@article{article_1770313, title={Association between glucose-to-lymphocyte ratio and hematological parameters, delivery timing, and neonatal outcomes in pregnancies complicated by preterm premature rupture of membranes}, journal={Journal of Medicine and Palliative Care}, volume={6}, pages={603–608}, year={2025}, author={Çayönü Kahraman, Neval and Akın, Furkan and Çelen, Şevki and Çağlar, Ali}, keywords={Fetal membranların erken rüptürü, Glukoz, Lenfositler, biyobelirteçler, gebelik sonuçları, infant, yenidoğan}, abstract={Aims: To evaluate the diagnostic significance of the glucose/lymphocyte ratio (GLR) of preterm premature rupture of membranes (PPROM) and its prognostic ability in predicting adverse neonatal outcomes. Methods: A retrospective assessment was performed on 321 pregnant women who delivered at a tertiary center between January 2023 and January 2025. The study included 156 women diagnosed with PPROM at a gestational age of ≤34+6 weeks. The control group comprised 165 women without PPROM, matched for maternal age, body-mass index (BMI) and gestational week. A poor prognosis was defined as neonatal intensive care unit (NICU) admission, 5-minute APGAR score <7, respiratory distress syndrome (RDS), or neonatal sepsis. GLR, glucose, lymphocyte, and albumin levels were obtained from laboratory data. Results: No significant difference in GLR was observed between the PPROM and control groups (p>0.05). GLR values remained consistent across latency periods ( <72 and ≥72 hours). However, GLR was significantly higher in neonates with poor prognosis (50.9 vs. 41.3, p=0.016). ROC analysis revealed an AUC of 0.621 for GLR (cut-off: 42.6; sensitivity 64.6%, specificity 56%). The AUC for lymphocyte count was 0.619, and for gestational age at diagnosis 0.799, the latter being the strongest predictor. In multivariate logistic regression, gestational age at diagnosis emerged as the only independent predictor of adverse neonatal outcomes (OR=0.61, 95% CI: 0.50–0.74, p <0.001). Conclusion: GLR is not useful for diagnosing PPROM but may serve as a prognostic marker for neonatal outcomes. Gestational age at diagnosis remains the strongest determinant of prognosis.}, number={5}, publisher={MediHealth Academy Yayıncılık}