TY  - JOUR
T1  - Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler
AU  - Topal, Tuğba
AU  - Uzun, Zehra Ece
PY  - 2025
DA  - November
Y2  - 2025
DO  - 10.63716/guffd.1768168
JF  - Gazi Üniversitesi Fen Fakültesi Dergisi
JO  - GÜFFD
PB  - Gazi Üniversitesi
WT  - DergiPark
SN  - 2757-5543
SP  - 343
EP  - 374
VL  - 6
IS  - 2
LA  - tr
AB  - Son yıllarda, immün hücrelerin tümör organoidleri ile birlikte kültürlenmesine yönelik artan bir ilgi bulunmaktadır. Bu yaklaşım, tümörler ile immün sistem arasındaki karmaşık etkileşimlere dair önemli bilgiler elde edilmesini sağlamıştır. Bu çalışmada, tümör mikro çevresi içerisinde yer alan immün hücrelerle olan etkileşimlerin modellenmesine yönelik olarak geliştirilen tümör–immün sistem hücresi organoidlerine dair mevcut gelişmeler ele alınmaktadır. Tümörün oluşumu, tümör mikro çevresinin temel bileşenleri ve bu çevrede yer alan başlıca immün hücre türleri hakkında genel bir çerçeve sunulmuştur. Özellikle hücre dışı matriksin biyokimyasal ve mekanik özelliklerinin; hücreler arası sinyalleşme, hücre göçü ve immün hücrelerin tümöre erişimi üzerindeki etkileri değerlendirilmektedir. Üç boyutlu kültür yöntemleriyle oluşturulan organoid modellerin geliştirilmesi, hastadan türetilmiş örneklerin kullanımı ve organ-on-a-chip gibi ileri teknolojilere dayalı yaklaşımlar sayesinde, tümör–immün sistem etkileşimlerinin daha fizyolojik koşullarda modellenmesi mümkün hale gelmektedir. Son olarak, bu modellerin klinik araştırmalarda kullanımı, tümör biyolojisinin anlaşılmasına katkıları ve gelecekteki potansiyel uygulama alanları tartışılmaktadır.
KW  - Tümör mikroçevresi
KW  - Çip üzerinde organoid teknolojisi
KW  - Hücre dışı matris.
KW  - Tümör mikroçevresi
KW  - Organoid
KW  - Biyomedikal Muhendisligi
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