TY  - JOUR
T1  - Impact of Inflammatory Bowel Disease on Pulmonary Hemodynamics and Right Ventricular Function: The Role of Pulmonary Pulse Transit Time in Assessing Pulmonary Stiffness and Right Ventricular Function
TT  - İnflamatuvar Bağırsak Hastalığının Pulmoner Hemodinami ve Sağ Ventrikül Fonksiyonu Üzerine Etkisi: Pulmoner Pulse Transit Time’ın Pulmoner Stiffness ve Sağ Ventrikül Fonksiyonunun Değerlendirilmesindeki Rolü
AU  - Erbay, İlke
AU  - Eriş Güdül, Naile
AU  - Aladağ, Pelin
AU  - Ceylan, Güray
AU  - Aydemir, Selim
AU  - Avcı, Ahmet
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.29058/mjwbs.1733471
JF  - Medical Journal of Western Black Sea
JO  - Med J West Black Sea
PB  - Zonguldak Bülent Ecevit Üniversitesi
WT  - DergiPark
SN  - 2822-4302
SP  - 255
EP  - 264
VL  - 9
IS  - 2
LA  - en
AB  - Aim: Inflammatory bowel disease (IBD) is a chronic disease with systemic implications, including cardiovascular effects. The aim of thisstudy was to investigate the impact of IBD on right ventricular (RV) function and pulmonary hemodynamics, focusing on the relationshipbetween pulmonary pulse transit time (pPTT) and other echocardiographic markers.Material and Methods: Fifty IBD patients and 50 matched healthy controls underwent echocardiographic evaluation to assess RV function,including parameters such as RV myocardial performance index (RVMPI), RV ejection fraction (RV EF) and tricuspid annular plane systolicexcursion (TAPSE). Pulmonary hemodynamics were assessed by pPTT and pulmonary arterial stiffness (PAS). Statistical analyses exploredthe associations between IBD and these echocardiographic parameters.Results: No differences in systolic pulmonary artery pressure (sPAP) or TAPSE were observed between the groups. PAS was increasedand pPTT was shortened in IBD patients compared to controls. pPTT correlated with PAS, IBD duration, RV EF, RV fractional area change(RVFAC), TAPSE, tricuspid S', RVMPI and C-reactive protein (CRP). pPTT was an independent predictor of PAS (p  < 0.001).Conclusion: IBD patients show impaired RV function and increased pulmonary stiffness. pPTT may serve as a practical marker for earlydetection of pulmonary vascular changes in IBD, replacing PAS for hemodynamic assessment.
KW  - Inflammatory bowel disease
KW  - right ventricular function
KW  - pulmonary pulse transit time
KW  - pulmonary arterial stiffness
N2  - Amaç: İnflamatuvar bağırsak hastalığı (İBH), sistemik etkileri olan kronik bir hastalık olup kardiyovasküler sistemi de etkileyebilmektedir. Buçalışmada, İBH’nin sağ ventrikül (SV) fonksiyonları ve pulmoner hemodinami üzerindeki etkileri araştırılmış; özellikle pulmoner pulse transittime (pPTT) ile diğer ekokardiyografik göstergeler arasındaki ilişki incelenmiştir.Gereç ve Yöntemler: Çalışmaya 50 İBH hastası ile yaş ve cinsiyet açısından eşleştirilmiş 50 sağlıklı kontrol birey dahil edildi. Tümkatılımcılarda ekokardiyografi ile SV fonksiyonları değerlendirildi. Bu kapsamda SV miyokardiyal performans indeksi (SVMPI), SV ejeksiyonfraksiyonu (SV EF) ve triküspit anüler düzlem sistolik ekskursiyonu (TAPSE) gibi parametreler analiz edildi. Pulmoner hemodinamikdeğerlendirme ise pPTT ve pulmoner arteriyel stiffness (PAS) ölçümleri ile yapıldı. İBH ile bu ekokardiyografik parametreler arasındakiilişkiler istatistiksel olarak incelendi.Bulgular: Gruplar arasında sistolik pulmoner arter basıncı (sPAP) ve TAPSE açısından anlamlı fark bulunmazken, İBH hastalarında PASdüzeyleri belirgin şekilde artmış, pPTT süreleri ise anlamlı olarak kısalmıştı. pPTT; PAS, İBH süresi, SV EF, SV fraksiyonel alan değişimi(SVFAC), TAPSE, triküspit S', SVMPI ve C-reaktif protein (CRP) ile anlamlı korelasyon gösterdi. Ayrıca, pPTT’nin PAS üzerinde bağımsızbir belirleyici olduğu saptandı (p  < 0,001).Sonuç: İBH hastalarında sağ ventrikül fonksiyonlarında bozulma ve pulmoner damar sertliğinde artış gözlenmektedir. pPTT, pulmonervasküler değişikliklerin erken tanısında pratik ve erişilebilir bir belirteç olarak PAS’ın yerini alabilecek potansiyele sahiptir
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UR  - https://doi.org/10.29058/mjwbs.1733471
L1  - https://dergipark.org.tr/tr/download/article-file/5017359
ER  -