@article{article_1710873, title={Prognostic Significance of Neutrophil/Lymphocyte Ratio and SOFA Score in Patients with Chronic Obstructive Pulmonary Disease Followed in Intensive Care Unit}, journal={Kocaeli Üniversitesi Sağlık Bilimleri Dergisi}, volume={11}, pages={138–142}, year={2025}, DOI={10.30934/kusbed.1710873}, author={Ceran, Güzin and Çamur, Oğuzhan and Ceyhan, Ecenur and Karadağ, Sultan and Özel, Muhammet Köksal and Tuncer, Mustafa Enes and Turgut, Dileksu and Polat, Deniz Sude and Gökmen, Kezban Melike and Bulut, Melisa and et al.}, keywords={KOAH, SOFA( The Sepsis Organ Failure Assessment) skoru, Nötrofil/Lenfosit oranı(NLR), YBÜ, ölüm}, abstract={Objective: Chronic Obstructive Pulmonary Disease (COPD) has become one of the leading causes of increasing morbidity and mortality worldwide. Inflammation is known to play an important role in the pathogenesis of COPD. Neutrophil-lymhocyte ratio (NLR) is an inflammatory biomarker which indicates the balance of the immune system and reflecting systemic inflammation. One of the most commonly used scoring models for predicting mortality in intensive care is the Sepsis Organ Failure Assessment (SOFA) scoring. The aim of our study is to investigate the prognostic significance of NLR and SOFA score in patients admitted to the intensive care unit (ICU) with COPD. Methods: A retrospective, single-center cohort study was conducted between 01.09.2022-01.09.2024. Patients over the age of 18 who were admitted to the intensive care unit of Kırşehir Training and Research Hospital with a diagnosis of COPD. Data of age, gender, comorbidities, SOFA score, NLR, number of invasive and non-invasive mechanical ventilation days, length of hospital stay, length of ICU stay, and 30-day mortality. Logistic regression analysis was used to predict mortality. Results: Data from 259 patients were evaluated. The mean age of the patients was 72 (14). Sixty-seven patients died and 192 patients were discharged. β coefficient for the NLR was 0.014419 (p=0.0383). β coefficient for the SOFA score was 0.382920 (p <0.001). From the ROC (Receiver Operating Characteristic) curve, it appears that the model has a high AUC (Area Under Curve), which indicates that the model is quite good at distinguishing classes. SOFA score and NLR were found to be higher in deceased patients. Conlusion: In ICU follow-up, SOFA score and NLR can be examined together to early detect critically COPD patients and predict mortality.}, number={3}, publisher={Kocaeli Üniversitesi}