TY - JOUR T1 - The relationshop between sleep quality and inflammatory and biochemical parameters in hemodialysis patients TT - Hemodiyaliz hastalarında uyku kalitesi ile inflamatuvar ve biyokimyasal parametreler arasındaki ilişki AU - Akgül, Arzu AU - Koç, Neriman Sıla AU - Aylı, Berrak Itır AU - Öztürk, Hakkı AU - Aylı, Mehmet Deniz PY - 2025 DA - September Y2 - 2025 DO - 10.38053/acmj.1739247 JF - Anatolian Current Medical Journal JO - Anatolian Curr Med J / ACMJ / acmj PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2718-0115 SP - 613 EP - 617 VL - 7 IS - 5 LA - en AB - Aims: This study aimed to evaluate the relationship between sleep quality and inflammatory and biochemical parameters in hemodialysis patients.Methods: In this cross-sectional, single-center study conducted in January 2025, a total of 195 patients aged 18 and older who had been undergoing hemodialysis treatment for at least six months were included. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI); scores ≤5 were classified as “good sleep,” and >5 as “poor sleep.” Demographic, clinical, and laboratory data were retrospectively collected. Following univariate comparisons, logistic regression analysis was performed to determine independent predictors of poor sleep quality. Results: Poor sleep quality was observed in 55% of the patients. In the univariate analysis, CRP, leukocytes, and CRP/albumin ratio were higher in poor sleepers, while hemoglobin, albumin, and HALP scores were lower (p KW - Hemodialysis KW - sleep quality KW - CRP KW - hemoglobin KW - biomarker N2 - Amaç: Bu çalışmada, hemodiyaliz hastalarında uyku kalitesi ile inflamatuvar ve biyokimyasal parametreler arasındaki ilişki değerlendirildi.Yöntem: Ocak 2025’te tek merkezli olarak yürütülen kesitsel çalışmaya, en az altı aydır hemodiyaliz tedavisi gören, 18 yaş ve üzeri toplam 195 hasta dahil edildi. Uyku kalitesi Pittsburgh Uyku Kalitesi İndeksi (PUKİ) ile ölçüldü; PUKİ ≤5 “iyi uyku”, PUKİ >5 “kötü uyku” olarak gruplandırıldı. Demografik, klinik ve laboratuvar verileri retrospektif olarak toplandı. Tek değişkenli analiz karşılaştırmaların ardından kötü uyku kalitesinin bağımsız belirleyicilerini saptamak için lojistik regresyon analizi gerçekleştirildi.Bulgular: Hastaların %55’inde kötü uyku kalitesi saptandı. Univaryant analizde kötü uyuyanlarda CRP, lökosit, CRP/Albümin oranı yüksek; hemoglobin, albümin ve HALP skoru düşük bulundu (p CR - Seyahi N, Kocyigit İ, Eren N, et al. Current status of kidney replacement therapy in Turkiye: a summary of 2022 Turkish Society of Nephrology registry report. Turk J Nephrol. 2024;33(2):134-139. doi:10.5152/turkjnephrol.2025.24978 CR - Pawar YS, Gattani VS, Chaudhari KS, Chheda B, Vankudre AJ. Impact of hemodialysis on sleep disorders in patients with end-stage renal disease in a tertiary care academic hospital. Cureus. 2023;15(8):e44416. doi:10.7759/cureus.44416 CR - Ezzat H, Mohab A. Prevalence of sleep disorders among ESRD patients. Ren Fail. 2015;37(6):1013-1019. doi:10.3109/0886022X.2015.1044401 CR - Iliescu EA, Coo H, McMurray MH, et al. Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant. 2003;18(1):126-132. doi:10.1093/ndt/18.1.126 CR - Belluardo G, Sessa C, Morale W. The alterations of sleep and frontal functions in chronic hemodialysis: pathogenesis and therapeutic perspectives. Behav Brain Res. 2025;478:115337. doi:10.1016/j.bbr.2024. 115337 CR - Turgay G, Tutal E, Sezer S. Restless legs syndrome, sleep quality and fatigue in hemodialysis patients. Turk Neph Dial Transplant. 2018;27(2): 196-203. CR - Elder SJ, Pisoni RL, Akizawa T, et al. Sleep quality predicts quality of life and mortality risk in haemodialysis patients: results from the dialysis outcomes and practice patterns study (DOPPS). Nephrol Dial Transplant. 2008;23(3):998-1004. doi:10.1093/ndt/gfm630 CR - Russcher M, Chaves I, Lech K, et al. An observational study on disturbed peripheral circadian rhythms in hemodialysis patients. Chronobiol Int. 2015;32(6):848-857. doi:10.3109/07420528.2015.1048868 CR - Razeghi E, Sahraian MA, Heidari R, Bagherzadeh M. Association of inflammatory biomarkers with sleep disorders in hemodialysis patients. Acta Neurol Belg. 2012;112(1):45-49. doi:10.1007/s13760-012-0003-7 CR - Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213. doi:10.1016/0165-1781 (89)90047-4 CR - Ağargün MY, Kara H, Anlar Ö. Pittsburgh uyku kalitesi indeksinin geçerligi ve güvenirligi. Turk Psikiyatri Dergisi. 1996;7:107-115. CR - Farag CM, Antar R, Akosman S, Ng M, Whalen MJ. What is hemoglobin, albumin, lymphocyte, platelet (HALP) score? A comprehensive literature review of HALP's prognostic ability in different cancer types. Oncotarget. 2023;14:153-172. doi:10.18632/oncotarget.28367 CR - Zhang F, Li L, Shi T, Liu Y, Xie J, Yu L. The hemoglobin, albumin, lymphocyte, and platelet (HALP) is a potent indicator for the prognosis in hemodialysis patients. Medicine (Baltimore). 2023;102(19):e33650. doi:10.1097/MD.0000000000033650 CR - Babovic B, Belada Babovic N, Tomovic F, et al. The importance of biochemical parameters, immunonutritional status, and social support for quality of life in chronic hemodialysis patients. Medicina (Kaunas). 2024;60(11):1751. doi:10.3390/medicina60111751 CR - Merlino G, Piani A, Dolso P, et al. Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant. 2006;21(1):184-190. doi:10.1093/ndt/gfi144 CR - Alshammari B, Alkubati SA, Pasay-An E, et al. Sleep quality and its affecting factors among hemodialysis patients: a multicenter cross-sectional study. Healthcare (Basel). 2023;11(18):2536. doi:10.3390/healthcare11182536 CR - Masoumi M, Naini AE, Aghaghazvini R, Amra B, Gholamrezaei A. Sleep quality in patients on maintenance hemodialysis and peritoneal dialysis. Int J Prev Med. 2013;4(2):165-172. CR - Chiu YL, Chuang YF, Fang KC, et al. Higher systemic inflammation is associated with poorer sleep quality in stable haemodialysis patients. Nephrol Dial Transplant. 2009;24(1):247-251. doi:10.1093/ndt/gfn439 CR - Taraz M, Khatami MR, Hajiseyedjavadi M, et al. Association between antiinflammatory cytokine, IL-10, and sleep quality in patients on maintenance hemodialysis. Hemodial Int. 2013;17(3):382-390. doi:10. 1111/hdi.12035 CR - Neumann SN, Li JJ, Yuan XD, et al. Anemia and insomnia: a cross-sectional study and meta-analysis. Chin Med J (Engl). 2020;134(6):675-681. doi:10.1097/CM9.0000000000001306 CR - Ghahremanfard F, Semnani MR, Mirmohammadkhani M, et al. The relationship between iron deficiency anemia with restless leg syndrome and sleep quality in workers working in a textile factory in Iran: a cross-sectional study. Middle East Curr Psychiatry. 2023;30(1):23. doi:10.1186/s43045-023-00294-5 CR - Liu R, Liu X, Zee PC, et al. Association between sleep quality and C-reactive protein: results from national health and nutrition examination survey, 2005-2008. PLoS ONE 2014;9(3):e92607. doi:10. 1371/journal.pone.0092607 UR - https://doi.org/10.38053/acmj.1739247 L1 - https://dergipark.org.tr/tr/download/article-file/5041625 ER -