TY  - JOUR
T1  - Ratlarda Kadmiyum’un Sebep Olduğu Akciğer Toksisitesi Üzerine Berberin’in Koruyucu Rolü
AU  - Karaboduk, Hatice
AU  - Tütüncü, Kübra
PY  - 2025
DA  - November
Y2  - 2025
DO  - 10.63716/guffd.1762655
JF  - Gazi Üniversitesi Fen Fakültesi Dergisi
JO  - GÜFFD
PB  - Gazi Üniversitesi
WT  - DergiPark
SN  - 2757-5543
SP  - 265
EP  - 274
VL  - 6
IS  - 2
LA  - tr
AB  - Kadmiyum (Cd), birçok endüstriyel alanda kullanımıyla çevrede yaygın olarak bulunan oldukça toksik ağır metallerden birisidir ve hem insan hem de hayvan sağlığı açısından ciddi bir tehdit oluşturmaktadır. Berberin (BBR), antikanser antioksidan ve antiinflamatuar etkileri bulunan, bitkisel kaynaklı doğal bir antioksidandır. Bu çalışmada kadmiyum klorürün (CdCl2) ratların akciğer dokusunda yarattığı toksik etkiye karşı berberinin koruyucu rolü araştırılmıştır. Ratlar her grupta rastgele altı birey olacak şekilde 4 gruba ayrılmıştır. Kontrol grubu, BBR grubu (30 mg/kg v.a.), CdCl2 grubu (1,76 mg/kg v.a.) ve BBR+CdCl2 grubu. 28 günlük uygulama sonrasında, kontrol grubuna göre CdCl2 uygulanan ratların akciğer dokularında Cd birikiminde ve MDA seviyelerinde anlamlı bir artış, SOD, CAT, GST ve GPx antioksidan enzim aktivitelerinde ise anlamlı bir azalma gözlenmiştir (p
KW  - Kadmiyum klorür
KW  - Berberin
KW  - Akciğer
KW  - Oksidatif stres
KW  - Histopatoloji
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UR  - https://doi.org/10.63716/guffd.1762655
L1  - https://dergipark.org.tr/tr/download/article-file/5143410
ER  -