@article{article_1762446, title={Stathmin-1 as a biomarker in preeclampsia: correlation with clinical severity}, journal={Journal of Medicine and Palliative Care}, volume={6}, pages={491–495}, year={2025}, author={Kayaoğlu Yıldırım, Zeynep and Bolluk, Gökhan and Zengi, Oğuzhan}, keywords={Stathmin-1, preeklampsi, STMN-1, trofoblast invazyonu}, abstract={Aims: Preeclampsia (PE) is a multisystem pregnancy disorder linked to abnormal placentation and significant maternal-fetal morbidity. Identifying reliable biomarkers that reflect placental dysfunction and disease severity remains clinically important. This study aimed to assess maternal serum levels of stathmin-1 (STMN-1), a regulator of cell proliferation and trophoblast invasion, in pregnancies complicated by PE with and without severe features, compared to healthy controls. Methods: This prospective, cross-sectional study included 81 pregnant women: 41 with PE (22 without severe features and 19 with severe features) and 40 normotensive healthy controls. Maternal serum STMN-1 levels were measured using a validated ELISA method. Clinical characteristics, perinatal outcomes, and laboratory findings were compared across groups. Results: STMN-1 levels were significantly lower in the PE group (5.99±3.37) than in controls (8.23±3.42)(p=0.004). Although not statistically significant (p=0.172), levels tended to be lower in PE without severe features compared to controls. STMN-1 levels were significantly lower in PE with severe features (4.88±2.96) than in PE without severe features (6.97±3.46, p=0.047) and controls (p=0.001). Conclusion: Maternal serum STMN-1 levels decrease in PE, particularly in severe cases. These findings suggest that STMN1 may serve as a useful biomarker for identifying and assessing the severity of PE. Further large-scale studies are needed to confirm its diagnostic and prognostic value.}, number={5}, publisher={MediHealth Academy Yayıncılık}