@article{article_1683309, title={IRISIN IN PREDICTING MAJOR ADVERSE CARDIAC EVENTS AFTER MYOCARDIAL INFARCTION IN OBESE HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS}, journal={Journal of Istanbul Faculty of Medicine}, volume={88}, pages={296–304}, year={2025}, DOI={10.26650/IUITFD.1683309}, author={Shelest, Borys and Avdieienko, Oleksandra and Sadovenko, Olga and Kalmykov, Oleksii and Rodionova, Iuliia and Babycheva, Oleksandra and Kovalova, Yuliia and Shelest, Oleksiy}, keywords={İrisin, miyokard enfarktüsü, hipertansiyon, obezite, diyabet mellitus}, abstract={Objective: Cardiovascular diseases (CVDs), particularly ST-elevation myocardial infarction (STEMI), remain the leading causes of mortality and disability worldwide. This study aimed to evaluate the relationship between serum irisin levels and the development of major adverse cardiovascular events (MACE) in high-risk patients with hypertension, type 2 diabetes mellitus (T2DM), and obesity following STEMI. Material and Methods: A prospective observational study included 238 hypertensive patients with T2DM and obesity (BMI>30 kg/m²) admitted with a first STEMI. Patients were divided into MACE (n=117) and non-MACE (n=121) groups. Serum irisin was measured by ELISA. MACE was assessed over 12 months and included recurrent myocardial infarction, stroke, cardiovascular death, and hospitalisation for heart failure. Results: Irisin levels were significantly lower in the MACE group (121.57±15.86 ng/mL) than in the non-MACE group (129.31±17.93 ng/ mL; p=0.0005). Patients with MACE had a significantly longer duration of hypertension and T2DM. A non-dipper blood pressure profile was more frequent in the MACE group (41.88% vs. 26.44%; p=0.0121). Multivariate logistic regression revealed that lower irisin levels (OR: 0.911; 95% CI: 0.417–0.991; p=0.041) and non-dipper BP profile were independent predictors of MACE. Conclusion: Lower irisin levels and abnormal circadian BP rhythm are associated with increased MACE risk after STEMI in patients with T2DM and obesity. Irisin may serve as a valuable biomarker for early risk stratification in such high-risk populations.}, number={4}, publisher={İstanbul Üniversitesi}