TY - JOUR T1 - Prognostic factors and treatment of patients with chondrosarcoma: a single institutional experience TT - Kondrosarkomlu hastaların prognostik faktörleri ve tedavisi: kurumsal deneyim AU - Önder, Tuğba AU - Yalçıntaş, Ülkü AU - Ateş, Öztürk AU - Alkış, Necati PY - 2025 DA - September Y2 - 2025 DO - 10.38053/acmj.1756949 JF - Anatolian Current Medical Journal JO - Anatolian Curr Med J / ACMJ / acmj PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2718-0115 SP - 657 EP - 664 VL - 7 IS - 5 LA - en AB - Aims: Prognostic factors and treatment modalities in chondrosarcoma (CS) remain poorly defined. This study aimed to present our institutional experience with CS patients.Methods: We retrospectively reviewed the medical records of 69 CS patients treated at our Cancer Institute between 2010 and 2023.Results: Median age at diagnosis was 47 years, with a slight male predominance (52%) and a median follow-up of 93 months. Grade 1 (34%) and grade 2 (34%) tumors were most common, predominantly affecting the lower extremities (40%) and pelvis (26%). At presentation, 63 patients had localized disease and 6 had metastases; metastases later developed in 13 additional patients, most frequently in the lungs. All 63 patients with localized disease underwent surgery, and 7 received adjuvant chemotherapy (CT). Recurrence developed in 26 patients, of whom 9 were treated with systemic therapy. Among 6 patients with stage IV disease, 5 underwent palliative surgery and received CT. The most commonly used regimens included doxorubicin based CT, pazopanib, sirolimus, and celecoxib. Among patients who developed metastasis during follow-up, 12/13 died. The median time from diagnosis to metastasis was 17.0 months (95% CI: 10.8–23.1), and median survival thereafter was 21.0 months (95% CI: 12.7–29.2). All six patients metastatic at presentation died, with a median progression-free survival of 7.0 months (95% CI: 2.1–11.8) and OS of 12.0 months (95% CI: 0.0–33.6). OS was 75%, 63%, and 57% at 5, 10, and 15 years, respectively. Female sex, low–intermediate grade, and stage I–II disease correlated with better OS in univariate analysis, but only stage at diagnosis remained significant in multivariate analysis (p=0.002). Conclusion: Our findings highlight that early tumor stage is the only independent predictor of overall survival, underscoring the critical importance of early diagnosis and timely intervention in CS. KW - Chemotherapy KW - surgery KW - radiotherapy KW - lung metastasis KW - chondrosarcoma N2 - Amaç ve Hedefler: Kondrosarkom (KS) hastalarının prognostik faktörleri ve tedavi yöntemlerine ilişkin veriler sınırlıdır. KS hastalarımızla ilgili deneyimlerimizi sunmayı amaçladık.Gereç ve Yöntemler: 2010-2023 yılları arasında Kanser Enstitümüzde KS tanısı almış 69 hastanın tıbbi kayıtları retrospektif olarak incelendi.Bulgular: Ortanca yaş 47 idi; 93 aylık takipte hafif bir erkek predominansı (%52) gözlendi. Grade 1 (%34) ve 2 (%34) KS'ler en sık görülenlerdi ve alt ekstremiteler (%40) ve pelvis (%26) için bir eğilim vardı. 63 hasta lokalize hastalık, 6 hasta ise metastazla presente oldu. Takip sırasında 13 hastada daha metastaz görüldü. Akciğer en sık metastaz bölgesiydi.Lokalize hastalığı olan 63 hastanın tamamı ameliyat edildi; 7 hasta adjuvan kemoterapi (CT) aldı. 26 hastada nüks görüldü; 9 hasta sistemik kanser tedavisi aldı. Evre 4 hastalık tanısı alan 6 hastanın 5 ine palyatif cerrahi uygulandı, 5 ine CT uygulandı. En sık kullanılan tedavi rejimleri doksorubisin bazlı CT, pazopanib, sirolimus ve selekoksib idi. Takip sırasında metastaz gelişen 13 hastanın 12'si hayatını kaybetti; tanıdan metastaza kadar geçen medyan süre 17,0 (95% CI: 10,8-23,1) ve metastaz sonrası medyan sağ kalım 21,0 (95% CI: 12,7-29,2) aydı. Başlangıçta metastatik olan altı hastanın tamamı hayatını kaybetmişti; medyan progresyonsuz sağ kalım 7 (95% CI: 2,1-11,8) ve genel sağ kalım (OS) 12 (95% CI: 0,00-33,60) aydı.OS, tüm grup için sırasıyla 5, 10 ve 15. yıllarda %75, %63 ve %57 idi. Tek değişkenli analizde kadın cinsiyet, düşük-orta grade, evre 1-2 tümörler uzamış OS ile ilişkiliydi. Çok değişkenli analizde, tanı anındaki evre OS için tek anlamlı faktördü (p=0,002).Sonuç: Yapılan analizler, tümörün erken evrede olmasının iyileşmiş genel sağkalım için önemli bir faktör olduğunu ortaya koydu. CR - Chow W, Frankel P, Ruel C, et al. Results of a prospective phase 2 study of pazopanib in patients with surgically unresectable or metastatic chondrosarcoma. 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Stat Med. 1999;18(6):695-706. doi:10.1002/(sici)1097-0258(19990330)18:6 <695::aid-sim60>3.0.co;2-o UR - https://doi.org/10.38053/acmj.1756949 L1 - https://dergipark.org.tr/tr/download/article-file/5116908 ER -