@article{article_1713230, title={Investigation of the Effect of Gender on Blood Parameters in Acute Renal Failure in Patients Presenting to the Emergency Department of a Hospital}, journal={Eurasian Journal of Critical Care}, volume={7}, pages={7–12}, year={2025}, author={Demir, Bilgehan and Dolanbay, Turgut and Nogay, Süleyman and Tan, Fatih and Öngenli, Ömer Faruk}, keywords={akut böbrek yetmezliğ, oksidatif stres, testesteron, östrojen}, abstract={Aim:
Acute renal failure (ARF) is a sudden change in renal function that prevents the excretion of nitrogenous wastes and disrupts the body’s fluid and electrolyte balance. Identification of ARF risk factors and development of indicators that predict mortality are crucial to improve the success of medical care. We aim to evaluate the effect of age and gender factors in patients with ARF and to evaluate the course and frequency of the disease in female patients compared to male patients. Methods:
The data of adult patients over 18 years of age who were hospitalized with a diagnosis of ARF
between 01.02.2025-01.03.2025 in the emergency department of Malatya Training and Research Hospital were retrospectively analyzed. Blood laboratory parameters were recorded and analyzed to determine whether these data were positively or negatively associated with gender. Results:
A statistically significant difference was found between age and gender in patients with ARF (p= 0.004). Female patients with ARF were older than male patients. There was a statistically significant relationship between creatinine level and gender in patients with ARF (p=0,017). Creatinine levels were higher in male ARF patients. There was no statistically significant difference between plt, hb, htc, ALT and HALP score and gender (p values 0.384; 0.078; 0.221;0.221; 0.189; 0.174, respectively). Conclusions:
The finding in our study that ARF occurs at older ages compared to men may be explained by the interaction of biological, hormonal, clinical and sociocultural factors. The renal protective effects of estrogen are realized through protection of vascular structure, support of glomerular iltration rate (GFR) and reduction of oxidative stress. However, the decrease in estrogen levels in the postmenopassusal period may be an important factor in the more rapid deterioration of renal function. The pro-inflammatory properties of testosterone and increased oxidative stress, as well as the earlier development of hypertension, atherosclerosis and chronic kidney disease in men, may be another reason why ARF occurs at a younger age in men compared to women.We found that creatinine levels were significantly higher in male patients with ARF compared to female patients. Men are known to have more muscle mass in general compared to women and this may lead to higher creatinine levels in men.}, number={2}, publisher={Acil Tıp Uzmanları Derneği}, organization={none}