TY - JOUR T1 - Evaluation of body-mass index in patients with coronary artery ectasia TT - Evaluation of body-mass index in patients with coronary artery ectasia AU - Memioğlu, Tolga AU - İnanır, Mehmet AU - Dıramalı, Murat AU - Kiriş, Salih Vahit AU - Güven, İbrahim AU - Argana, Kıvanç AU - Toprak, Kenan AU - Özyaşar, Mehmet PY - 2025 DA - July Y2 - 2025 DO - 10.38053/acmj.1692331 JF - Anatolian Current Medical Journal JO - Anatolian Curr Med J / ACMJ / acmj PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2718-0115 SP - 404 EP - 409 VL - 7 IS - 4 LA - en AB - Aims: Coronary artery ectasia (CAE) is defined as the dilation of a coronary artery to at least 1.5 times the diameter of the adjacent normal segment, detected in 0.3%-5.3% of coronary angiographies. The body-mass index (BMI), calculated as weight (kg) divided by height squared (m²), is the simplest measure for diagnosing obesity. Obesity is linked to cardiovascular diseases, including CAE, type 2 diabetes, hypertension, and certain cancers, with higher BMI increasing the risk of disease. This study aimed to assess the BMI in patients with CAE and to investigate its potential association with the presence of the disease.Methods: In our clinic, CAE patients diagnosed via coronary angiography were retrospectively evaluated, and their BMI values were compared. BMI was calculated using height and weight records from the hospital’s automation system. The study included 111 patients and 111 control individuals.Results: A total of 222 patients were enrolled in the study. It was observed that BMI values were significantly higher in individuals diagnosed with CAE compared to the control group. Moreover, several clinical parameters, including advanced age, diabetes mellitus, hypertension, smoking, and elevated low-density lipoprotein cholesterol (LDL) levels, were associated with the presence of CAE. Conclusion: In this study, BMI was significantly higher in CAE patients. Obesity may contribute to CAE through metabolic factors. Further research is needed to clarify the mechanisms and assess the benefits of weight control in CAE prevention. KW - Body-mass index (BMI) KW - coronary artery ectasia (CAE) KW - comorbid diseases N2 - Aims: Coronary artery ectasia (CAE) is defined as the dilation of a coronary artery to at least 1.5 times the diameter of the adjacent normal segment, detected in 0.3%-5.3% of coronary angiographies. The body-mass index (BMI), calculated as weight (kg) divided by height squared (m²), is the simplest measure for diagnosing obesity. Obesity is linked to cardiovascular diseases, including CAE, type 2 diabetes, hypertension, and certain cancers, with higher BMI increasing the risk of disease. This study aimed to assess the BMI in patients with CAE and to investigate its potential association with the presence of the disease.Methods: In our clinic, CAE patients diagnosed via coronary angiography were retrospectively evaluated, and their BMI values were compared. BMI was calculated using height and weight records from the hospital’s automation system. The study included 111 patients and 111 control individuals.Results: A total of 222 patients were enrolled in the study. It was observed that BMI values were significantly higher in individuals diagnosed with CAE compared to the control group. Moreover, several clinical parameters, including advanced age, diabetes mellitus, hypertension, smoking, and elevated low-density lipoprotein cholesterol (LDL) levels, were associated with the presence of CAE. Conclusion: In this study, BMI was significantly higher in CAE patients. Obesity may contribute to CAE through metabolic factors. Further research is needed to clarify the mechanisms and assess the benefits of weight control in CAE prevention. CR - Ovalı C, Morrad B. Associations between coronary artery disease, aneurysm and ectasia. Kardiochir Torakochirurgia Pol. 2017;14(3):158-163. doi:10.5114/kitp.2017.70276 CR - Yılmaz M, Nail Bilen M. (2018). An angiographic curiosity: coronary artery ectasia. A review of possible aetiological factors, clinical and histopathological features and treatment. Cardiovasc Disorders Med. 2018;3(4):1-6. CR - Ahmad M, Mungee S. Coronary ectasia. In StatPearls [Internet]. StatPearls Publishing. 2022. CR - Roh JW, Park EH, Song JC, et al. ST-segment elevation myocardial infarction as a result of coronary artery ectasia-related intracoronary thrombus in a patient with liver cirrhosis. Korean J Crit Care Med. 2015; 30(4):358-364. doi:10.4266/kjccm.2015.30.4.358 CR - Pekkoç Uyanık KÇ, Kılıçarslan O, Ser Ö, Öztürk O, Yılmaz Aydoğan H. Koroner arter ektazi ve genetik yatkınlık. Halic Uni J Health Sci. 2020; 3(1):27-32. CR - Hansson GK, Hermansson A. The immune system in atherosclerosis. Nature Immunology. 2011;12(3):204-212. doi:10.1038/ni.2001 CR - Baysal SS, Koç Ş, Özbek K, Bayhatun M. Elevated oxidative stress markers as independent predictors of isolated coronary artery ectasia. Postepy Kardiol Interwencyjnej. 2025;21(1):67-72. doi:10.5114/aic.2025.148148 CR - World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. Geneva: World Health Organization; 2000. (WHO Technical Report Series, No. 894). CR - BMI chart with obesity classifications adopted from the WHO 1998 report. Contributed by the World Health Organization-"Report of a WHO consultation on obesity. Obesity Preventing and Managing a Global Epidemic."Obesity Surgery Indications and Contraindications, Treasure Island (FL): StatPearls Publishing; 2025. CR - Khan SS, Ning H, Wilkins JT, et al. Association of body-mass index with lifetime risk of cardiovascular disease and compression of morbidity. JAMA Cardiol. 2018;3(4):280-287. doi:10.1001/jamacardio. 2018.0022 CR - Neeland IJ, Ross R, Després JP, et al. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol. 2019;7(9):715-725. doi:10.1016/S2213-8587 (19)30084-1 CR - Stefan N, Schick F, Häring HU. Causes, characteristics, and consequences of metabolically unhealthy normal weight in humans. Cell Metabolism. 2017;26(2):292-300. doi:10.1016/j.cmet.2017.07.008 CR - Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006;113(6):898-918. doi:10.1161/CIRCULATIONAHA.106.171016 CR - Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113(15):1888-1904. doi:10.1161/CIRCULATIONAHA.105.563213 CR - Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol. 2009; 53(21):1925-1932. doi:10.1016/j.jacc.2008.12.068 CR - Donmez E, Ozcan S. The relationship between obesity and coronary artery ectasia in patients presenting with acute coronary syndromes. Ann Med Res. 2023;30(2):161-166. CR - Libby P, Ridker PM, Hansson GK; Leducq Transatlantic Network on Atherothrombosis. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009;54(23):2129-2138. doi:10.1016/j.jacc.2009.09.009 CR - Lavie CJ, Laddu D, Arena R, Ortega FB, Alpert MA, Kushner RF. Healthy weight and obesity prevention: JACC health promotion series. J Am Coll Cardiol. 2018;72(13):1506-1531. doi:10.1016/j.jacc.2018.08.1037 CR - Richards GHC, Hong KL, Henein MY, Hanratty C, Boles U. Coronary artery ectasia: review of the non-atherosclerotic molecular and pathophysiologic concepts. Int J Mol Sci. 2022;23(9):5195. doi:10.3390/ijms23095195 CR - Jiang L, Wei W, Kang S, Li XL, Luo Y. Insights into lipid metabolism and immune-inflammatory responses in the pathogenesis of coronary artery ectasia. Front Physiol. 2023;14:1096991. doi:10.3389/fphys.2023.1096991 CR - Kwaifa IK, Bahari H, Yong YK, Noor SM. Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications. Biomolecules. 2020;10(2):291. doi:10.3390/biom10020291 CR - Iacobellis G. Epicardial adipose tissue in contemporary cardiology. Nat Rev Cardiol. 2022;19(9):593-606. doi:10.1038/s41569-022-00679-9 CR - Cai Z, Li L, Wang H, et al. Effect of type 2 diabetes on coronary artery ectasia: smaller lesion diameter and shorter lesion length but similar adverse cardiovascular events. Cardiovasc Diabetol. 2022;21(1):9. doi:10. 1186/s12933-022-01444-5 CR - Mu J, Weng Y, Xiao J, et al. Association of remnant cholesterol with coronary artery ectasia: a cross-sectional study. Lipids Health Dis. 2024; 23(1):240. doi:10.1186/s12944-024-02225-7 CR - Qin Y, Tang C, Ma C, Yan G. Risk factors for coronary artery ectasia and the relationship between hyperlipidemia and coronary artery ectasia. Coron Artery Dis. 2019;30(3):211-215. doi:10.1097/MCA.0000000000000709 CR - Humphrey JD. Mechanisms of vascular remodeling in hypertension. Am J Hypertens. 2021;34(5):432-441. doi:10.1093/ajh/hpaa195 CR - Xi Z, Qiu H, Guo T, et al. Prevalence, predictors, and impact of coronary artery ectasia in patients with atherosclerotic heart disease. Angiology. 2023;74(1):47-54. doi:10.1177/00033197221091644 CR - Rojas-Milán E, León CEM, García-Rincón A, et al. Cardiovascular risk factors associated with coronary ectasia and acute myocardial infarction. Factores de riesgo cardiovascular asociados a ectasia coronaria e infarto agudo de miocardio. Gac Med Mex. 2021;157(6):604-609. doi:10.24875/GMM.M21000624 CR - Selthofer-Relatić K, Bošnjak I, Kibel A. Obesity Related coronary microvascular dysfunction: from basic to clinical practice. Cardiol Res Pract. 2016;2016:8173816. doi:10.1155/2016/8173816 UR - https://doi.org/10.38053/acmj.1692331 L1 - https://dergipark.org.tr/tr/download/article-file/4840212 ER -