TY - JOUR T1 - Long-term regular exercise effect on retinal and choroidal structure: insights from real-life data TT - Uzun süreli düzenli egzersiz ve retinokoroidal yapı değişiklikleri: gerçek yaşam verilerl üzerine bir çalışma AU - Demir, Nur AU - Dalkılıç, Hasine Gözde AU - Kayhan, Belma AU - Tükel, Nurgül AU - Serindağ, Zeliha AU - Kaplan, Mustafa PY - 2025 DA - September Y2 - 2025 DO - 10.38053/acmj.1757798 JF - Anatolian Current Medical Journal JO - Anatolian Curr Med J / ACMJ / acmj PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2718-0115 SP - 635 EP - 641 VL - 7 IS - 5 LA - en AB - Aims: Exercise increases ocular perfusion pressure. The retina and choroid can autoregulate blood flow to a certain extent in response to this increase. Most of the studies have focused on short-term ophthalmologic effects of exercise and showed conflicting results. This study aimed to evaluate the long-term effects of regular exercise on retinal and choroidal structures, as well as the potential contribution of exercise-related systemic changes. Methods: Participants who had engaged in regular exercise for at least two years were included in the study group, while those who had not exercised were assigned to the control group. Clinical assessments included blood pressure, heart rate, body-mass index, HbA1c, complete blood count, lipid profile, thyroid-stimulating hormone, fT3, fT4, and C-reactive protein. Retinal and choroidal thicknesses in the right eye were measured using optical coherence tomography. Results: The trained group consisted of 36 participants and the untrained group included 35 participants. The mean duration of regular exercise was 4.29±2.5 years. Choroidal thickness was greater at all measured points in the trained group compared with controls, with significant differences at nasal (p KW - Cardiovascular risk factors KW - choroid KW - exercise KW - hematological parameters KW - real-life conditions KW - retina N2 - Amaç: Egzersiz göz kan perfüzyon basıncını artırır. Retina ve koroid, kan akışını belirli bir dereceye kadar otoregüle eder. Çalışmaların çoğu egzersizin kısa süreli oftalmolojik etkilerine odaklanmış ve çelişkili sonuçlar göstermiştir. Bu çalışma, egzersizin retina ve koroid üzerindeki etkilerini ve egzersizle değişen sistemik parametrelerin ek katkısını değerlendirmeyi amaçlamaktadır.Yöntem: En az 2 yıl egzersiz yapan katılımcılar çalışma grubunu ve egzersiz yapmayanlar kontrol grubunu oluşturdu. Kan basıncı, kalp hızı, vücut kitle indeksi, HbA1c, tam kan sayımı, lipid profili, tiroid uyarıcı hormon, serbest T4, serbest T3 ve C-reaktif protein analiz edildi. Sağ gözlerin retina katmanları ve koroidal kalınlıkları optik koherens tomografi ile değerlendirildi.Bulgular: Egzersiz yapan grup 36, kontrol grubu ise 35 katılımcıdan oluşuyordu. Düzenli egzersiz yapılan süre ortalaması 4,29±2,5 yıldı. Koroid kalınlığı, egzersiz grubunda, kontrol grubuna kıyasla nazal (p CR - Szalai I, Csorba A, Pálya F, et al. The assessment of acute chorioretinal changes due to intensive physical exercise in young adults. PLoS One. 2022;17(5):e0268770. doi:10.1371/journal.pone.0268770 CR - Risner D, Ehrlich R, Kheradiya NS, Siesky B, McCranor L, Harris A. Effects of exercise on intraocular pressure and ocular blood flow: a review. J Glaucoma. 2009;18(6):429-436. doi:10.1097/IJG.0b013e31818fa5f3 CR - Vo Kim S, Semoun O, Pedinielli A, Jung C, Miere A, Souied EH. Optical coherence tomography angiography quantitative assessment of exercise-induced variations in retinal vascular plexa of healthy subjects. 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