@article{article_1740940, title={The impact of monocyte to HDL ratio and Prognostic Nutritional Index on survival in stage III colorectal cancer patients}, journal={Journal of Health Sciences and Medicine}, volume={8}, pages={805–810}, year={2025}, DOI={10.32322/jhsm.1740940}, author={Demir, Mehmet Salim and Yumak, Merve}, keywords={Monosit-HDL oranı, Prognostik Beslenme İndeksi, kolorektal kanser, evre III, sağkalım, prognostik belirteçler}, abstract={Aims: This study explores how systemic inflammatory and nutritional indicators, specifically the monocyte-to-high-density lipoprotein ratio (MHR) and Prognostic Nutritional Index (PNI), influence clinical outcomes in stage III colorectal cancer (CRC) patients. Methods: A retrospective review of 109 individuals was conducted. ROC curve analysis was employed to determine the optimal cut-off values of MHR and PNI for predicting mortality. Survival outcomes, including overall survival (OS) and disease-free survival (DFS), were evaluated using Kaplan-Meier estimates and compared with log-rank tests. Cox regression was utilized to pinpoint factors independently associated with DFS. Results: The findings revealed significantly lower OS among patients not undergoing adjuvant chemotherapy (45.6 vs. 82.2 months; p=0.002). Additionally, diminished MHR ( <0.37) and PNI ( <46.8) levels were linked to poorer OS (p=0.041 and p=0.003, respectively). While low PNI was also associated with reduced DFS (p=0.021), MHR did not significantly impact DFS (p=0.42). Both MHR (AUC: 0.643) and PNI (AUC: 0.657) demonstrated moderate predictive capabilities for mortality. Importantly, perineural invasion surfaced as an independent negative prognostic factor for DFS (HR: 2.36; p=0.038). Conclusion: In conclusion, pre-treatment MHR and PNI values serve as accessible and low-cost indicators that may assist in prognostic stratification in stage III CRC management.}, number={5}, publisher={MediHealth Academy Yayıncılık}