TY  - JOUR
T1  - Clinicopathologic profile of synchronous tumors in patients undergoing surgery for gynecologic malignancy: a retrospective single-center study
TT  - Jinekolojik malignite nedeniyle cerrahi uygulanan hastalarda senkron tümörlerin klinikopatolojik profili: retrospektif tek merkezli çalışma
AU  - Sözen, Işık
AU  - Şahin, Gözde
AU  - Karabudak, Can Berk
AU  - Sharip Kyzy, Aidana
AU  - Aksoy, İlayda
AU  - Öner, Yahya Özgün
AU  - Kayan, Başak Özge
AU  - Benli Tanrıkulu, Fatma
AU  - Çiftpınar, Tolga
AU  - Temel, İlkbal
PY  - 2025
DA  - October
Y2  - 2025
JF  - Journal of Medicine and Palliative Care
JO  - J Med Palliat Care / JOMPAC / Jompac
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2717-7505
SP  - 551
EP  - 556
VL  - 6
IS  - 5
LA  - en
AB  - Aims: This study aimed to characterize tumor types and clinicopathological features of synchronous tumors in women operated for gynecologic malignancies.Methods: This retrospective, single-center study included 20 consecutive patients with a pathological diagnosis of synchronous tumors. Patient demographics, HPV/cytology findings, surgical procedures, histopathological features, treatment modalities, and early outcomes (recurrence and mortality) were collected and analyzed. Results: Mean age was 60.3 years and mean BMI was 31.6 kg/m². Hypertension and diabetes were each present in 35%. Most were HPV-negative (90%); cytology was negative in 65% (abnormalities: ASC-US 20%, ASC-H 5%, HSIL 10%). Synchronous endometrial and ovarian carcinoma (SEOC) was observed in 80% of the patients. The majority of patients had endometrioid adenocarcinoma (EAC). Among SEOC patients, 62.5% had stage I–II tumors. In these cases, histological concordance between synchronous tumors was 62.5%, while staging concordance was 75%.Conclusion: SEOC predominated with high histologic concordance between synchronous tumors. Although SEOC is typically detected at an early stage, there was significant concordance between synchronous tumors in terms of both histology and staging.
KW  - Synchronous tumors
KW  - endometrial cancer
KW  - ovarian cancer
KW  - endometrioid adenocarcinoma
KW  - serous carcinoma
N2  - Amaç: Bu çalışmanın amacı jinekolojik maligniteler nedeniyle ameliyat edilen kadınlarda senkron tümörlerin türlerini ve klinikopatolojik özelliklerini tanımlamaktı.Yöntemler: Bu retrospektif tek merkezli çalışmaya patolojik olarak eş zamanlı tümör tanısı almış ardışık 20 hasta dahil edildi. Hastaların demografik verileri, HPV/sitoloji bulguları, cerrahi prosedürler, histopatolojik bulguları, tedavi tipleri ve erken dönem sonuçları (nüks, mortalite) incelendi ve analiz edildi.Bulgular: Ortalama yaş 60,3 yıl ve ortalama BKİ 31,6 kg/m² idi. Hipertansiyon ve diyabet oranı her biri için %35 idi. Çoğu hastada HPV negatifti (%90); sitoloji %65'inde negatifti (anormallikler: ASC-US %20, ASC-H %5, HSIL %10). Hastaların %80'inde senkron endometrial ve over karsinomu (SEOC) gözlendi. Hastaların çoğunda endometrioid adenokarsinom vardı. SEOC hastaların %62,5'inde evre I-II tümörler vardı ve bu vakalarda tümörler arasındaki histolojik uyum %62,5 evreleme uyumu %75 idi.Sonuç: SEOC, senkron tümörler arasında yüksek histolojik uyumla ön plana çıkmıştır. SEOC genellikle erken evrede tespit edilse de, hem histoloji hem de evreleme açısından senkron tümörler arasında önemli bir uyum vardı.
CR  - Hao L, Zhang L, Xu C, Jiang M, Zhu G, Guo J. Multiple synchronous primary malignant neoplasms: a case report and literature review. Oncol Lett. 2023;26(4):428. doi:10.3892/ol.2023.14014
CR  - Ayhan A, Yalcin OT, Tuncer ZS, Gurgan T, Kucukali T. Synchronous primary malignancies of the female genital tract. Eur J Obstet Gynecol Reprod Biol. 1992;45(1):63-66. doi:10.1016/0028-2243(92)90195-5
CR  - Yang EJ, Lee JH, Lee AJ, et al. Multiple primary malignancies in patients with gynecologic cancer. J Clin Med. 2021;11(1):115. doi:10.3390/jcm 11010115
CR  - Narin MA, Karalok A, Basaran D, et al. Coexisting primary cancers of endometrium and ovary: experience of single institution. Int J Hematol Oncol. 2015;35(1):172-177. doi:10.4999/uhod.151002
CR  - Monist M, Lewkowicz D, Pietak P, Pilewska-Kozak A, Man YG, Semczuk A. Synchronously occurring endometrioid carcinomas of the uterine corpus and uterine cervix preceded by different precancerous lesions: a case study and a literature review. Pathol Res Pract. 2023;245:154452. doi:10.1016/j.prp.2023.154452
CR  - Gan W, Bian C. The research progress on synchronous endometrial and ovarian carcinoma. Front Oncol. 2023;13:1291602. doi:10.3389/fonc. 2023.1291602
CR  - Li L, Yao M, Li L, Shi S, Song Y. Synchronous endometrial/cervical and ovarian/fallopian tube carcinoma: a genome-wide mutation analysis. J Pathol Clin Res. 2025;11(5):e70040. doi:10.1002/2056-4538.70040
CR  - Lim YK, Padma R, Foo L, et al. Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study. J Gynecol Oncol. 2011;22(4):239-243. doi:10.3802/jgo.2011. 22.4.239
CR  - Takeda T, Tsuji K, Banno K, et al. Screening for Lynch syndrome using risk assessment criteria in patients with ovarian cancer. J Gynecol Oncol. 2018;29(3):e29. doi:10.3802/jgo.2018.29.e29
CR  - Gungor T, Kanat-Pektas M, Ustunyurt E, Mollamahmutoglu L. Synchronous primary tumors of the female genital tract: a single center experience. Arch Gynecol Obstet. 2009;279(5):667-672. doi:10.1007/s00404-008-0800-7
CR  - AlHilli MM, Dowdy SC, Weaver AL, et al. Incidence and factors associated with synchronous ovarian and endometrial cancer: a population-based case-control study. Gynecol Oncol. 2012;125(1):109-113. doi:10.1016/j.ygyno.2011.12.444
CR  - Herrinton LJ, Voigt LF, Weiss NS, Beresford SA, Wingo PA. Risk factors for synchronous primary endometrial and ovarian cancers. Ann Epidemiol. 2001;11(8):529-533. doi:10.1016/s1047-2797(01)00237-x
CR  - Khoiwal K, Gaurav A, Tiwari S, Chaturvedi J, Singh A. Synchronous primary malignancy of female genital tract: a report of two cases and review of literature. J Midlife Health. 2019;10(1):51-54. doi:10.4103/jmh.JMH_138_18
CR  - Salvo G, Odetto D, Pareja R, Frumovitz M, Ramirez PT. Revised 2018 International Federation of Gynecology and Obstetrics (FIGO) cervical cancer staging: a review of gaps and questions that remain. Int J Gynecol Cancer. 2020;30(6):873-878. doi:10.1136/ijgc-2020-001257
CR  - Prat J, Oncology FCoG. Staging classification for cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet. 2014;124(1):1-5. doi:10.1016/j.ijgo.2013.10.001
CR  - Singh N. Synchronous tumours of the female genital tract. Histopathology. 2010;56(3):277-285. doi:10.1111/j.1365-2559.2009.03367.x
CR  - Soliman PT, Slomovitz BM, Broaddus RR, et al. Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases. Gynecol Oncol. 2004;94(2):456-462. doi:10.1016/j.ygyno.2004. 05.006
CR  - Kobayashi Y, Nakamura K, Nomura H, et al. Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers. Int J Gynecol Cancer. 2015;25(3):440-446. doi:10.1097/IGC. 0000000000000377
CR  - Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E. Endometrial cancer. Lancet. 2016;387(10023):1094-1108. doi:10.1016/S0140-6736(15) 00130-0
CR  - Jain V, Sekhon R, Pasricha S, et al. Clinicopathological characteristics and prognostic factors of synchronous endometrial and ovarian cancers-a single-institute review of 43 cases. Int J Gynecol Cancer. 2017; 27(5):938-946. doi:10.1097/IGC.0000000000000971
CR  - Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE. Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol. 2001;83(2):355-362. doi:10.1006/gyno.2001. 6400
CR  - Debska-Szmich S, Czernek U, Krakowska M, et al. Synchronous primary ovarian and endometrial cancers: a series of cases and a review of literature. Prz Menopauzalny. 2014;13(1):64-69. doi:10.5114/pm.2014. 41084
CR  - Liu Y, Li J, Jin H, Lu Y, Lu X. Clinicopathological characteristics of patients with synchronous primary endometrial and ovarian cancers: a review of 43 cases. Oncol Lett. 2013;5(1):267-270. doi:10.3892/ol.2012.943
CR  - Calmon MS, Lemos FFB, Silva Luz M, et al. Immune pathway through endometriosis to ovarian cancer. World J Clin Oncol. 2024;15(4):496-522. doi:10.5306/wjco.v15.i4.496
CR  - Zhai J, Vannuccini S, Petraglia F, Giudice LC. Adenomyosis: mechanisms and pathogenesis. Semin Reprod Med. 2020;38(2-03):129-143. doi:10.1055/s-0040-1716687
CR  - Martire FG, Costantini E, D'Abate C, et al. Endometriosis and adenomyosis: from pathogenesis to follow-up. Curr Issues Mol Biol. 2025;47(5):298. doi:10.3390/cimb47050298
CR  - Chiang YC, Chen CA, Huang CY, Hsieh CY, Cheng WF. Synchronous primary cancers of the endometrium and ovary. Int J Gynecol Cancer. 2008;18(1):159-164. doi:10.1111/j.1525-1438.2007.00975.x
CR  - Moro F, Leombroni M, Pasciuto T, et al. Synchronous primary cancers of endometrium and ovary vs endometrial cancer with ovarian metastasis: an observational study. Ultrasound Obstet Gynecol. 2019;53(6):827-835. doi:10.1002/uog.20213
CR  - Song T, Seong SJ, Bae DS, et al. Prognostic factors in women with synchronous endometrial and ovarian cancers. Int J Gynecol Cancer. 2014;24(3):520-527. doi:10.1097/IGC.0000000000000073
CR  - Koç N, Arınkan SA, Şahin D, Temizkan O. Synchronous endometrial and ovarian carcinomas; correlation of clinicopathological parameters with recurrence and survival. Haydarpaşa Numune Med J. 2022;62(4):440. doi:10.14744/hnhj.2021.76476
CR  - Wang M, Li Y, Xu J, Xu S, Wu Y. Prognosis of synchronous endometrial and ovarian cancer based on the PROMISE molecular system. Chin Med J (Engl). 2024;137(15):1870-1872. doi:10.1097/CM9.0000000000003062
UR  - https://dergipark.org.tr/tr/pub/jompac/issue//1774720
L1  - https://dergipark.org.tr/tr/download/article-file/5198307
ER  -