TY  - JOUR
T1  - Histopathological effects of intranasal mometasone furoate on adenoidal tissue in children undergoing adenoidectomy
TT  - Histopathological effects of intranasal mometasone furoate on adenoidal tissue in children undergoing adenoidectomy
AU  - Uğurlu, Burak Numan
AU  - Aktar Uğurlu, Gülay
AU  - Keser Şahin, Havva Hande
PY  - 2025
DA  - July
Y2  - 2025
DO  - 10.38053/acmj.1713707
JF  - Anatolian Current Medical Journal
JO  - Anatolian Curr Med J / ACMJ / acmj
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2718-0115
SP  - 492
EP  - 495
VL  - 7
IS  - 4
LA  - en
AB  - Aims: Adenoidal hypertrophy is a major contributor to upper airway obstruction and sleep-disordered breathing in children. Although intranasal corticosteroids (INCS) are clinically effective in alleviating symptoms, their histopathological effects on adenoidal tissue remain underexplored. This study aimed to evaluate the histopathological changes in adenoidal tissue following preoperative intranasal mometasone furoate therapy in pediatric patients undergoing adenoidectomy.Methods: This retrospective cross-sectional study included 96 children aged 2–18 years who underwent adenoidectomy between 2022 and 2024. Patients were divided into two groups: group 1 (no steroid therapy) and group 2 (received intranasal mometasone furoate 100 mcg/day for six weeks preoperatively). All patients used saline nasal irrigation during the same period. Adenoidal tissue samples were assessed histopathologically using semi-quantitative scoring (0–3) for follicular hyperplasia, chronic inflammation, acute inflammation, and goblet cell hyperplasia. Binary parameters including fibrosis, atrophy, ulceration, and hemorrhage were also evaluated.  Results: Group 2 exhibited significantly lower levels of follicular hyperplasia (median score 1.0 vs. 3.0, p
KW  - Adenoid hypertrophy
KW  - mometasone furoate
KW  - intranasal corticosteroids
KW  - histopathology
KW  - adenoidectomy
N2  - Aims: Adenoidal hypertrophy is a major contributor to upper airway obstruction and sleep-disordered breathing in children. Although intranasal corticosteroids (INCS) are clinically effective in alleviating symptoms, their histopathological effects on adenoidal tissue remain underexplored. This study aimed to evaluate the histopathological changes in adenoidal tissue following preoperative intranasal mometasone furoate therapy in pediatric patients undergoing adenoidectomy.Methods: This retrospective cross-sectional study included 96 children aged 2–18 years who underwent adenoidectomy between 2022 and 2024. Patients were divided into two groups: group 1 (no steroid therapy) and group 2 (received intranasal mometasone furoate 100 mcg/day for six weeks preoperatively). All patients used saline nasal irrigation during the same period. Adenoidal tissue samples were assessed histopathologically using semi-quantitative scoring (0–3) for follicular hyperplasia, chronic inflammation, acute inflammation, and goblet cell hyperplasia. Binary parameters including fibrosis, atrophy, ulceration, and hemorrhage were also evaluated.  Results: Group 2 exhibited significantly lower levels of follicular hyperplasia (median score 1.0 vs. 3.0, p
CR  - Kheirandish-Gozal L, Serpero LD, Dayyat E, et al. Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnoea. Eur Respir J. 2009;33(5):1077-1084. doi:10.1183/09031936. 00130608
CR  - Babakurban ST. Adenoidectomy: current approaches and review of the literature. Kulak Burun Bogaz Ihtis Derg. 2016;26(3):181-190. doi:10. 5606/kbbihtisas.2016.32815
CR  - Ahmed MR, Abou-Halawa AS, Ibrahim IH, Zittoon RF, Makary EFY. Effect of topical mometasone furoate on adenoidal lymphoid tissue: a light microscopic study. J Laryngol Otol. 2019;133(2):106-109. doi:10. 1017/S0022215118002268
CR  - Akcan FA, Bayram Akcan H, Dundar Y, Uluat A, Karakuş E. The Histopathological findings of adenoid tissue after topical mometasone furoate implementation. Konuralp Tıp Dergisi. 2018;10(2):203-207. doi: 10.18521/ktd.365710
CR  - Sadeghi-Shabestari M, Naderpoor M, Farzipour S, Dastranji A. The role of intranasal corticosteroid therapy in pediatric adenoidal hypertrophy: a randomized clinical trial study. Immunol Genet J. 2021;4(3):161-165 doi:10.18502/igj.v4i3.12116
CR  - Yilmaz HB, Celebi S, Sahin-Yilmaz A, Oysu C. The role of mometasone furoate nasal spray in the treatment of adenoidal hypertrophy in the adolescents: a prospective, randomized, cross-over study. Eur Arch Otorhinolaryngol. 2013;270(10):2657-2661. doi:10.1007/s00405-013-2364-9
CR  - Arslan E, Tulaci KG, Canakci H, Arslan S, Yazici H. Evaluation of the intranasal steroid treatment outcomes in adenoid tissue hypertrophy with or without allergic rhinitis. Am J Otolaryngol. 2021;42(4):102983. doi:10.1016/j.amjoto.2021.102983
CR  - Bilgili AM, Durmaz HÖ, Dilber M. Eustachian tube dysfunction in children with adenoid hypertrophy: the effect of intranasal azelastine-fluticasone spray treatment on middle ear ventilation and adenoid tissue. Ear Nose Throat J. 2023;102(3):198-203. doi:10.1177/01455613221140281
CR  - Zwierz A, Masna K, Domagalski K, Burduk P. The long-term effects of 12-week intranasal steroid therapy on adenoid size, its mucus coverage and otitis media with effusion: a cohort study in preschool children. JCM. 2022;11(3):507. doi:10.3390/jcm11030507
CR  - Ras AE, Hamed MH, Abdelalim AA. Montelukast combined with intranasal mometasone furoate versus intranasal mometasone furoate; a comparative study in treatment of adenoid hypertrophy. Am J Otolaryngol. 2020;41(6):102723. doi:10.1016/j.amjoto.2020.102723
CR  - Ezzat WF, Elczz TAA, Marouf AM, Ahmed EM. Nasal steroids use in the prevention of symptomatizing adenoid regrowth after adenoidectomy. QJM. 2021;114(Supplement_1):hcab094-008.
UR  - https://doi.org/10.38053/acmj.1713707
L1  - https://dergipark.org.tr/tr/download/article-file/4933969
ER  -