@article{article_1751695, title={Electrophysiology of pancreatic beta cells: a comprehensive review of ion channel function, electrical activity, and secretory mechanisms}, journal={Troia Medical Journal}, volume={6}, pages={83–96}, year={2025}, DOI={10.55665/troiamedj.1751695}, author={Oruç, Aykut and Oruç, Kadriye Yağmur and Cin, Semih and Seymen, Hakkı Oktay}, keywords={pankreatik beta hücreleri, insülin, elektrofizyoloji, KATP kanalları, BK kanalları, TRPM kanalları}, abstract={Pancreatic β-cells play a crucial role in maintaining glucose homeostasis through the regulation of insulin secre- tion. The electrophysiological properties of these cells, including ion channel function, electrical activity, and secretory mechanisms, are essential for their proper physiological function. In this comprehensive review, we provide an in-depth analysis of the electrophysiology of pancreatic β-cells. We discuss the various ion channels involved in the generation and modulation of electrical signals, such as voltage-gated ion channels, ATP-sensitive and delayed rectifier potassium ion channels, calcium ion channels, chloride channels and transient receptor poten- tial channels. Additionally, we examine the intricate interplay between intracellular calcium dynamics and insulin release. Furthermore, we explore the physiological and pathological factors that influence the electrophysiology of β-cells. A comprehensive understanding of the electrophysiological mechanisms governing pancreatic beta cell function is crucial for elucidating the pathogenesis of diabetes mellitus and developing novel therapeutic strategies.}, number={3}, publisher={Çanakkale Onsekiz Mart Üniversitesi}