TY  - JOUR
T1  - Assessing the role of inflammatory and nutritional biomarkers in the diagnosis of celiac disease
TT  - Çölyak hastalığının tanısında inflamatuvar ve nütrisyonel biyobelirteçlerin rolünün değerlendirilmesi
AU  - Mercantepe, Filiz
AU  - Çiftel, Enver
AU  - Atlı, Hasan
AU  - Dayanan, Ramazan
AU  - Genç, Selin
PY  - 2025
DA  - July
Y2  - 2025
DO  - 10.38053/acmj.1732459
JF  - Anatolian Current Medical Journal
JO  - Anatolian Curr Med J / ACMJ / acmj
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2718-0115
SP  - 506
EP  - 512
VL  - 7
IS  - 4
LA  - en
AB  - Aims: Celiac disease (CeD) is an immune-mediated enteropathy with multisystem involvement that is often underdiagnosed due to variable clinical manifestations. Identifying reliable, accessible, and noninvasive biomarkers is essential for timely diagnosis, particularly in resource-limited settings. This study aims to evaluate the diagnostic utility of inflammation and nutrition-related indices and scores calculated from routine laboratory tests in predicting CeD. Methods: This retrospective cross-sectional study included 79 biopsy-confirmed celiac patients and 60 healthy controls. Demographic, hematological, and biochemical data were collected. The platelet-to-lymphocyte ratio (PLR), triglycerideglucose index (TyG), hemoglobin, albumin, lymphocyte, and platelet (HALP) score, and other inflammation-related indices were calculated via validated formulas. Logistic regression analysis was performed to identify independent predictors of CeD. Receiver operating characteristic (ROC) curves were used to assess diagnostic performance. Results: Compared with controls, patients with CeD had significantly greater PLRs and lower TyG indices and HALP scores (p
KW  - Celiac disease
KW  - PLR
KW  - TyG index
KW  - HALP score
KW  - biomarkers
KW  - inflammation
KW  - nutrition
N2  - Arka Plan: Çölyak hastalığı (ÇH), çoklu sistemleri etkileyen ve klinik belirtilerin değişkenliği nedeniyle sıklıkla tanı konulamayan, immün aracılı bir enteropatidir. Güvenilir, erişilebilir ve invaziv olmayan biyobelirteçlerin tanımlanması, özellikle kaynakların kısıtlı olduğu ortamlarda zamanında tanı koymak için kritik öneme sahiptir. Amaç: Bu çalışmanın amacı, rutin laboratuvar testlerinden hesaplanan inflamasyon ve beslenme ile ilişkili indeks ve skorların çölyak hastalığını öngörmedeki tanısal değerini değerlendirmektir. Yöntemler: Bu kesitsel çalışmaya biyopsi ile doğrulanmış 79 çölyak hastası ve 60 sağlıklı kontrol dahil edilmiştir. Demografik, hematolojik ve biyokimyasal veriler toplanmıştır. Trombosit-lenfosit oranı (PLR), trigliserid-glukoz indeksi (TyG), hemoglobin, albümin, lenfosit ve trombosit (HALP) skoru ile diğer inflamasyonla ilişkili indeksler doğrulanmış formüllerle hesaplanmıştır. ÇH için bağımsız prediktörleri belirlemek amacıyla lojistik regresyon analizi yapılmıştır. Tanısal performansı değerlendirmek için ROC (alıcı işletim karakteristikleri) eğrileri kullanılmıştır. Bulgular: Kontrollerle karşılaştırıldığında, çölyak hastalarında PLR anlamlı derecede yüksek, TyG indeksi ve HALP skoru ise anlamlı derecede düşük bulunmuştur (tümünde p
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UR  - https://doi.org/10.38053/acmj.1732459
L1  - https://dergipark.org.tr/tr/download/article-file/5013280
ER  -