TY  - JOUR
T1  - Effect of Thymoquinone and Butylated Hydroxytoluene on Behavior and Oxidative Stress Level in Rats Chronically Exposed to Ethanol
TT  - Effect of Thymoquinone and Butylated Hydroxytoluene on Behavior and Oxidative Stress Level in Rats Chronically Exposed to Ethanol
AU  - Kuzay Aksoy, Dilek
PY  - 2025
DA  - July
Y2  - 2025
DO  - 10.19127/bshealthscience.1700003
JF  - Black Sea Journal of Health Science
JO  - BSJ Health Sci.
PB  - Karyay Karadeniz Yayımcılık Ve Organizasyon Ticaret Limited Şirketi
WT  - DergiPark
SN  - 2619-9041
SP  - 156
EP  - 164
VL  - 8
IS  - 4
LA  - en
AB  - The objective of this study is to examine the antioxidant activity of Thymoquınone (TQ) and Butylated Hydroxytoluene (BHT) and its effect on behavioral tests in rats chronically exposed to ethanol. The experimental groups were determined as Control, Sham, Ethanol, Ethanol+BHT, Ethanol+TQ and Ethanol+BHT+TQ. In order to create a chronic alcohol exposure model in rats, 7 g/kg ethanol was given for 4 weeks. BHT and TQ were given at a dose of 10 mg/kg for 4 weeks. Glutathione, malondylaldehyde and total nitric oxide levels were analyzed to evaluate oxidative stress in brain, stomach, liver and kidney tissue. Open field test and forced swim test were used to examine anxiety disorder and depression-like behaviors in rats. Compared with the control group, ethanol exposure increased malondylaldehyde and total nitric oxide levels and decreased glutathione levels in all tissues (P
KW  - Ethanol
KW  - Behavior
KW  - Oxidative Stress
KW  - Antioxidants
KW  - Rats
KW  - Nigella sativa
N2  - The objective of this study is to examine the antioxidant activity of Thymoquınone (TQ) and Butylated Hydroxytoluene (BHT) and its effect on behavioral tests in rats chronically exposed to ethanol. The experimental groups were determined as Control, Sham, Ethanol, Ethanol+BHT, Ethanol+TQ and Ethanol+BHT+TQ. In order to create a chronic alcohol exposure model in rats, 7 g/kg ethanol was given for 4 weeks. BHT and TQ were given at a dose of 10 mg/kg for 4 weeks. Glutathione, malondylaldehyde and total nitric oxide levels were analyzed to evaluate oxidative stress in brain, stomach, liver and kidney tissue. Open field test and forced swim test were used to examine anxiety disorder and depression-like behaviors in rats. Compared with the control group, ethanol exposure increased malondylaldehyde and total nitric oxide levels and decreased glutathione levels in all tissues (P
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UR  - https://doi.org/10.19127/bshealthscience.1700003
L1  - https://dergipark.org.tr/tr/download/article-file/4873345
ER  -