@article{article_1732505, title={Serum Soluble Urokinase Plasminogen Activator Receptor as a Prognostic Biomarker in Children with Chronic Kidney Disease Due to Congenital Anomalies of the Kidney and Urinary System}, journal={Journal of Cukurova Anesthesia and Surgical Sciences}, volume={8}, pages={271–275}, year={2025}, author={Gençler, Aylin and Taşkın, Seyhan}, keywords={Çözünür Ürokinaz Plazminojen Aktivatör Reseptörü (suPAR), Kronik Böbrek Hastalığı (KBH), Konjenital Böbrek ve Üriner Sistem Anomalileri (CAKUT), Çocuk, Tahmini Glomerüler Filtrasyon Hızı (eGFR)}, abstract={Introduction: This study aimed to evaluate the relationship between serum soluble urokinase plasminogen activator receptor (suPAR) levels and chronic kidney disease (CKD) stages in children with CAKUT, the leading cause of pediatric CKD. Metarials and Methods: Forty-two children with CAKUT-related CKD and 42 healthy controls were prospectively enrolled. Serum suPAR levels, estimated glomerular filtration rate (eGFR), and other laboratory parameters were compared. ROC analysis was used to assess the diagnostic performance of suPAR. Results: suPAR levels were significantly higher in the patient group (p <0.001) and increased with CKD severity. A suPAR cut-off of ≥3.38 ng/mL predicted CKD with 85.7% sensitivity and 78.6% specificity. suPAR showed a negative correlation with eGFR and a positive correlation with creatinine and potassium levels. Conclusion: Elevated suPAR levels may reflect CKD progression in children with CAKUT and serve as a non-invasive biomarker for early detection and disease monitoring.}, number={3}, publisher={Merthan TUNAY}