TY  - JOUR
T1  - Diabetes Mellituslu Hastalarda Dental İmplantların Biyomekaniği
AU  - Sevinç Gül, Sema Nur
AU  - Naderlou, Faezeh
PY  - 2025
DA  - October
Y2  - 2025
JF  - Avrasya Üniversitesi Sağlık Bilimleri Dergisi
PB  - Avrasya Üniversitesi
WT  - DergiPark
SP  - 31
EP  - 43
VL  - 1
IS  - 1
LA  - tr
AB  - Bu çalışmanın amacı, dental implant başarısında kritik bir rol oynayan osseointegrasyon süreci üzerine diyabetus mellitusun (DM) etkilerini değerlendirmektir. Literatürde yer alan deneysel hayvan çalışmaları ve insanlarda yapılan uzun dönemli klinik araştırmalar incelenerek diyabetin implant stabilitesi, osseointegrasyon ve alveolar kemik iyileşmesi üzerindeki etkileri analiz edilmiştir. Kontrolsüz diyabetik bireylerde periodontal hastalık prevalansı, diş kaybı, oral enfeksiyon insidansı ve yara iyileşmesinde gecikme oranlarının arttığı görülmektedir. Diyabete bağlı osseointegrasyon bozukluklarının temel mekanizmaları arasında hiperglisemiye bağlı kronik inflamasyon, ileri glikasyon son ürünlerinin (AGE) birikimi ve artmış reaktif oksijen türleri (ROS) üretimi öne çıkmaktadır. Bu biyolojik süreçler kemik rezorpsiyonunu artırmakta, kemik oluşumunu azaltmakta ve fibroblast fonksiyonlarını bozarak yara iyileşmesini olumsuz etkilemektedir. Hayvan çalışmalarında diyabetin periodontal rejenerasyon ve osseointegrasyon üzerinde belirgin olumsuz etkileri gösterilmiştir. Ancak insanlarda yapılan uzun dönemli çalışmalarda, diyabetik ve diyabetik olmayan bireyler arasında implant başarısı açısından benzer sonuçlar bildirilmiştir. Diyabet, özellikle kontrolsüz seyrettiğinde osseointegrasyon sürecini olumsuz etkileyebilmekte ve implant başarısını riske atabilmektedir. Ancak mevcut klinik kanıtlar, iyi kontrol edilen diyabetik bireylerde implant tedavisinin başarı oranlarının diyabetik olmayanlarla karşılaştırılabilir olduğunu göstermektedir.
KW  - Osseointegrasyon
KW  - Diyabet
KW  - Dental İmplant
KW  - Biyomekanik
KW  - Stabilite
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L1  - https://dergipark.org.tr/tr/download/article-file/5217160
ER  -