TY  - JOUR
T1  - Electrophysiological evaluation of central and peripheral nerve conduction according to retinopathy level in type II diabetic patients
TT  - Retinopati düzeyine göre tip 2 diyabetli hastalarda santral ve periferik sinir iletiminin elektrofizyolojik değerlendirilmesi
AU  - Yılmaz, Buket
AU  - Özenç, Betül
AU  - Bayrak, Derya
AU  - Yenilmez Yeşildaş, Pelin
AU  - Gürbostan Soysal, Gizem
PY  - 2025
DA  - October
Y2  - 2025
JF  - Journal of Medicine and Palliative Care
JO  - J Med Palliat Care / JOMPAC / Jompac
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2717-7505
SP  - 476
EP  - 480
VL  - 6
IS  - 5
LA  - en
AB  - Aims: To evaluate central and peripheral nerve conduction in patients with type 2 diabetes mellitus (T2DM) using visual evoked potentials (VEP) and nerve conduction studies, and to investigate their relationship with diabetes duration and diabetic retinopathy severity. Methods: This retrospective cross-sectional study included 100 T2DM patients and 100 age- and sex-matched healthy controls. P100 latency was measured for central conduction, while distal latency, amplitude, and conduction velocity of the tibial, ulnar, and sural nerves were assessed for peripheral conduction. Statistical analyses included t-tests, Mann–Whitney U tests, Chi-square tests, ANOVA, Kruskal–Wallis tests, and Spearman’s correlations. Results: P100 latency was significantly prolonged in the diabetic group compared with controls (113.07±4.66 ms vs. 104.10±3.25 ms; p
KW  - Type 2 diabetes mellitus
KW  - visual evoked potentials
KW  - peripheral neuropathy
KW  - nerve conduction studies
KW  - diabetic 
retinopathy
N2  - Amaç: Tip 2 diyabetes mellitus (T2DM) hastalarında görsel uyarılmış potansiyel (VEP) ve sinir iletim çalışmaları kullanılarak santral ve periferik sinir iletimini değerlendirmek ve bu parametrelerin diyabet süresi ile diyabetik retinopati şiddetiyle ilişkisini araştırmak.Yöntem: Bu retrospektif kesitsel çalışmaya, 100 T2DM hastası ve yaş-cinsiyet uyumlu 100 sağlıklı kontrol dahil edilmiştir. Santral iletim için P100 latansı ölçülmüş, periferik iletim için tibial, ulnar ve sural sinirlerin distal latans, amplitüd ve ileti hızı parametreleri değerlendirilmiştir. İstatistiksel analizlerde t-testi, Mann–Whitney U testi, Ki-kare testi, ANOVA, Kruskal–Wallis testi ve Spearman korelasyon analizleri kullanılmıştır.Bulgular: P100 latansı, diyabet grubunda kontrol grubuna göre anlamlı derecede uzundu (113,07 ± 4,66 ms vs. 104,10 ± 3,25 ms; p
CR  - American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37 Suppl 1(Suppl 1):S81-S90. doi:10.2337/dc14-S081
CR  - Tesfaye S, Selvarajah D. Diabetic peripheral neuropathy: explanatory factors and clinical relevance. Diabetes Res Clin Pract. 2012;96(3):214-223. doi:10.1016/j.diabres.2012.10.015
CR  - Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010; 376(9735):124-136. doi:10.1016/S0140-6736(09)62124-3
CR  - Wilkinson CP, Ferris FL, Klein RE, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110(9):1677-1682. doi:10.1016/S0161-6420(03)00475-5
CR  - Miura G. Visual evoked potentials for the detection of diabetic retinal neuropathy. Int J Mol Sci. 2023;24(8):7361. doi:10.3390/ijms24087361
CR  - England JD, Gronseth GS, Franklin G, et al. Distal symmetric polyneuropathy: a definition for clinical research. Muscle Nerve. 2005; 31(1):113-123. doi:10.1002/mus.20259
CR  - Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Diabetes Care. 1978;1(3):168-188. doi:10.2337/diacare.1.3.168
CR  - Lövestam-Adrian M, Gränse L, Andersson G, Andreasson S. Multifocal visual evoked potentials (mfVEP) in diabetic patients with and without polyneuropathy. Open Ophthalmol J. 2012;6:98-103. doi:10.2174/ 1874364101206010098
CR  - Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes: prospective observational study. BMJ. 2000;321(7258):405-412. doi:10. 1136/bmj.321.7258.405
CR  - Tesfaye S, Boulton AJ, Dyck PJ, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285-2293. doi:10.2337/dc10-1303
CR  - Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol. 2012;11(6):521-534. doi:10.1016/S1474-4422(12)70065-0
CR  - Dyck PJ, Kratz KM, Karnes JL, et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology. 1993;43(4):817-824. doi:10.1212/WNL.43.4.817
CR  - Al-Geffari M. Correlation between diabetic neuropathy, retinopathy and nephropathy, and serum levels of vitamin D, HbA1c and lipids in Saudi Arabia. Int J Diabetes Dev Ctries. 2012;32(2):77-82. doi:10.1007/s13410-012-0075-9
CR  - Malik RA, Tesfaye S, Newrick PG, et al. Sural nerve pathology in diabetic patients with minimal but progressive neuropathy. Diabetologia. 2005; 48(3):578-585. doi:10.1007/s00125-005-1663-5
UR  - https://dergipark.org.tr/tr/pub/jompac/issue//1764959
L1  - https://dergipark.org.tr/tr/download/article-file/5153772
ER  -