TY  - JOUR
T1  - Quantitative Analysis of Dioxins and Dioxin-like Polychlorinated Biphenyls in İnci Kefali (Alburnus tarichi, Güldenstädt, 1814): Implications for Public Health Risk Assessment
TT  - İnci Kefali (Alburnus tarichi, Güldenstädt, 1814)'nde Dioksin ve Dioksin Benzeri Poliklorlu Bifenillerin Kantitatif Analizi: Halk Sağlığı Risk Değerlendirmesi Açısından Sonuçları
AU  - Aydin, Funda
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.52976/vansaglik.1726636
JF  - Van Sağlık Bilimleri Dergisi
JO  - Van Sağ Bil Derg
PB  - Van Yüzüncü Yıl Üniversitesi
WT  - DergiPark
SN  - 2667-5072
SP  - 131
EP  - 138
VL  - 18
IS  - 2
LA  - en
AB  - Objective: Polychlorinated dibenzo-p-dioxin and furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) classified as persistent organic pollutants can enter the human food chain, especially through animal-based products like fish, and pose significant toxicological risks. The inci kefali (Alburnus tarichi, Güldenstädt, 1814) an endemic species in Lake Van, is a widely consumed fish by the local population. Therefore, assessing the levels of these pollutants in inci kefali is of considerable importance for public health monitoring and risk assessment. Material and Method: In this study, a total of 30 inci kefali specimens were collected from ten different local fishers in Van Province. Sample preparation was performed in an accredited laboratory authorized by the Turkish Ministry of Agriculture, following EPA standard methods. PCDD/Fs, dl-PCBs, and indicator PCBs were analyzed by APGC-MS/MS using isotope dilution with ¹³C-labeled internal standards. Results: The mean concentrations of PCDD/Fs, PCDD/Fs + dl-PCBs and indicator PCBs in the analyzed samples were found to be 0.056 ± 0.008 pgWHO-TEQ/g wet weight, 0.220 ± 0.019 pgWHO-TEQ/g wet weight and 0.135 ± 0.010 ng/g wet weight, respectively. The Tolerable Daily Intake (TDI) and Tolerable Weekly Intake (TWI) were calculated as 0.063 pgWHO-TEQ/kg body weight/day and 0.440 pgWHO-TEQ/kg body weight/week, respectively. Conclusion: The results show that PCDD/Fs, PCDD/Fs + dl-PCBs, and indicator PCBs in inci kefali samples obtained from Lake Van are well below the legal limits set by the European Commission and the Turkish Food Codex. Furthermore, TDI and TWI values were also found to be below the limits set by the European Food Safety Authority. These findings show that inci kefali consumption does not currently pose a significant health risk to human health
KW  - Dioxins
KW  - Dioxin-like polychlorinated biphenyls
KW  - İnci kefali
KW  - APGC-MS/MS
N2  - In this study, a total of 30 İnci Kefali (Alburnus tarichi Güldenstädt, 1814) specimens were collected from ten different local fishers in Van Province and analyzed for polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), dioxin-like polychlorinated biphenyls (dl-PCBs), and indicator PCBs (ICES-6: PCB28, PCB52, PCB101, PCB138, PCB153, PCB180) using APGC-MS/MS. The mean concentration of PCDD/Fs in the analyzed samples was determined as 0.056 ± 0.008 pg WHO-TEQ/g wet weight, while the total PCDD/F + dl-PCB concentration was 0.220 ± 0.019 pg WHO-TEQ/g wet weight. The total concentration of indicator PCBs (ICES-6) was measured as 0.135 ± 0.01 ng/g wet weight. When compared with the maximum permissible limits set by the European Commission (Commission Regulation (EU) 2023/915) and the Turkish Food Codex, the detected PCDD/F + dl-PCB levels correspond to only 3.4% of the legal limit. Similarly, the ICES-6 concentration represents approximately 0.2% of the maximum residue limits defined in the relevant regulations. Additionally, the estimated TDI (tolerable daily intake) and TWI (tolerable weekly intake) values were calculated as 0.01486 pg TEQ/kg/day and 0.104 pg TEQ/kg/week, respectively. These values are significantly below the limits recommended by EFSA (2018), which are 0.29 pg TEQ/kg/day for TDI and 2 pg TEQ/kg/week for TWI. The findings indicate that the levels of PCDD/F and dlPCBs, as persistent organic pollutants, in Alburnus tarichi pose no significant risk to public health and remain within safe limits.
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UR  - https://doi.org/10.52976/vansaglik.1726636
L1  - https://dergipark.org.tr/tr/download/article-file/4988356
ER  -