TY - JOUR T1 - Comorbidity burden and the role of hydroxychloroquine in venous thromboembolism risk among rheumatoid arthritis patients: a retrospective case-control study TT - Romatoid artrit hastalarında venöz tromboembolizm riskinde hidroksiklorokinin ve komorbiditenin rolü: retrospektif bir vaka-kontrol çalışması AU - Sandal Uzun, Güllü AU - Yücel, Ozan AU - Kaygusuz, Yunus AU - Bahap, Melda AU - Kiraz, Sedat AU - Ertenli, İhsan AU - Kılıç, Levent AU - Kalyoncu, Umut PY - 2025 DA - September Y2 - 2025 DO - 10.38053/acmj.1747743 JF - Anatolian Current Medical Journal JO - Anatolian Curr Med J / ACMJ / acmj PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2718-0115 SP - 597 EP - 601 VL - 7 IS - 5 LA - en AB - Aims: Patients with rheumatoid arthritis (RA) are at increased risk for venous thromboembolism (VTE). This study aims to identify clinical characteristics and treatment-related factors associated with VTE in RA patients.Methods: A retrospective analysis of 363 RA patients was conducted, including 34 RA patients with documented VTE. Demographics, comorbidities, and treatment data were compared between patients with and without VTE. Age-and sexmatched subgroup analysis and multivariate logistic regression were used to identify independent predictors of VTE. Results: The mean age of RA patients with VTE was 66.8 (11.5) and 30 (88.2) were female. VTE was significantly associated with older age, hypertension, hyperlipidemia, and higher Charlson Comorbidity Index (CCI). In the multivariate model, higher CCI was independently associated with VTE (OR 2.84, 95% CI: 1.46–3.80, p KW - Rheumatoid arthritis KW - venous thromboembolism KW - Charlson Comorbidity Index KW - hydroxychloroquine N2 - Giriş: Romatoid artrit (RA) hastaları, venöz tromboembolizm (VTE) açısından artmış risk altındadır. Bu çalışma, RA hastalarında VTE ile ilişkili klinik özellikleri ve tedaviyle ilişkili faktörleri belirlemeyi amaçlamaktadır.Yöntemler: VTE'si belgelenmiş 34 RA hastası da dahil olmak üzere 363 RA hastasının retrospektif analizi gerçekleştirilmiştir. Demografik özellikler, eşlik eden hastalıklar ve tedavi verileri, VTE'si olan ve olmayan hastalar arasında karşılaştırılmıştır. VTE'nin bağımsız öngörücülerini belirlemek için yaş ve cinsiyete göre eşleştirilmiş alt grup analizi ve çok değişkenli lojistik regresyon kullanılmıştır.Sonuçlar: VTE'si olan RA hastalarının ortalama yaşı 66,8 (11,5) olup, 30'u (88,2) kadındı. VTE, ileri yaş, hipertansiyon, hiperlipidemi ve daha yüksek Charlson Eşlik Eden Hastalık İndeksi (CCI) ile anlamlı şekilde ilişkiliydi. Çok değişkenli modelde, yüksek CCI, VTE ile bağımsız olarak ilişkiliydi (OR 2,84, %95 GA: 1,46-3,80, p < 0,001). Hidroksiklorokin kullanımı VTE ile negatif ilişkiliydi (OR 0,34, %95 GA: 0,10-0,86, p = 0,049). Diğer DMARD'lar ve glukokortikoidler bağımsız ilişki göstermedi.Sonuç: Yüksek komorbidite yükü, RA hastalarında VTE riskini önemli ölçüde artırırken, hidroksiklorokin koruyucu bir etki gösterebilir. Bu bulgular, kişiye özel komorbidite yönetiminin önemini vurgulamakta ve hidroksiklorokinin RA'da trombozun önlenmesinde potansiyel bir rolü olabileceğini düşündürmektedir. CR - Omair MA, Alkhelb SA, Ezzat SE, Boudal AM, Bedaiwi MK, Almaghlouth I. Venous thromboembolism in rheumatoid arthritis: the added effect of disease activity to traditional risk factors. Open Access Rheumatol. 2022;14:231-242. doi:10.2147/oarrr.S284757 CR - Menichelli D, Cormaci VM, Marucci S, et al. Risk of venous thromboembolism in autoimmune diseases: a comprehensive review. Autoimmun Rev. 2023;22(11):103447. doi:10.1016/j.autrev.2023.103447 CR - Ketfi C, Boutigny A, Mohamedi N, et al. Risk of venous thromboembolism in rheumatoid arthritis. 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Jama. 2012;308(13):1350-1356. doi:10.1001/2012.jama.11741 UR - https://doi.org/10.38053/acmj.1747743 L1 - https://dergipark.org.tr/tr/download/article-file/5077430 ER -