@article{article_1745156, title={Chemotherapy-Induced Cellular Senescence: A Comprehensive Review of Clinical Methodologies and Treatment Outcomes}, journal={Turkish Journal of Clinics and Laboratory}, volume={16}, pages={653–664}, year={2025}, DOI={10.18663/tjcl.1745156}, author={Yağbasan, Fatma Özge and Şimay Demir, Yaprak Dilber and Ark, Mustafa}, keywords={senesens, kanser, kemoterapi, biyobelirteç, klinik, tümör}, abstract={The phenomenon of cellular senescence, which inevitably occurs as a result of chemotherapy, which is the basis of today’s cancer treatment, has been a subject of increasing interest in recent years. This article aims to methodologically examine how cellular senescence is induced by chemotherapeutic agents and how this condition is detected in patients who are receiving or have received treatment. How senescent cells induced by chemotherapy during cancer treatment are determined, which biomarkers are used to detect senescence, and the methods used to detect these markers are discussed. In addition, the effects of senescent cells on the tumor microenvironment and the important clinical outcomes that may occur in patients with treatment are examined. In conclusion, in this review, we aimed to examine the clinical importance of cellular senescence induced by chemotherapy in cancer patients, how it may affect the response to chemotherapy, the side effects and long-term clinical outcomes it may cause in patients and possible new treatment methods to prevent potential adverse consequences.}, number={3}, publisher={DNT Ortadoğu Yayıncılık A.Ş.}