TY  - JOUR
T1  - Sıçanların Kan ve Dalak Dokusu Üzerine Paladyum Klorür’ün Toksik Etkisi ve Kuersetin’in Koruyucu Rolü
TT  - Toxic Effect of Palladium Chloride on Blood and Spleen Tissue of Rats and Protective Role of Quercetin
AU  - Adıgüzel, Çağlar
AU  - Karaboduk, Hatice
AU  - Apaydın, Fatma Gökçe
AU  - Kalender, Yusuf
PY  - 2025
DA  - November
Y2  - 2025
DO  - 10.35229/jaes.1754345
JF  - Journal of Anatolian Environmental and Animal Sciences
JO  - JAES
PB  - Bülent VEREP
WT  - DergiPark
SN  - 2548-0006
SP  - 876
EP  - 882
VL  - 10
IS  - 6
LA  - tr
AB  - Paladyum son yıllarda endüstride kullanımı ciddi anlamda artan ve bunun sonucu olarak da halk sağlığı problemlerini meydana getiren bir ağır metaldir. Kuersetin antioksidan, anti-inflamatuar ve anti-kanser gibi özellikleri ile öne çıkan flavanol bir bileşiktir. Bu çalışmada paladyum klorürün (PdCl2) sıçanların kan ve dalak dokusunda yarattığı oksidatif hasara karşı kuersetinin (Que) korucu rolü araştırılmıştır. Her grupta 6 hayvan olacak şekilde 4 grup oluşturulmuştur. Kontrol grubu, Que grubu (30 mg/kg v.a.), PdCl2 grubu (8 mg/kg v.a.) ve Que+PdCl2 grubu. 28 gün boyunca uygulama maddeleri sıçanlara oral gavaj yoluyla verilmiştir. Deney sonunda PdCl2 uygulanan sıçanların kan ve dalak dokularındaki MDA miktarında kontrol grubundaki sıçanların MDA miktarına göre anlamlı bir artış meydana gelmiştir (p
KW  - Dalak
KW  - Kan
KW  - Kuersetin
KW  - Paladyum klorür
KW  - Oksidatif stres
N2  - Palladium is a heavy metal whose use in the industry has increased significantly in recent years, resulting in public health problems. Quercetin is a flavanol compound with antioxidant, anti-inflammatory and anticancer properties. In this study, the protective role of quercetin (Que) against the oxidative damage caused by palladium chloride (PdCl2) in the blood and spleen tissue of rats was investigated. Four groups were formed with 6 animals in each group. Control group, Que group (30 mg/kg bw), PdCl2 group (8 mg/kg bw) and Que+PdCl2 group. For 28 days, the administration substances were given to the rats by oral gavage. At the end of the experiment, there was a significant increase in the amount of MDA in the blood and spleen tissues of rats administered PdCl2 compared to the amount of MDA in the control group (p
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L1  - https://dergipark.org.tr/tr/download/article-file/5105654
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