TY - JOUR T1 - Investigation Of The Effect Of Nutrition In Gynecologic Malignancy On The Early Genitourinary And Gastrointestinal Side Effects Profile Of Patients Receiving Pelvic Radiotherapy TT - Jinekolojik Malignitelerde Beslenmenin Pelvik Radyoterapi Alan Hastaların Erken Genitoüriner ve Gastrointestinal Yan Etki Profiline Etkisinin Araştırılması AU - Özdemir, Belma Gözde AU - Deli, Burak AU - Madinaeva, Anara AU - Başaran, Hamit AU - Yavas, Cagdas AU - Bilgi, Ahmet AU - Celik, Cetin PY - 2025 DA - September Y2 - 2025 JF - Türk Jinekolojik Onkoloji Dergisi JO - TRSGO Dergisi PB - Türk Jinekolojik Onkoloji Derneği WT - DergiPark SN - 2148-5372 SP - 56 EP - 65 VL - 25 IS - 2 LA - en AB - Aim: The The role of therapeutic or adjuvant radiotherapy in gynecological cancers is crucial. Genitourinary and gastrointestinal symptoms can occur in these diseases due to the anatomical relationships in the pelvic region. To prevent these complications, enriching the intestinal flora and microbiota, as well as providing supplementation with trace elements, vitamins, and minerals, has been shown to reduce side effects. This study aimed to investigate the early gastrointestinal and genitourinary side effect profiles in patients receiving nutritional support (NS) and radiotherapy.Material and Methods: Patients who presented to the Department of Obstetrics and Gynecology and Radiation Oncology Department at Selçuk University Faculty of Medicine between 2023 and 2024 and received pelvic radiotherapy for gynecological malignancy were evaluated. Nutritional support is routinely provided in the clinic, and the study was designed as a retrospective study. The Radiation Therapy Oncology Group’s Radiation Toxicity Index was used for side effect scoring. A total of 120 patients were included in the study. Based on nutritional support, Group 1 (n=60) included those who received nutritional support, and Group 2 (n=60) included those who did not receive nutritional support.Results: There was a difference in the distribution of genitourinary side effects among patients receiving radiotherapy according to their use of nutritional support (p<0.05). It was observed that the use of NS had the potential to reduce genitourinary side effects. There was a difference in the distribution of gastrointestinal side effects in patients receiving radiotherapy according to their NS use (p<0.05). Gastrointestinal side effects were less common in patients receiving NS.Conclusion: Nutritional support is thought to reduce genitourinary and gastrointestinal side effects in gynecologic cancer patients undergoing pelvic radiotherapy. Individualized approaches are essential, regardless of nutritional index. KW - radiotherapy KW - hysterectomy KW - side effect KW - nutrition KW - malignancy N2 - Giriş/Amaç: Jinekolojik kanserlerde radyoterapinin rolü çok önemlidir. Pelvik bölgedeki anatomik ilişkiler nedeniyle bu hastalıklarda genitoüriner ve gastrointestinal semptomlar ortaya çıkabilir. Bu çalışmada beslenme desteği (ND) alan hastalarda erken gastrointestinal ve genitoüriner yan etki profillerinin araştırılması amaçlanmıştır.Materyal ve Metod: Selçuk Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı'na 2023-2024 yılları arasında başvuran ve jinekolojik malignite tanısıyla pelvik radyoterapi alan hastalar değerlendirildi. Klinikte rutin olarak beslenme desteği verilmekte olup, çalışma retrospektif olarak tasarlandı. Yan etki skorlaması için Radyasyon Terapisi Onkoloji Grubu'nun Radyasyon Toksisite İndeksi kullanıldı. Çalışmaya toplam 120 hasta dahil edildi. Beslenme desteğine göre Grup 1 (n=60) beslenme desteği alanlar, Grup 2 (n=60) ise beslenme desteği almayan hastalardan oluşturuldu.Bulgular: Radyoterapi alan hastalarda beslenme desteği kullanımına göre genitoüriner yan etkilerin dağılımında farklılık görüldü (p<0,05). ND kullanımının genitoüriner yan etkileri azaltma potansiyeline sahip olduğu görüldü. Radyoterapi alan hastalarda ND kullanımına göre gastrointestinal yan etkilerin dağılımında farklılık görüldü (p<0,05). ND alan hastalarda gastrointestinal yan etkiler daha az yaygın olarak raporlandı.Sonuç: Pelvik radyoterapi uygulanan jinekolojik kanser hastalarında beslenme desteğinin genitoüriner ve gastrointestinal yan etkileri azalttığı düşünülmektedir. Beslenme indeksi ve ek hastalıklara göre kişiye özel yaklaşımlar esastır. CR - 1. Pritlove C, Capone G, Ramasamy M, et al. 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