TY  - JOUR
T1  - Evaluation of C-Reactive Protein Levels as Prognostic Indicators in Subarachnoid Hemorrhage Patients
TT  - Subaraknoid Kanama Hastalarında C-Reaktif Protein Düzeylerinin Prognostik Gösterge Olarak Değerlendirilmesi
AU  - Varol, Eyüp
AU  - Avcı, Furkan
AU  - Yaltırık, Cumhur Kaan
PY  - 2025
DA  - August
Y2  - 2025
DO  - 10.29058/mjwbs.1755419
JF  - Medical Journal of Western Black Sea
JO  - Med J West Black Sea
PB  - Zonguldak Bülent Ecevit Üniversitesi
WT  - DergiPark
SN  - 2822-4302
SP  - 293
EP  - 298
VL  - 9
IS  - 2
LA  - en
AB  - Aim: Subarachnoid hemorrhage (SAH) is a life-threatening condition often leading to severe complications such as cerebral vasospasm,delayed cerebral ischemia, and high mortality rates. Identifying reliable biomarkers to predict clinical outcomes can aid in improving patientmanagement and tailoring therapeutic interventions. This study aims to evaluate the prognostic value of C-reactive protein (CRP) levels inpredicting clinical outcomes, including functional recovery, incidence of vasospasm, and mortality, in SAH patients within the first 14 dayspost-hemorrhage Material and Methods: A retrospective analysis of 263 patients diagnosed with spontaneous SAH between 2018 and 2024 was conducted.Patients were classified into aneurysmal SAH (ASAH) and non-aneurysmal SAH (NASAH) groups based on digital subtraction angiographyfindings. CRP levels were measured daily for 14 days, and clinical outcomes were assessed using the Modified Rankin Scale and Kaplan-Meier survival analysis.Results: Patients with ASAH exhibited significantly higher CRP levels (median: 516 mg/L) and longer durations of CRP >100 mg/L comparedto NASAH patients. Higher CRP levels correlated positively with worse mRS scores and increased vasospasm incidence. Survival analysisrevealed that ASAH patients with CRP >200 mg/L had significantly reduced survival rates (45%) compared to those with lower CRP levels(72%, p  < 0.001).Conclusion: Elevated CRP levels are strongly associated with poor functional outcomes, increased vasospasm, and higher mortalityin SAH patients, particularly in those with aneurysmal rupture. Incorporating CRP monitoring into routine clinical practice may enhanceprognostication and guide targeted therapies
KW  - Subarachnoid hemorrhage
KW  - C-reactive protein
KW  - vasospasm
KW  - prognosis
KW  - biomarkers
N2  - Amaç: Subaraknoid kanama (SAK), genellikle ciddi komplikasyonlara yol açan ve yüksek mortalite oranlarına sahip, yaşamı tehdit edenbir durumdur. Klinik sonuçları öngörebilecek güvenilir biyobelirteçlerin tanımlanması, hasta yönetimini iyileştirmeye ve tedavi yaklaşımlarınıbireyselleştirmeye katkı sağlayabilir. Bu çalışmanın amacı, SAK hastalarında ilk 14 gün içinde C-reaktif protein (CRP) düzeylerinin fonksiyoneliyileşme, vazospazm insidansı ve mortalite gibi klinik sonuçları öngörmedeki prognostik değerini değerlendirmektir.Gereç ve Yöntemler: 2018 ile 2024 yılları arasında spontan SAK tanısı almış 263 hastanın retrospektif analizi yapıldı. Dijital subtraksiyonanjiyografi bulgularına göre hastalar anevrizmal SAK (ASAK) ve anevrizma dışı SAK (ADSAK) olarak sınıflandırıldı. CRP düzeyleri 14 günboyunca günlük olarak ölçüldü ve klinik sonuçlar Modifiye Rankin Skalası ve Kaplan-Meier sağkalım analizi ile değerlendirildi.Bulgular: ASAK hastalarında CRP düzeyleri anlamlı olarak daha yüksekti (medyan: 516 mg/L) ve CRP >100 mg/L süresi ADSAK hastalarınagöre daha uzundu. Yüksek CRP düzeyleri, daha kötü mRS skorları ve artmış vazospazm insidansı ile pozitif korelasyon gösterdi. Sağkalımanalizinde, CRP >200 mg/L olan ASAK hastalarının sağkalım oranı (%45), daha düşük CRP düzeyine sahip olanlara kıyasla (%72) anlamlıolarak daha düşüktü (p  < 0.001).Sonuç: Yüksek CRP düzeyleri, özellikle anevrizma rüptürü olan hastalarda, kötü fonksiyonel sonuçlar, artmış vazospazm ve yüksek mortaliteile güçlü bir şekilde ilişkilidir. CRP izleminin rutin klinik pratiğe dahil edilmesi, prognoz tahminini güçlendirebilir ve hedefe yönelik tedavilereyön verebilir.
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UR  - https://doi.org/10.29058/mjwbs.1755419
L1  - https://dergipark.org.tr/tr/download/article-file/5110104
ER  -