TY  - JOUR
T1  - Evaluation of biomaterial containing alginate and egg-shell membrane incorporated with β-tricalcium phosphate for treatment of bone defects
TT  - Kemik defektlerinin tedavisi için β-trikalsiyum fosfat ile birleştirilmiş aljinat ve yumurta kabuğu zarı içeren biyomateryalin değerlendirilmesi
AU  - Unal, Semra
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.7240/jeps.1703374
JF  - International Journal of Advances in Engineering and Pure Sciences
JO  - JEPS
PB  - Marmara Üniversitesi
WT  - DergiPark
SN  - 2636-8277
SP  - 293
EP  - 298
VL  - 37
IS  - 3
LA  - en
AB  - The freeze-drying procedure was used to create the scaffold that was meant to cure bone deformities. Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction analysis, swelling and degradation ratio, and scanning electron microscopy (SEM) tests were used to characterize the scaffolds. Osteoblast cells were used in an in vitro cytotoxicity test to evaluate the scaffolds' biocompatibility. The results of the characterization revealed an interconnected porous structure and significant ionic connections between the alginate, egg-shell membrane, and β-tricalcium phosphate (β-TCP). The scaffolds are regarded as nontoxic because the cell viability was more than 80%. When all the findings are evaluated, β-TCP with alginate/egg-shell membrane can be regarded as appropriate for bone treatment applications.
KW  - alginate
KW  - egg shell membrane
KW  - beta-tricalcium phosphate
KW  - tissue engineering
N2  - Kemik defektlerinin tedavisi için tasarlanan iskele, dondurarak kurutma yöntemi kullanılarak üretilmiştir. İskelelerin karakterizasyonu fourier transform infrared (FTIR) spektroskopisi ve X-ışını kırınım analizi, şişme ve bozunma oranı, taramalı elektron mikroskobu (SEM) testleri kullanılarak gerçekleştirilmiştir. İskelelerin biyouyumluluğunu analiz etmek için osteoblast hücreleri ile in vitro sitotoksisite deneyi yapılmıştır. Karakterizasyon sonuçları aljinat, yumurta kabuğu membranı ve β-TCP arasında güçlü iyonik etkileşimler ve birbirine bağlı gözenekli yapı olduğunu göstermiştir. Hücre canlılığının %80'den fazla olması iskelelerin toksik olmadığını göstermektedir. Tüm sonuçlar birlikte değerlendirildiğinde, aljinat/yumurta kabuğu zarı içeren β-TCP'nin kemik tedavisi uygulamaları için uygun olduğu düşünülebilir.
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UR  - https://doi.org/10.7240/jeps.1703374
L1  - https://dergipark.org.tr/tr/download/article-file/4888447
ER  -