TY  - JOUR
T1  - The impact of monocyte to HDL ratio and Prognostic Nutritional Index on survival in stage III colorectal cancer patients
TT  - Evre III kolorektal kanser hastalarında monosit/HDL oranı ve Prognostik Beslenme İndeksinin sağkalıma etkisi
AU  - Demir, Mehmet Salim
AU  - Yumak, Merve
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.32322/jhsm.1740940
JF  - Journal of Health Sciences and Medicine
JO  - J Health Sci Med /JHSM /jhsm
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2636-8579
SP  - 805
EP  - 810
VL  - 8
IS  - 5
LA  - en
AB  - Aims: This study explores how systemic inflammatory and nutritional indicators, specifically the monocyte-to-high-density lipoprotein ratio (MHR) and Prognostic Nutritional Index (PNI), influence clinical outcomes in stage III colorectal cancer (CRC) patients.Methods: A retrospective review of 109 individuals was conducted. ROC curve analysis was employed to determine the optimal cut-off values of MHR and PNI for predicting mortality. Survival outcomes, including overall survival (OS) and disease-free survival (DFS), were evaluated using Kaplan-Meier estimates and compared with log-rank tests. Cox regression was utilized to pinpoint factors independently associated with DFS.Results: The findings revealed significantly lower OS among patients not undergoing adjuvant chemotherapy (45.6 vs. 82.2 months; p=0.002). Additionally, diminished MHR (
KW  - Monocyte-to-HDL ratio
KW  - Prognostic Nutritional Index
KW  - colorectal cancer
KW  - stage III
KW  - survival
KW  - prognostic markers
N2  - Amaç: Bu çalışma, sistemik inflamasyon ve beslenme durumunu yansıtan biyobelirteçler olan monosit/yüksek yoğunluklu lipoprotein oranı (MHR) ile prognostik beslenme indeksi (PNI)’nin, evre III kolorektal kanser (KRK) hastalarında klinik sonuçlara olan etkisini değerlendirmeyi amaçlamaktadır.Yöntemler: Toplam 109 hastanın retrospektif olarak değerlendirildiği bu çalışmada, MHR ve PNI için optimal eşik değerler ROC eğrisi analizi ile belirlendi. Genel sağkalım (OS) ve hastalıksız sağkalım (PFS) Kaplan-Meier yöntemiyle analiz edildi ve log-rank testi ile karşılaştırmalar yapıldı. PFS ile ilişkili bağımsız prognostik faktörler çok değişkenli Cox regresyon analiziyle belirlendi.Bulgular: Adjuvan kemoterapi almayan hastalarda genel sağkalım anlamlı ölçüde daha düşüktü (45.6 aya karşı 82.2 ay; p=0.002). Ayrıca, düşük MHR (
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UR  - https://doi.org/10.32322/jhsm.1740940
L1  - https://dergipark.org.tr/tr/download/article-file/5049131
ER  -