TY  - JOUR
T1  - Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü
AU  - Adıgüzel, Çağlar
AU  - Yayla, Müzeyyen Aybüke
PY  - 2025
DA  - November
Y2  - 2025
DO  - 10.63716/guffd.1759695
JF  - Gazi Üniversitesi Fen Fakültesi Dergisi
JO  - GÜFFD
PB  - Gazi Üniversitesi
WT  - DergiPark
SN  - 2757-5543
SP  - 384
EP  - 394
VL  - 6
IS  - 2
LA  - tr
AB  - Nikel oksit (NiO) endüstride sıklıkla kulanılan bir geçiş metalidir. Yaygın kullanımına bağlı olarak halk sağlığı ve çevre sorunları meydana gelmiştir. Resveratrol (RES) antioksidan aktiviteleri güçlü olan bir fenolik bileşikdir. Şu anki çalışma NiO’nun ratların akciğer dokusundaki yarattığı oksidatif ve histopatolojik hasara karşı RES’in koruyucu rolünü araştırmıştır. Çalışmada 4 grup (her grupta 6 hayvan) oluşturulmuştur. Kontrol grubu, RES grubu (10 mg/kg v.a.), NiO grubu (10 mg/kg v.a.) ve RES+NiO grubu. 28 günlük oral gavaj uygulaması sonrası NiO uygulanan ratların akciğer dokularındaki, nikel birikimi ve MDA miktarı konrol grubuna göre anlamlı bir yükselme göstermiştir (p<0,05). SOD, CAT, GPx ve GST gibi antioksidanlarda ise anlamlı bir azalma meydana gelmiştir (p<0,05). Ayrıca NiO uygulanan gruptaki ratların akciğer dokularında ciddi histopatolojik değişiklikler gözlenmiştir. RES ve NiO’nun beraber uygulandığı grupta nikel birikiminde ve MDA düzeyinde anlamlı bir azalma, antioksidan aktivitelerde ise anlamlı bir artma meydana gelmiştir. Aynı zamanda histopatolojik incelemede iyileşmeler gözlenmiştir. Bu sonuçlar RES’in önemli bir takviye gıda olduğunu göstermektedir.
KW  - Nikel oksit
KW  - Resveratrol
KW  - Akciğer
KW  - Oksidatif stres
KW  - Histopatoloji
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UR  - https://doi.org/10.63716/guffd.1759695
L1  - https://dergipark.org.tr/tr/download/article-file/5129494
ER  -