TY  - JOUR
T1  - Evaluation of the Gastroprotective Effects of Hazelnut Oil Against Ethanol-Induced Gastric Mucosal Injury in Rats
TT  - Fındık Yağının Etanol Kaynaklı Mide Mukozal Hasarına Karşı Gastroprotektif Etkilerinin Değerlendirilmesi
AU  - Akalin, Cagri
AU  - Ozdemir, Ozlem
AU  - Akcay Celik, Muruvvet
AU  - Karagulle, Onur Olgac
AU  - Noyan, Tevfik
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.56941/odutip.1737767
JF  - ODÜ Tıp Dergisi
JO  - ODU Tıp Derg
PB  - Ordu Üniversitesi
WT  - DergiPark
SN  - 2148-6816
SP  - 43
EP  - 54
VL  - 12
IS  - 2
LA  - en
AB  - This study aimed to investigate the gastroprotective effects of hazelnut oil against ethanol-induced gastric mucosal injury in rats by macroscopic and histopathological evaluations. Thirty-five male Wistar rats (180–220 g) were randomly divided into five groups (n=7): Control (saline), Ethanol (75% ethanol, 5 mL/kg), Hazelnut Oil-Low Dose (HO-L, 2.5 mL/kg hazelnut oil + ethanol), Hazelnut Oil-High Dose (HO-H, 5 mL/kg hazelnut oil + ethanol), and Ranitidine (50 mg/kg + ethanol). Treatments were administered orally for 7 days, followed by ethanol. Ulcer area, inhibition rate, and histopathological scores (inflammation, edema, epithelial damage, hemorrhage) were evaluated. Statistical analysis was performed using one-way ANOVA and Kruskal-Wallis tests. Ethanol induced significant gastric injury, while HO-L, HO-H, and Ranitidine groups showed significantly reduced ulcer areas (P  < 0.001) and histopathological scores (P  < 0.005). The highest inhibition was observed in the Ranitidine group (95%), followed by HO-H (78%) and HO-L (39%). Hazelnut oil exerts a dose-dependent protective effect against ethanol-induced gastric damage, likely due to its oleic acid and vitamin E content. These findings suggest hazelnut oil may serve as a natural alternative in the prevention of gastric ulcers.
KW  - Hazelnut oil
KW  - gastric mucosal injury
KW  - ethanol
KW  - gastroprotection
KW  - ulcer area
KW  - histopathology
N2  - Bu çalışmada, fındık yağının etanol ile oluşturulan mide mukozal hasarına karşı gastroprotektif etkileri makroskopik ve histopatolojik olarak değerlendirilmiştir. Otuz beş erkek Wistar sıçanı (180–220 g) rastgele beş gruba ayrıldı (n=7): Kontrol (salin), Etanol (%75 etanol, 5 mL/kg), Fındık Yağı-Düşük Doz (HO-L, 2.5 mL/kg fındık yağı + etanol), Fındık Yağı-Yüksek Doz (HO-H, 5 mL/kg fındık yağı + etanol) ve Ranitidin (50 mg/kg + etanol). Tedaviler 7 gün boyunca oral olarak uygulandı, ardından etanol verildi. Ülser alanı, inhibisyon oranı ve histopatolojik skorlar (inflamasyon, ödem, epitel hasarı, hemoraji) değerlendirildi. İstatistiksel analiz tek yönlü ANOVA ve Kruskal-Wallis testleriyle yapıldı. Etanol ciddi mide hasarı oluştururken, HO-L, HO-H ve Ranitidin grupları anlamlı derecede düşük ülser alanları (P  < 0.001) ve histopatolojik skorlar (P  < 0.005) gösterdi. En yüksek inhibisyon oranı Ranitidin grubunda (%95), ardından HO-H (%78) ve HO-L (%39) ile gözlendi. Fındık yağı, etanol kaynaklı mide hasarına karşı doza bağlı koruyucu etki göstermektedir. Bu etkinin oleik asit ve E vitamini içeriğinden kaynaklandığı düşünülmektedir. Elde edilen bulgular, fındık yağının mide ülserlerinin önlenmesinde doğal bir alternatif olabileceğini göstermektedir.
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UR  - https://doi.org/10.56941/odutip.1737767
L1  - https://dergipark.org.tr/tr/download/article-file/5035755
ER  -