TY  - JOUR
T1  - Inflammatory indices in hypertensive hemodialysis patients: clinical  implications of MPV and MPVLR
TT  - Hemodiyaliz hastalarında hipertansiyon: inflamatuar, hematolojik ve biyokimyasal değişiklikler ile MPV ve MPVLR’nin klinik önemi
AU  - Bulut Arıkan, Funda
AU  - Öztürk, Hakkı
PY  - 2025
DA  - October
Y2  - 2025
JF  - Journal of Medicine and Palliative Care
JO  - J Med Palliat Care / JOMPAC / Jompac
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2717-7505
SP  - 569
EP  - 574
VL  - 6
IS  - 5
LA  - en
AB  - Aims: Hemodialysis is marked by persistent activation of inflammatory pathways, leading to immune dysregulation and increased cardiovascular morbidity and mortality. Hypertension is highly prevalent among these patients, with growing evidence implicating systemic inflammation and immune mechanisms in its development. This study aimed to evaluate the influence of hypertension on systemic inflammatory and immune-inflammatory indices, as well as hematological and biochemical parameters, in hemodialysis.Methods: This retrospective multicenter study was conducted with 223 patients receiving hemodialysis. Patients were divided into hypertensive (n=90) and normotensive (n=133) groups. Systemic immune-inflammatory indices, including SII, SIRI, PIV, NLR, LMR, PLR, and MPVLR, were calculated. Hematological and biochemical parameters were comprehensively analyzed. Diagnostic performance of biomarkers was assessed using receiver operating characteristic (ROC) curve analysis.Results: Hypertensive hemodialysis patients showed significantly higher MPVLR (p=0.033) and MPV (p=0.039), along with reduced lymphocyte counts (p=0.002), hematocrit (p=0.021), and serum calcium levels (p=0.021) compared with normotensive patients. In sex-stratified analyses, females had higher SII, PIV, MPVLR, and lipid levels, while sodium and ALT were lower than in males (all p
KW  - Hypertension
KW  - hemodialysis
KW  - immune-inflammatory indices
KW  - hematological markers
KW  - biochemical marker
N2  - Amaç: Hemodiyaliz, kalıcı inflamatuar yolakların aktivasyonu ile karakterizedir; bu durum immün disfonksiyon ve artmış kardiyovasküler morbidite ve mortaliteye yol açmaktadır. Hipertansiyon, bu hastalar arasında oldukça yaygındır ve giderek artan kanıtlar, sistemik inflamatuar ve immün mekanizmaların hipertansiyon gelişiminde rol oynadığını göstermektedir. Bu çalışma, hipertansiyonun hemodiyaliz hastalarında sistemik inflamatuar ve immün-inflamatuar indeksler ile hematolojik ve biyokimyasal parametreler üzerindeki etkisini değerlendirmeyi amaçlamıştır.Yöntemler: Bu retrospektif çok merkezli çalışma, hemodiyaliz uygulanan 223 hasta ile gerçekleştirilmiştir. Hastalar hipertansif (n=90) ve normotansif (n=133) gruplar olarak sınıflandırılmıştır. SII, SIRI, PIV, NLR, LMR, PLR ve MPVLR dahil olmak üzere sistemik immün-inflamatuar indeksler hesaplanmıştır. Hematolojik ve biyokimyasal parametreler kapsamlı bir şekilde analiz edilmiştir. Biyobelirteçlerin tanısal performansı, alıcı işletim karakteristikleri (ROC) eğrisi analizi ile değerlendirilmiştir.Bulgular: Hipertansif hemodiyaliz hastalarında, normotansif hastalara kıyasla MPVLR (p=0,033) ve MPV (p=0,039) anlamlı olarak yüksek bulunmuş; lenfosit sayısı (p=0,002), hematokrit (p=0,021) ve serum kalsiyum düzeyleri (p=0,021) ise düşük bulunmuştur. Cinsiyete göre yapılan analizlerde, kadınlarda SII, PIV, MPVLR ve lipid düzeyleri daha yüksek, sodyum ve ALT ise erkeklere göre daha düşük bulunmuştur (tüm p
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UR  - https://dergipark.org.tr/tr/pub/jompac/issue//1773774
L1  - https://dergipark.org.tr/tr/download/article-file/5194038
ER  -