 2.0036, line width: 0.90 mT, hyperfine coupling constants: aCH = 1.23 mT, aN = 0.48 mT) were consistent with the simulation data and matched the values reported for similar glycine derivatives in the literature. Additionally, the chemical and biological properties of the sample were comprehensively investigated. These findings provide significant insights into the structural changes induced by gamma irradiation in amino acid derivatives and demonstrate the potential of Glycinamide Hydrochloride as a model compound in biological and pharmaceutical research.
CR  - Aydın, M., Osmanoğlu, Y.E., Başkan, M.H. (2008). Electron Paramagnetic Resonance of γ- Irradiated Glycyl-L-Glutamine Monohydrate, Iminodiacetic Acid and Methyliminodiacetic Acid,  Radiat. Eff. Defects Solids., 163: 47-53.
CR  - Aydin, M.(2011) The identity and structure of free radicals in γ-irradiated amino acid derivatives, Bulgarian Chemical Communications, 43: 419 – 422.
CR  - Başkan, M.H. (2008). EPR of γ -irradiated L-glutamine, glycyl-L-glutamine and N-glycyl-L-valine,  Radiat. Eff. Defects Solids, 163: 35-39.
CR  - Başkan, M.H., Aydın, M., Osmanoğlu, Ş., Topkaya, R.(2010). Electron paramagnetic resonance characterization of gamma irradiation damage centers in powder of L-(+)-tartaric acid, N-acetyl-L-alanine and 1-methyl-L-histidine, Radiation Effects and Defects in Solids: 165: 938-943.
CR  - Dicle, I.Y., Osmanoğlu, Ş., İpek, N. (2015). Electron paramagnetic resonance study of free radicals in γ-irradiated L-glutamine and L-Glutamine-t-butyl ester hydrochloride,  Radiat. Eff. Defects Solids., 170: 65-71. 
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CR  - Osmanoğlu, Y. E., Sütçü, K. (2023). Electron Spin Resonance Study of Free Radicals Induced in Single Crystal of Oxcarbazepine, App. Magnet. Resonan, 54(8): 751-759.
CR  - Osmanoğlu, Y.E. (2020). Simulation study of paramagnetic centers induced in glycine tertbutyl ester hydchkoride & L-α-alanine ethyl ester in solid state, El-Cezeri, J.Science and Engineering,  7(1): 262-266.
CR  - Osmanoğlu, Y.E., Sütçü, K., Osmanoğlu, Ş. (2017). Radiation Effect Studies on Some Glycine Derivatives in Solid State, Radiat. Eff. Defects Solids, 172: 621-628.
CR  - Sütçü, K. (2024). A Study to Identify and Analyze the Radiosensitivity of 4-Piperidinecarboxylic Acid Using Electron Paramagnetic Resonance Spectroscopy, App. Magnet. Resonan, 1-13.
CR  - Sütçü, K., Osmanoğlu, Y. E. (2023). Identification of free radicals formed in gamma-irradiated acetazolamide using electron paramagnetic resonance spectroscopy. Applied Magnetic Resonance, 54(8), 737-750.
Sütçü, K., Osmanoğlu, Y. E., Osmanoğlu, Ş. (2014). Effect of Irradiaiton Dose, Microwave Power, and Storage Time on the Free Radical Concentration in γ-Irradiated Black Olive (Olea europaea) Seeds. International J. Scien. Res. Innovat. Techno. 1(3): 21-29. 
Şimşek, R., Gündüz, M.G., Şafak, C.,  Kökpınar, Ö., Aydın, M.(2017).  Free radicals properties of some gamma-irradiated organic compounds,  Bulgarian Chemical Communications, 49:  82 – 86.
 Zincircioğlu, S.B,,Canoruç¸N.,¸ Osmanoğlu,Ş., Başkan, M.H., Dicle,I.Y.,  Aydın,M. (2006). Electron Paramagnetic Resonance of Some γ-Irradiated Amino Acid Derivatives, Radiat. Eff. Defects Solids., 61a: 577-582.
UR  - https://doi.org/10.58688/kujs.1678458
L1  - https://dergipark.org.tr/tr/download/article-file/4783435
ER  -