TY  - JOUR
T1  - Lipolyse Enzyms Levels in Patients with Obstructive Sleep Apnea Syndrome; Especially Perilipin-1
TT  - Obstrüktif Uyku Apne Sendromlu Hastalarda Lipoliz Enzim Düzeyleri; Özellikle Perilipin-1
AU  - Yıldız, Saliha
AU  - Günbatar, Hülya
AU  - Kömüroğlu, Ahmet Ufuk
AU  - Sünnetçioğlu, Aysel
AU  - Alay, Murat
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.52976/vansaglik.1711771
JF  - Van Sağlık Bilimleri Dergisi
JO  - Van Sağ Bil Derg
PB  - Van Yüzüncü Yıl Üniversitesi
WT  - DergiPark
SN  - 2667-5072
SP  - 123
EP  - 130
VL  - 18
IS  - 2
LA  - en
AB  - Introduction: Since obesity is an important risk factor in obstructive sleep apnea syndrome (OSAS), it will be important to determine the relationship between intracellular and intravascular lipolysis enzymes and OSAS. In this study we investigated the levels of lipolysis enzymes Perilipin-1 (Plin-1), adipose triglyceride lipase (ATGL), hormon sensitive lipase (HSL) and lipoprotein lipase (LPL) in patients with OSAS and the relationship between these enzymes and OSAS.Material method: 51 OSAS patients with obstructive sleep apnea syndrome and 25 volunteers diagnosed with simple snoring as a control group were included in the study. Polysomnographic evaluation, age, gender, and body mass index of each participant were recorded. Blood was taken from the participants on the same day to analyze enzymes.Results: Between the OSAS group (n:51) and the control group (n:25), age (mean: 45.3±10 vs 40.9±9.1, p value: 0.065), gender (female/male in the patient and control group, respectively: 5/46, 3/22, p value: 0.76) and BMI (min-max 23.3-40.1 vs 24-44.1, p value: 0.21, respectively) were similar. For ATGL, HSL, LPL, no significant difference was detected between the groups (median values: 65.9 vs 68.3, 7.30 vs 7.33, 484.2 vs 485.3, p values: 0.33, 0.69, 0.33, respectively). Plin-1 level was found to be significantly higher in the OSAS group (median value: 5.34 vs 4.87 ng/ml, p:0.038). It was determined that Plin-1 had a positive correlation with WASO (wake after sleep onset) and a negative correlation with total sleep time (p value: 0.003, 0.006, r value: 0.41, -0.38, respectively). In the linear regression analysis performed for the OSAS group, WASO was detected as a risk factor for Plin-1 elevation (p: 0.003, B: 0.012).Conclusion: We found that Plin-1 levels increased secondary to sleep disruptions in patients with OSAS, independent of obesity.
KW  - Obstructive Sleep Apnea Syndrome
KW  - Perilipin-1
KW  - Lipolysis
N2  - Giriş: Obstrüktif uyku apne sendromunda (OSAS) obezite önemli bir risk faktörü olduğundan, hücre içi ve damar içi lipoliz enzimleri ile OSAS arasındaki ilişkiyi belirlemek önemli olacaktır. Bu çalışmada OSAS'lı hastalarda lipoliz enzimleri Perilipin-1 (Plin-1), yağ trigliserit lipaz (ATGL), hormon duyarlı lipaz (HSL) ve lipoprotein lipaz (LPL) düzeylerini ve bu enzimler ile OSAS arasındaki ilişkiyi araştırdık.Materyal ve Yöntem: Obstrüktif uyku apne sendromu olan 51 OSAS hastası ve kontrol grubu olarak basit horlama tanısı almış 25 gönüllü çalışmaya dahil edildi. Her katılımcının polisomnografik değerlendirmesi, yaşı, cinsiyeti ve vücut kitle indeksi kaydedildi. Enzimleri analiz etmek için katılımcılardan aynı gün kan alındı. Bulgular: OSAS grubu (n:51) ile kontrol grubu (n:25) arasında yaş (ortalama: 45,3±10 vs 40,9±9,1, p değeri: 0,065), cinsiyet (hasta ve kontrol grubunda kadın/erkek, sırasıyla: 5/46, 3/22, p değeri: 0,76) ve VKİ (sırasıyla min-maks 23,3-40,1 vs 24-44,1, p değeri: 0,21) benzerdi. ATGL, HSL, LPL için gruplar arasında anlamlı fark saptanmadı (sırasıyla medyan değerler: 65,9 vs 68,3, 7,30 vs 7,33, 484,2 vs 485,3, p değerleri: 0,33, 0,69, 0,33). Plin-1 düzeyinin OSAS grubunda anlamlı olarak daha yüksek olduğu bulundu (ortanca değer: 5,34'e karşı 4,87 ng/ml, p:0,038). Plin-1'in WASO (uyku başlangıcından sonra uyanma) ile pozitif korelasyona ve toplam uyku süresi ile negatif korelasyona sahip olduğu belirlendi (sırasıyla p değeri: 0,003, 0,006, r değeri: 0,41, -0,38). OSAS grubu için yapılan doğrusal regresyon analizinde, WASO'nun Plin-1 yükselmesi için bir risk faktörü olduğu tespit edildi (p: 0,003, B: 0,012).Tartışma: Obstrüktif Uyku Apnesi Sendromu'na sahip hastalarda Plin-1 düzeylerinin obeziteye bağlı olmaksızın uyku bozukluklarına bağlı olarak arttığını bulduk.
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UR  - https://doi.org/10.52976/vansaglik.1711771
L1  - https://dergipark.org.tr/tr/download/article-file/4925963
ER  -