@article{article_1701122, title={Global trends and scientific networks in mesenchymal stem cell research in hematology: a 20-year bibliometric insight}, journal={Journal of Medicine and Palliative Care}, volume={6}, pages={290–297}, year={2025}, DOI={10.47582/jompac.1701122}, author={Mandacı Şanlı, Neslihan and Mandacı, Edanur Dilara}, keywords={Mezenkimal kök hücreler, hematoloji, bibliyometrik analiz, bilimsel iş birliği, bilimsel ağ haritalama}, abstract={Aims: Mesenchymal stem cells (MSCs) are multipotent stromal cells that are differentiated due to their differentiation potential and immunomodulatory activities, which is highly relevant to regenerative medicine and hematological therapies. MSCs remain one of the most actively pursued research areas in bioengineering, however, their bibliometric structure in the context of hematology is MSCs has not been thoroughly investigated. In this particular case, we set out to assess MSCs in the field of hematology by evaluating scientific output, its thematic evolution, as well as patterns of global collaboration using bibliometric techniques.
Methods: With the keyword “MSCs” in the title and restricted to the “hematology” category, a total of 1.656 publications from the years 2005 to 2024 were retrieved using Web of Science Core Collection. The data was analyzed using VOSviewer (v1.6.11) and SPSS (v25.0). Trends in annual publication activities, journal output per publication, citation rates of the most cited works, co authored keyword networks, institutional and author cooperation networks, and and citation activity by country was examined. Results: As noted, there was a significant increase in the publication rate from 2011-2015, followed by a decrease after this period. Over 65% of publications were contributed by two journals–Stem Cells and Development and Stem Cells. Studies that received the most citations concentrated on the immunomodulatory mechanisms of MSCs and the specific properties of tissues. University of Genoa claimed the highest citation count per article, whereas Chinese higher education institutions published the most on the topic. Core themes such as ‘differentiation,’ ‘bone marrow,’ ‘transplantation,’ and ‘exosomes’ emerged from the analysis on keyword clustering. The most noteworthy research backbone on the topic was developed collaboratively between the US and China, who both possessed strong global network intercontinental links.
Conclusion: Research on MSCs in the context of hematology showcases mature thematic development, intensive institutional collaboration, and regional collaboration clustering. The area of MSCs in hematology indicates foundational research exhaustion, but an expanding focus on exosomes and therapies that do not involve cells signals prospective, shift aimed at clinical. The work can strategically direct funding, policy, and interdisciplinary collaboration MSCs in policymaking guidance MSCs in hematology applications mean interdisciplinary MSCs guide policy.}, number={4}, publisher={MediHealth Academy Yayıncılık}, organization={This research received no financial support from any funding agency, commercial or not-for-profit sectors.}