@article{article_1727150, title={Development of Mirtazapine Loaded Transdermal Drug Delivery System}, journal={Fabad Eczacılık Bilimler Dergisi}, volume={50}, pages={671–688}, year={2025}, DOI={10.55262/fabadeczacilik.1727150}, author={Karabudak, Özlem and Yener, Gülgun and Kul, Aykut and Yılmaz, Ece Merve}, keywords={mirtazapin, transdermal film, transdermal yama, antidepresan, oleik asit}, abstract={Transdermal drug delivery systems are dosage forms that can deliver the active drug substance subcutaneously into the systemic circulation. Mirtazapine alpha-2 receptor antagonist is an atypical antidepressant drug. The oral bioavailability of Mirtazapine is limited to 50%. When taken orally, it causes side effects such as sedation, weight gain and dry mouth. In this study, transdermal film formulations of Mirtazapine were designed, which could have a better bioavailability profile and higher patient compliance. Films have matrix type structure in which HPMC, HEC and PVP K30 are used as polymers and PEG 400 as plasticizer. The prepared films have been proven to be stable by physical tests and FT-IR analysis. It has been experimentally obtained that in the best formulation, Mirtazapine can be released for more than 24 hours and 14.41% of the drug in the dosage form permeates cumulatively through the artificial membrane within 24 hours. With the addition of oleic acid to the formulation, an 11.53% increase in permeation through the artificial membrane was achieved.}, number={3}, publisher={FABAD Ankara Eczacılık Bilimleri Derneği}, organization={İstanbul Üniversitesi}