TY - JOUR T1 - Prognostic Significance of Neutrophil/Lymphocyte Ratio and SOFA Score in Patients with Chronic Obstructive Pulmonary Disease Followed in Intensive Care Unit TT - Yoğun Bakım Ünitesinde Kronik Obstrüktif Akciğer Hastalığı Tanısıyla Takip Edilen Hastalarda Nötrofil /Lenfosit Oranı ve SOFA Skorunun Prognostik Önemi AU - Ceran, Güzin AU - Çamur, Oğuzhan AU - Ceyhan, Ecenur AU - Karadağ, Sultan AU - Özel, Muhammet Köksal AU - Tuncer, Mustafa Enes AU - Turgut, Dileksu AU - Polat, Deniz Sude AU - Gökmen, Kezban Melike AU - Bulut, Melisa AU - Küçük, Elif Ebrar AU - Yaman, Gaye AU - Karpuz, Şehide Selene AU - Özdemir, Hilal PY - 2025 DA - September Y2 - 2025 DO - 10.30934/kusbed.1710873 JF - Kocaeli Üniversitesi Sağlık Bilimleri Dergisi JO - KOU Sag Bil Derg PB - Kocaeli Üniversitesi WT - DergiPark SN - 2149-8571 SP - 138 EP - 142 VL - 11 IS - 3 LA - en AB - Objective: Chronic Obstructive Pulmonary Disease (COPD) has become one of the leading causes of increasing morbidity and mortality worldwide. Inflammation is known to play an important role in the pathogenesis of COPD. Neutrophil-lymhocyte ratio (NLR) is an inflammatory biomarker which indicates the balance of the immune system and reflecting systemic inflammation. One of the most commonly used scoring models for predicting mortality in intensive care is the Sepsis Organ Failure Assessment (SOFA) scoring.The aim of our study is to investigate the prognostic significance of NLR and SOFA score in patients admitted to the intensive care unit (ICU) with COPD.Methods: A retrospective, single-center cohort study was conducted between 01.09.2022-01.09.2024. Patients over the age of 18 who were admitted to the intensive care unit of Kırşehir Training and Research Hospital with a diagnosis of COPD. Data of age, gender, comorbidities, SOFA score, NLR, number of invasive and non-invasive mechanical ventilation days, length of hospital stay, length of ICU stay, and 30-day mortality. Logistic regression analysis was used to predict mortality.Results: Data from 259 patients were evaluated. The mean age of the patients was 72 (14). Sixty-seven patients died and 192 patients were discharged. β coefficient for the NLR was 0.014419 (p=0.0383). β coefficient for the SOFA score was 0.382920 (p KW - COPD KW - SOFA( The Sepsis Organ Failure Assessment) score KW - Neutrophil-lymhocyte ratio(NLR) KW - ICU KW - mortality N2 - AmaçKronik Obstrüktif Akciğer Hastalığı(KOAH), dünya çapında artan morbidite ve mortalitenin önde gelen nedenlerinden biri haline gelmiştir. İnflamasyonun KOAH patogenezinde önemli bir rol oynadığı bilinmektedir. Nötrofil-lenfosit oranı (NLR), bağışıklık sisteminin dengesini gösteren ve sistemik inflamasyonu yansıtan bir inflamatuar biyobelirteçtir. Yoğun bakımda mortalite tahmininde en çok kullanılan skorlama modellerinden biri Sepsis Organ Yetmezliği Değerlendirme (SOFA) skorlamasıdır.Çalışmamızın amacı, KOAH nedeniyle yoğun bakıma yatırılan hastalarda NLR ve SOFA skorunun prognostik önemini araştırmaktır.Yöntem01.09.2022-01.09.2024 tarihleri arasındaKOAH nedeni ile yoğun bakım unitesine yatırılan 18 yaş üstü hastalar retrospektif olarak incelendi. Yaş, cinsiyet, eşlik eden hastalıklar, SOFA skoru, NLR, invaziv ve noninvaziv mekanik ventilasyon gün sayısı, hastanede kalış süresi, yoğun bakımda kalış süresi ve 30 günlük mortalite verileri incelendi.Bulgular259 hastadan alınan veriler değerlendirildi. Hastaların ortalama yaşı 72 idi(14). 67 hasta ex oldu, 192 hasta taburcu edildi. NLR için β katsayısı 0,014419 idi (p = 0,0383). SOFA skoru için β katsayısı 0,382920 idi (p < 0,001). ROC Eğrisinden, modelin yüksek bir AUC'ye sahip olduğu görünmektedir bu da modelin sınıfları ayırt etmede oldukça iyi olduğunu gösterir. Ölen hastalarda SOFA skoru ve NLR'nin daha yüksek olduğu bulundu.SonuçYoğun bakım takibinde, kritik KOAH hastalarının erken teşhisi ve mortalitenin öngörülmesi için SOFA skoru ve NLR birlikte incelenebilir. CR - Xiao K, Guo C, Su L, Yan P, Li X, Xie L. Prognostic value of different scoring models in patients with multiple organ dysfunction syndrome associated with acute COPD exacerbation. Journal of thoracic disease. 2015;7(3):329. CR - Akhter S, Warraich UA, Ghazal S, Rizvi N. Assessment and comparison of APACHE II (acute physiology and chronic health evaluation), SOFA (sequential organ failure assessment) score and curb 65 (confusion; urea; respiratory rate; blood pressure), for prediction of inpatient mortality in acute exacerbation of chronic obstructive pulmonary disease. JPMA. 2019;69(2):211-215. CR - Celli BR, Fabbri LM, Aaron SD, et al. An updated definition and severity classification of chronic obstructive pulmonary disease exacerbations: the Rome proposal. 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CR - Doganay GE, Cirik MO, Doganay GE. Are neutrophil-lymphocyte, platelet-lymphocyte, and monocyte-lymphocyte ratios prognostic indicators in patients with chronic obstructive pulmonary disease in intensive care units? Cureus. 2022;14(3) UR - https://doi.org/10.30934/kusbed.1710873 L1 - https://dergipark.org.tr/tr/download/article-file/4922259 ER -