TY  - JOUR
T1  - Sinerjik Bir Bitkisel Formülasyonun Antioksidan, Antienflamatuar ve Yaşlanma Karşıtı Etkileri
TT  - Antioxidant, Anti-inflammatory, and Anti-aging Effects of a Synergistic Herbal Formulation
AU  - Karayel, Hasan Basri
AU  - Karaman, Serhat
AU  - Budak, Yakup
PY  - 2025
DA  - August
Y2  - 2025
JF  - Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi
PB  - Erciyes Üniversitesi
WT  - DergiPark
SN  - 1012-2354
SP  - 535
EP  - 547
VL  - 41
IS  - 2
LA  - tr
AB  - Öz: Bu çalışmada Achillea millefolium, Symphytum officinale ve Matricaria chamomilla'nın etanolik ekstrelerinden hazırlanan sinerjik bir fitokompleksin dermatolojik etkileri araştırılmıştır. Biyoaktif bileşenler analiz edilmiş ve formüle edilen serumun antioksidan, anti-enflamatuar ve yaşlanma karşıtı (kolajenaz, elastaz inhibisyonu) potansiyeli değerlendirilmiştir. Fizikokimyasal stabilite, yapısal karakterizasyon (FTIR) ve in vitro salım çalışmaları gerçekleştirilmiştir. Çok fonksiyonlu serum (MFS) insan dermal fibroblast (HDF) ve keratinosit (HaCaT) hücrelerinde sitotoksik etki göstermemiştir. Üçlü kombinasyon, tekli ekstraktlardan daha üstün aktivite sergilemiştir ve cilt sağlığı için güvenli ve cazip bir aday olabilir.
KW  - Antioksidan Aktivite
KW  - Cilt Sağlığı
KW  - Achillea millefolium
KW  - Symphytum officinale
KW  - Matricaria chamomilla.
N2  - Abstract: This study investigated the dermatological effects of a synergistic phytocomplex prepared from ethanolic extracts of Achillea millefolium, Symphytum officinale, and Matricaria chamomilla. Bioactive components were analyzed, and the formulated serum's antioxidant, anti-inflammatory, and anti-aging (collagenase, elastase inhibition) potential was evaluated. Physicochemical stability, structural characterization (FTIR), and in vitro release studies were performed. Multifunctional serum (MFS) showed no cytotoxic effect in human dermal fibroblast (HDF) and keratinocyte (HaCaT) cells. The triple combination exhibited superior activity to single extracts and may be a safe and compelling candidate for skin health.
CR  - C. Parrado, S. Mercado-Saenz, A. Perez-Davo, Y. Gilaberte, S. Gonzalez, A. Juarranz, Front. Pharmacol. 2019, 10, 759.
CR  - T. Aburjai, F. M. Natsheh, Phytother. Res. 2003, 17, 987.
CR  - M. Działo, J. Mierziak, U. Korzun, M. Preisner, J. Szopa, A. Kulma, Int. J. Mol. Sci. 2016, 17, 160.
CR  - B. Ali, N. A. Al-Wabel, S. Shams, A. Ahmad, S. A. Khan, F. Anwar, Asian Pac. J. Trop. Biomed. 2015, 5, 601.
CR  - C. Staiger, Phytother. Res. 2012, 26, 1441.
CR  - J. K. Srivastava, E. Shankar, S. Gupta, Mol. Med. Rep. 2010, 3, 895.
CR  - S. L. McMillin, D. L. Schmidt, B. B. Kahn, C. A. Witczak, Diabetes 2017, 66, 1491.
CR  - L. Yuan, P. Liang, Y. Qu, T. An, J. Wang, X. Deng, L. Bai, P. Shen, D. Bai, Food Chem. Toxicol. 2020, 145, 111736.
CR  - D. L. McKay, J. B. Blumberg, Phytother. Res. 2006, 20, 519.
CR  - V. L. Singleton, R. Orthofer, R. M. Lamuela-Raventós, Methods Enzymol. 1999, 299, 152.
CR  - J. Zhishen, T. Mengcheng, W. Jianming, Food Chem. 1999, 64, 555.
CR  - N. Sánchez-Marzo, J. Lozano-Sánchez, M. L. Cádiz-Gurrea, M. Herranz-López, V. Micol, A. Segura-Carretero, Microchem. J. 2024, 194, 109135.
CR  - A. Cano, A. B. Maestre, J. Hernández-Ruiz, M. B. Arnao, Processes 2023, 11, 185.
CR  - X. Huang, Y. Li, B. Sabier, J. Yes, P. Wang, Y. Sen, X. Zhang, J. Liu, eFood 2024, 5, e160.
CR  - M. Lončarić, I. Strelec, T. Moslavac, D. Šubarić, V. Pavić, M. Molnar, Biomolecules 2021, 11, 152.
CR  - H. E. Van Wart, D. R. Steinbrink, Anal. Biochem. 1981, 113, 356.
CR  - E. G. de Jesus, F. F. de Souza, J. V. Andrade, M. L. Andrade E Silva, W. R. Cunha, R. C. Ramos, O. S. Campos, J. A. N. Santos, M. F. C. Santos, Nat. Prod. Res. 2024, 38, 879.
CR  - M. Ghasemi, S. Liang, Q. M. Luu, I. Kempson, Methods Mol. Biol. 2023, 2644, 15.
CR  - E. M. Williamson, Phytomedicine 2001, 8, 401.
CR  - D. Egamberdieva, N. Mamedov, E. Ovidi, A. Tiezzi, L. Craker, J. Med. Active Plants 2017, 5, 59.
CR  - K. D. P. P. Gunathilake, K. K. D. S. Ranaweera, H. P. V. Rupasinghe, Biomedicines 2018, 6, 107.
CR  - J. K. Srivastava, S. Gupta, Mol. Cell. Pharmacol. 2009, 1(3), 138.
CR  - J. Siepmann, N. A. Peppas, Adv. Drug Deliv. Rev. 2001, 48, 139.
CR  - A. Munin, F. Edwards-Lévy, Pharmaceutics 2011, 3, 793.
CR  - R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, C. Rice-Evans, Free Radic. Biol. Med. 1999, 26, 1231.
CR  - M. S. Blois, Nature 1958, 181, 1199.
CR  - S. Saeidnia, A. Gohari, N. Mokhber-Dezfuli, F. Kiuchi, Daru 2011, 19, 173.
CR  - I. Süntar, E. K. Akkol, H. Keleş, A. Oktem, K. H. Başer, E. Yeşilada, J. Ethnopharmacol. 2011, 134, 627.
CR  - S. Benedek, N. Popescu, D. Oniga, R. Oprean, M. Tămaş, J. Planar Chromatogr. 2007, 20, 117.
CR  - B. Benedek, B. Kopp, M. F. Melzig, J. Ethnopharmacol. 2007, 113, 312.
CR  - B. Benedek, N. Geisz, W. Jäger, T. Thalhammer, B. Kopp, Pharmazie 2006, 61, 1052.
CR  - S. Kültür, J. Ethnopharmacol. 2007, 111, 341.
CR  - T. Juríková, S. Skrovankova, D. Mlcek, S. Balla, L. Snopek, Molecules 2019, 24, 1.
CR  - M. Neagu, G. Paun, C. Albu, G. L. Radu, J. Serb. Chem. Soc. 2011, 76, 965.
CR  - A. Chevallier, Encyclopedia of Herbal Medicine, 3rd ed., DK Publishing, New York, 2016.
CR  - M. Wichtl, Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis, 3rd ed., Medpharm Scientific Publishers, Stuttgart, 2004.
CR  - M. Blumenthal, A. Goldberg, J. Brinckmann, Herbal Medicine: Expanded Commission E Monographs, Integrative Medicine Communications, Newton, 2000.
CR  - V. Srivastava, A. Darokar, K. Fatima, J. Darokar, Pharmacogn. Rev. 2018, 12, 52.
CR  - J. Gruenwald, T. Brendler, C. Jaenicke, PDR for Herbal Medicines, 4th ed., Thomson Healthcare, Montvale, 2007.
CR  - S. Burt, Int. J. Food Microbiol. 2004, 94, 223.
CR  - F. Bakkali, S. Averbeck, D. Averbeck, M. Idaomar, Food Chem. Toxicol. 2008, 46, 446.
CR  - M. Valko, D. Leibfritz, J. Moncol, M. T. Cronin, M. Mazur, J. Telser, Int. J. Biochem. Cell Biol. 2007, 39, 44.
CR  - H. Y. Aboul-Enein, L. I. Kruk, A. Kladna, K. Lichszteld, T. Michalska, Biopolymers 2007, 86, 222.
CR  - Y. Cai, Q. Luo, M. Sun, H. Corke, Life Sci. 2004, 74, 2157.
CR  - C. A. Rice-Evans, N. J. Miller, G. Paganga, Free Radic. Biol. Med. 1996, 20, 933.
CR  - D. Huang, B. Ou, R. L. Prior, J. Agric. Food Chem. 2005, 53, 1841.
CR  - W. Brand-Williams, M. E. Cuvelier, C. Berset, LWT - Food Sci. Technol. 1995, 28, 25.
UR  - https://dergipark.org.tr/tr/pub/erciyesfen/issue//1707715
L1  - https://dergipark.org.tr/tr/download/article-file/4908020
ER  -