TY  - JOUR
T1  - Thymus pectinatus var. pectinatus Uçucu Yağı ve Ekstresinin Anti-aging Potansiyelinin Kollajenaz ve Tirozinaz Enzim İnhibisyonu Üzerinden Değerlendirilmesi
TT  - Evaluation of Anti-aging Potential of Thymus pectinatus var. pectinatus Essential Oil and Extract via Collagenase and Tyrosinase Enzyme Inhibition
AU  - Sönmez Gürer, Eda
AU  - Koçak, Şeyma
AU  - Baydar, Rengin
AU  - Karadağ, Ayşe Esra
AU  - Altıntaş, Ayhan
PY  - 2025
DA  - June
Y2  - 2025
DO  - 10.62425/crihs.1702484
JF  - Current Research in Health Sciences
JO  - Curr Res Health Sci
PB  - Atatürk Üniversitesi
WT  - DergiPark
SN  - 3023-6991
SP  - 55
EP  - 60
VL  - 2
IS  - 2
LA  - tr
AB  - Amaç: Bu çalışmada, Thymus pectinatus var. pectinatus türünden elde edilen uçucu yağ ve etanolik ekstraktın kollajenaz ve tirozinaz enzimleri üzerindeki inhibitör etkilerini belirleyerek, bu türün anti-aging ve leke karşıtı kozmetik uygulamalardaki potansiyelini değerlendirmek amaçlanmıştır.Yöntemler: Toprak üstü kısımlara ait kuru bitki örneğinden Clevenger tipi distilasyon düzeneği ile uçucu yağ elde edilmiştir. Kuru örnek öğütülerek etanol ile ekstre edilmiş ve çözücü buharlaştırılmıştır. Elde edilen ekstreler üzerinde anti-kollajenaz ve anti-tirozinaz aktivite çalışmaları yapılmıştır.Bulgular: Uçucu yağın etanol ekstresine kıyasla daha yüksek anti-kollajenaz (%52.3 ± 0.12 inhibisyon) ve anti-tirozinaz (%73.5 ± 0.23 inhibisyon) aktivitelerine sahip olduğu belirlendi.Sonuç: Uçucu yağ ve etanolik ekstraktın kollajenaz ve tirozinaz enzimleri üzerinde belirli düzeyde inhibitör aktivite sergilediğini ortaya koymuştur. Ancak karşılaştırmalı analizler sonucunda, uçucu yağın etanol ekstresine kıyasla her iki enzim üzerinde de daha güçlü bir inhibisyon etkisi gösterdiği belirlenmiştir. Bu sonuçlar; özellikle yaşlanma karşıtı ve cilt yenileyici kozmetik formülasyonlarda kekik uçucu yağının hem tek başına hem de diğer anti-kollajenaz ajanlarla birlikte kullanılabilecek etkili bir bileşen olabileceğini göstermektedir.
KW  - kekik
KW  - kollajenaz enzimi
KW  - tirozinaz enzimi
KW  - thymus pectinatus var pectinatus
N2  - Objective: This study aimed to determine the inhibitory effects of the essential oil and ethanolic extract obtained from Thymus pectinatus var. pectinatus species on collagenase and tyrosinase enzymes and to evaluate the potential of this species in anti-aging and anti-blemish cosmetic applications.Methods: Essential oil was obtained from the dry plant sample of the aboveground parts with a Clevenger type distillation apparatus. The dry sample was ground and extracted with ethanol and the solvent was evaporated. Anti-collagenase and anti-tyrosinase activity studies were performed on the obtained extracts.Results: It was determined that the essential oil had higher anti-collagenase (52.3 ± 0.12% inhibition) and anti-tyrosinase (73.5 ± 0.23% inhibition) activities compared to the ethanol extract.Conclusion: It was revealed that the essential oil and ethanolic extract exhibited a certain level of inhibitory activity on collagenase and tyrosinase enzymes. However, as a result of comparative analyses, it was determined that the essential oil showed a stronger inhibitory effect on both enzymes compared to the ethanol extract. These results indicate that thyme essential oil can be an effective ingredient that can be used both alone and in combination with other anti-collagenase agents, especially in anti-aging and skin rejuvenating cosmetic formulations.
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UR  - https://doi.org/10.62425/crihs.1702484
L1  - https://dergipark.org.tr/tr/download/article-file/4884316
ER  -