TY  - JOUR
T1  - The role of Vitamin D deficiency in neuropathic pain following Herpes Zoster: a retrospective cohort study
TT  - Herpes Zoster Sonrası Nöropatik Ağrıda D Vitamini Eksikliğinin Rolü: Retrospektif Kohort Çalışması
AU  - İlhan, Seher
AU  - Erdoğan, Çağla
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.18663/tjcl.1762842
JF  - Turkish Journal of Clinics and Laboratory
JO  - TJCL
PB  - DNT Ortadoğu Yayıncılık A.Ş.
WT  - DergiPark
SN  - 2149-8296
SP  - 545
EP  - 554
VL  - 16
IS  - 3
LA  - en
AB  - significantly impacts quality of life. In this context, the objective of this study is to investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and the severity, duration, and neuropathic symptoms of PHN.Material and Methods: The sample of this retrospective observational cohort study consisted of 71 patients who were followed up with a diagnosis of PHN between January 2020 and June 2024. Patients were stratified into three groups according to their serum 25(OH)D levels as patients with vitamin D deficiency (≤20 ng/mL, n=24), vitamin D insufficiency (21-29 ng/mL, n=26), and vitamin D sufficiency (≥30 ng/mL, n=21). Patients’ neuropathic pain was assessed using the Douleur Neuropathique 4 (DN4) questionnaire and the Numeric rating scale (NRS). Inflammatory parameters such as C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and leukocyte count were recorded for each patient, and the diagnostic performance of their serum 25(OH)D levels was evaluated by receiver operating characteristic (ROC) curve analysis.Results: The mean DN4 and NRS scores and pain duration of the patients with vitamin D deficiency were significantly higher than those of other patients (5.83±1.76 vs. 1.71±0.96, p
KW  - postherpetic neuralgia
KW  - vitamin D deficiency
KW  - DN4 score
KW  - neuropathic pain
KW  - herpes zoster
N2  - Amaç: Postherpetik nevralji (PHN), herpes zoster enfeksiyonunun yaşam kalitesini önemli ölçüde etkileyen en yaygın komplikasyonudur. Bu bağlamda, bu çalışmanın amacı serum 25-hidroksivitamin D [25(OH)D] düzeyleri ile PHN'nin şiddeti, süresi ve nöropatik semptomları arasındaki ilişkiyi araştırmaktır.Gereç ve Yöntemler: Bu retrospektif gözlemsel kohort çalışmasının örneklemi, Ocak 2020 ile Haziran 2024 arasında PHN tanısı ile takip edilen 71 hastadan oluşmaktadır. Hastalar serum 25(OH)D düzeylerine göre D vitamini eksikliği (≤20 ng/mL, n=24), D vitamini yetersizliği (21-29 ng/mL, n=26) ve D vitamini yeterliliği (≥30 ng/mL, n=21) olan hastalar olarak üç gruba ayrılmıştır. Hastaların nöropatik ağrıları nöropatik ağrı 4 (DN4) anketi ve Numerik derecelendirme ölçeği (NRS) kullanılarak değerlendirilmiştir. Her hasta için C-reaktif protein (CRP) düzeyi, eritrosit sedimentasyon hızı (ESR) ve lökosit sayısı gibi inflamatuar parametreler kaydedilmiş ve serum 25(OH)D düzeylerinin tanısal performansı alıcı işletim karakteristiği (ROC) eğrisi analizi ile değerlendirilmiştir.Bulgular: D vitamini eksikliği olan hastaların ortalama DN4 ve NRS skorları ile ağrı süreleri diğer hastalara göre anlamlı derecede yüksekti (5,83±1,76'ya karşı 1,71±0,96, p
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UR  - https://doi.org/10.18663/tjcl.1762842
L1  - https://dergipark.org.tr/tr/download/article-file/5144343
ER  -