TY  - JOUR
T1  - The effect of vitamin D replacement therapy on insulin resistance: a retrospective study
TT  - D vitamini replasman tedavisinin insülin direnci üzerine etkisi
AU  - Uskur, Tuğçe
AU  - Arıcan Tarım, Bahar
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.38053/acmj.1739961
JF  - Anatolian Current Medical Journal
JO  - Anatolian Curr Med J / ACMJ / acmj
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2718-0115
SP  - 647
EP  - 651
VL  - 7
IS  - 5
LA  - en
AB  - Aims: This study retrospectively evaluated the effect of a 3-month vitamin D replacement therapy in patients diagnosed with insulin resistance (IR) and low vitamin D levels. The relationship between changes in vitamin D levels and IR was investigated.Methods: A total of 98 patients with low serum vitamin D levels and HOMA-IR >2.5, who were admitted to the internal medicine outpatient clinic between January 1 and December 31, 2023, were included in this retrospective study. Sociodemographic characteristics and pre-and post-treatment biochemical parameters were obtained from medical records. Post-supplementation levels of vitamin D, glucose, insulin, and HOMA-IR were analyzed. Pre-and post-treatment values were compared using paired t-tests. The relationship between changes in vitamin D levels and HOMA-IR scores was assessed using Spearman correlation analysis.Results: Of the 98 patients, 85.7% were female and 14.3% were male, with a mean age of 39.09±11.45 years. A significant reduction in HOMA-IR score was observed after vitamin D supplementation (pre: 4.54±2.05; post: 3.01±1.28; p
KW  - Vitamin D
KW  - insulin resistance
KW  - HOMA-IR
KW  - diabetes
N2  - Giriş Bu çalışmada, D vitamini düzeyi düşük ve insülin direnci (IR) tanısı almış hastalarda 3 aylık D vitamini replasman tedavisinin HOMA-IR skoruna etkisi retrospektif olarak değerlendirilmiş, ayrıca D vitamini düzeyindeki değişimin insülin direnciyle ilişkisi incelenmiştir. Yöntem Çalışmaya 1 Ocak-31 Aralık 2023 tarihleri arasında D vitamini düzeyi düşük ve HOMA-IR >2.5 olan 98 hasta dahil edilmiştir. Hastaların sosyodemografik verileri ile tedavi öncesi ve sonrası biyokimyasal parametreleri dosya kayıtlarından elde edilmiştir. D vitamini takviyesi sonrası ölçülen D vitamini, glukoz, insülin düzeyleri ve HOMA-IR skorları değerlendirilmiş; öncesi ve sonrası değerler eşleştirilmiş t-testi ile karşılaştırılmıştır. Ayrıca D vitamini düzeyindeki değişim ile HOMA-IR skorundaki değişim arasındaki ilişki Spearman korelasyon analizi ile analiz edilmiştir. Bulgular Çalışmaya dahil edilen 98 hastanın %85.7’si kadın, %14.3’ü erkek olup yaş ortalaması 39.09±11.45 yıldır. D vitamini takviyesi sonrası HOMA-IR skorunda anlamlı bir azalma saptanmıştır (öncesi: 4.54±2.05; sonrası: 3.01±1.28; p
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UR  - https://doi.org/10.38053/acmj.1739961
L1  - https://dergipark.org.tr/tr/download/article-file/5044659
ER  -