TY  - JOUR
T1  - Clinical Markers Predicting Mortality in Patients Receiving Renal Replacement Therapy in the Intensive Care Unit: A One-Year Retrospective Study
TT  - Yoğun Bakım Ünitesinde Renal Replasman Tedavisi Alan Hastalarda Mortaliteyi Öngören Klinik Belirteçler: Bir Yıllık Retrospektif Çalışması
AU  - Alparslan, Volkan
AU  - Kutlu, Samet
AU  - Güler, Özlem
AU  - Ergül, Metin
AU  - İzgin Avcı, İpek
AU  - Baykara, Nur
AU  - Kuş, Alparslan
PY  - 2025
DA  - September
Y2  - 2025
DO  - 10.30934/kusbed.1768253
JF  - Kocaeli Üniversitesi Sağlık Bilimleri Dergisi
JO  - KOU Sag Bil Derg
PB  - Kocaeli Üniversitesi
WT  - DergiPark
SN  - 2149-8571
SP  - 171
EP  - 176
VL  - 11
IS  - 3
LA  - en
AB  - Objective: Acute kidney injury (AKI) necessitating continuous renal replacement therapy (CRRT) is linked to elevated mortality rates in the intensive care unit (ICU).  Finding prognostic markers affects each person's care are still very important. The objective of this study was to determine clinical and biochemical predictors of intensive care unit mortality in patients undergoing CRRT.Methods: This retrospective single-center study encompassed 130 adult ICU patients who underwent CRRT from January 2024 to January 2025. For the mortality analysis, patients were divided into two groups: surviving and exitus. For the secondary analysis, they were divided into two groups: early CRRT and late CRRT, based on when they started.Results: The mortality rate in the ICU was 83.8% (n=109).  In multivariable logistic regression, a higher SOFA score (OR: 2.18; 95% GA: 1.38–3.45; p=0.001), increased serum creatinine (OR: 0.59; 95% GA: 0.36–0.94; p=0.029), levels were independently linked to mortality.  There was no significant difference in mortality between the early (57.7%) and late (42.3%) CRRT initiation groups (p>0.05).  The late group, on the other hand, stayed in the ICU and the hospital for a lot longer and got more Prismocal solution (p
KW  - Renal replacement therapy
KW  - acute kidney injury
KW  - intensive care unit
KW  - sepsis-associated AKI
KW  - critical care outcomes
KW  - mortality
N2  - Amaç: Akut böbrek hasarı (ABH), yoğun bakımda  yüksek mortalite ile ilişkilidir. Yoğun bakımda akut böbrek hasarının tedavisinde sürekli renal replasman tedavisi (SRRT) uygulanır. Mortalite için prognostik belirteçlerin saptanması ve SRRT’nin erken veya geç başlanmasının hasta bakımına etkisinin belirlenmesi kritik öneme sahiptir. Çalışmamızın amacı SRRT alan YBÜ hastalarında mortaliteyi öngören klinik ve biyokimyasal belirleyicileri incelemek ve erken ile geç SRRT başlama gruplarının sonuçlarını karşılaştırmaktır.Yöntem: Bu retrospektif, tek merkezli çalışmaya Ocak 2024–Ocak 2025 tarihleri arasında YBÜ’de SRRT uygulanan 130 erişkin hasta dahil edildi. Demografik veriler, hastalık şiddet skorları (SOFA ve APACHE II), laboratuvar değerleri ve SRRT başlama zamanı incelendi. Mortalite analizinde hastalar yaşayanlar ve ölenler olarak iki gruba ayrıldı. İkincil analizde ise başlama zamanına göre erken ve geç başlanan SRRT grupları karşılaştırıldı.Bulgular: Mortalite oranı %83,8 (N=109) idi. Çok değişkenli lojistik regresyon analizinde yüksek SOFA skoru (OR: 2,18; %95 GA: 1,38–3,45; p=0,001), artmış serum kreatinin düzeyi (OR: 0,59; %95 GA: 0,36–0,94; p=0,029), düşük trombosit sayısı, hipoalbüminemi, yüksek INR ve CRP düzeyleri mortalite ile bağımsız olarak ilişkili bulundu. Erken (%57,7) ve geç (%42,3) SRRT başlama grupları arasında mortalite açısından anlamlı fark yoktu (p>0,05). Geç gruptaki hastalar, erken gruba kıyasla daha uzun süre YBÜ ve hastanede yatış gerektirdi ve daha fazla Prismocal solüsyonu aldı (p
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UR  - https://doi.org/10.30934/kusbed.1768253
L1  - https://dergipark.org.tr/tr/download/article-file/5168194
ER  -