TY  - JOUR
T1  - Decade of Research on the cGAS-STING Pathway in Cancer: A Bibliometric Analysis (2015 – 2025)
TT  - Kanserde cGAS-STING Yolağı Üzerine On Yıllık Araştırma: Bibliyometrik Analiz (2015-2025)
AU  - Üren, Nihal
PY  - 2026
DA  - March
Y2  - 2026
DO  - 10.46871/eams.1779883
JF  - Experimental and Applied Medical Science
JO  - Exp Appl Med Sci
PB  - Gaziantep İslam Bilim ve Teknoloji Üniversitesi
WT  - DergiPark
SN  - 2757-847X
SP  - 22
EP  - 40
VL  - 7
IS  - 1
LA  - en
AB  - Purpose: The cGAS–STING pathway is a central component of the innate immune system by detecting cytoplasmic DNA and initiating antitumor immunity. Due to its involvement in critical biological processes, including inflammation, apoptosis, and autophagy, this pathway has attracted increasing attention as a promising therapeutic target in cancer research. Methods: On May 4, 2025, an extensive search was conducted in the Web of Science Core Collection database using the terms “cGAS-STING Pathway” AND “Cancer.” Publications from 2015 to 2025 were analyzed in terms of citation counts, publication trends over time, countries with the highest output and citations, most cited papers, frequently referenced authors, and the co-occurrence of author keywords. Network visualizations were generated using VOSviewer software. Results: The search identified 827 relevant articles. Annual publication counts showed a steady increase, peaking in 2024. The People’s Republic of China ranked first with 561 publications and 11,946 citations, followed by the United States with 178 publications and 9,957 citations. The majority of articles appeared in high-impact journals, which also published the most highly cited studies in this field. Recent research has increasingly focused on the role and therapeutic potential of the cGAS-STING pathway in cancer treatment. Conclusion: From 2015 to 2025, research on the cGAS–STING pathway in oncology has expanded substantially, with growing emphasis on therapeutic strategies involving innate immunity. These trends reflect heightened scholarly interest in the pathway’s function in cancer immunotherapy and underscore its potential as a promising target for future research and drug development.
KW  - cGAS-STING Pathway
KW  - Cancer
KW  - Web of Science
KW  - Bibliometric Analysis
N2  - Amaç: cGAS-STING yolu, sitoplazmik DNA'yı tespit ederek antitümör bağışıklığını başlatan doğuştan gelen bağışıklık sisteminin merkezi bir bileşenidir. Enflamasyon, apoptoz ve otofaji dâhil olmak üzere kritik biyolojik süreçlerde rol oynaması nedeniyle, bu yolak kanser araştırmalarında umut verici bir terapötik hedef olarak giderek daha fazla ilgi çekmektedir. Yöntem: 4 Mayıs 2025 tarihinde, Web of Science Core Collection veri tabanında “cGAS-STING Pathway” ve “Cancer” terimleri kullanılarak kapsamlı bir arama yapıldı. 2015–2025 yılları arasındaki yayınlar; atıf sayıları, zaman içerisindeki yayın eğilimleri, en çok yayın ve atıf üreten ülkeler, en çok atıf alan makaleler, sık atıf yapılan yazarlar ve anahtar kelimelerinin birlikte kullanıma açısından analiz edildi. Ağ görselleştirmeleri VOSviewer yazılımı kullanılarak oluşturuldu. Bulgular: Arama sonucunda 827 adet ilgili makale bulundu. Yıllık yayın sayılarında düzenli bir artış gözlenmiş olup, en yüksek seviyeye 2024 yılında ulaşılmıştır. Çin Halk Cumhuriyeti, 561 yayın ve 11.946 atıf ile ilk sırada yer alırken, onu 178 yayın ve 9.957 atıf ile Amerika Birleşik Devletleri takip etmiştir. Makalelerin büyük bir kısmı, aynı zamanda bu alandaki en yüksek atıf alan çalışmaları da yayımlayan yüksek etki faktörlü dergilerde yer almıştır. Son dönem araştırmalar giderek artan biçimde cGAS-STING yolağının kanser tedavisindeki rolü ve terapötik potansiyeline odaklanmıştır. Sonuç: 2015–2025 yılları arasında onkolojide cGAS–STING yolağına ilişkin araştırmalar kayda değer biçimde genişlemiş, doğuştan gelen bağışıklığı hedefleyen terapötik stratejilere yönelik ilgi giderek artmıştır. Bu eğilimler, kanser immünoterapisinde bu yolun işlevine yönelik artan akademik ilgiyi yansıtmakta ve gelecekteki araştırmalar ve ilaç geliştirme için umut verici bir hedef olma potansiyelini vurgulamaktadır.
CR  - Allemann. World Health Organization (WHO). Cancer. Available from: https://www.who.int/detail.
CR  - Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2024;74(3):229-63.
CR  - Singh SR, Bhaskar R, Ghosh S, Yarlagadda B, Singh KK, Verma P, et al. Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes. Cancers. 2025;17(7):1082.
CR  - Zaimy MA, Saffarzadeh N, Mohammadi A, Pourghadamyari H, Izadi P, Sarli A, et al. New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles. Cancer Gene Therapy. 2017;24(6):233-43.
CR  - Gan Y, Li X, Han S, Liang Q, Ma X, Rong P, et al. The cGAS/STING Pathway: A Novel Target for Cancer Therapy. Front Immunol. 2021; 12:795401.
CR  - Wang Y, Luo J, Alu A, Han X, Wei Y, Wei X. cGAS-STING pathway in cancer biotherapy. Molecular Cancer. 2020;19(1):136.
CR  - Kwon J, Bakhoum SF. The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer. Cancer Discovery. 2020;10(1):26-39.
CR  - Chen Q, Sun L, Chen ZJ. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing. Nature Immunology. 2016;17(10):1142-9.
CR  - Hopfner K-P, Hornung V. Molecular mechanisms and cellular functions of cGAS–STING signalling. Nature Reviews Molecular Cell Biology. 2020;21(9):501-21.
CR  - Zhou J, Zhuang Z, Li J, Feng Z. Significance of the cGAS-STING Pathway in Health and Disease. International Journal of Molecular Sciences. 2023;24(17):13316.
CR  - Shi X, Wang S, Wu Y, Li Q, Zhang T, Min K, et al. A Bibliometric Analysis of the Innate Immune DNA Sensing cGAS-STING Pathway from 2013 to 2021. Frontiers in Immunology. 2022;Volume 13 - 2022.
CR  - Aria M, Cuccurullo C. bibliometrix: An R-tool for comprehensive science mapping analysis. Journal of informetrics. 2017;11(4):959-75.
CR  - Fu Y-C, Liang S-B, Luo M, Wang X-P. Intratumoral heterogeneity and drug resistance in cancer. Cancer Cell International. 2025;25(1):103.
CR  - Motwani M, Pesiridis S, Fitzgerald KA. DNA sensing by the cGAS–STING pathway in health and disease. Nature Reviews Genetics. 2019;20(11):657-74.
CR  - Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, et al. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 2017;550(7676):402-6.
CR  - Glück S, Guey B, Gulen MF, Wolter K, Kang T-W, Schmacke Niklas A, et al. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence. Nature Cell Biology. 2017;19(9):1061-70.
CR  - Lv M, Chen M, Zhang R, Zhang W, Wang C, Zhang Y, et al. Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell Research. 2020;30(11):966-79.
CR  - Pantelidou C, Sonzogni O, De Oliveria Taveira M, Mehta AK, Kothari A, Wang D, et al. PARP Inhibitor Efficacy Depends on CD8(+) T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer. Cancer Discov. 2019;9(6):722-37.
CR  - Shen J, Zhao W, Ju Z, Wang L, Peng Y, Labrie M, et al. PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness. Cancer Res. 2019;79(2):311-9.
CR  - Jiang M, Chen P, Wang L, Li W, Chen B, Liu Y, et al. cGAS-STING, an important pathway in cancer immunotherapy. J Hematol Oncol. 2020;13(1):81.
CR  - Coquel F, Silva M-J, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, et al. SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature. 2018;557(7703):57-61.
CR  - Zierhut C, Yamaguchi N, Paredes M, Luo JD, Carroll T, Funabiki H. The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019;178(2):302-15.e23.
CR  - Diamond JM, Vanpouille-Box C, Spada S, Rudqvist NP, Chapman JR, Ueberheide BM, et al. Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs. Cancer Immunol Res. 2018;6(8):910-20.
CR  - Li A, Yi M, Qin S, Song Y, Chu Q, Wu K. Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy. J Hematol Oncol. 2019;12(1):35.
CR  - Samson N, Ablasser A. The cGAS–STING pathway and cancer. Nature Cancer. 2022;3(12):1452-63.
CR  - Chabanon RM, Muirhead G, Krastev DB, Adam J, Morel D, Garrido M, et al. PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer. J Clin Invest. 2019;129(3):1211-28.
CR  - Vizioli MG, Liu T, Miller KN, Robertson NA, Gilroy K, Lagnado AB, et al. Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence. Genes Dev. 2020;34(5-6):428-45.
CR  - Reisländer T, Groelly FJ, Tarsounas M. DNA Damage and Cancer Immunotherapy: A STING in the Tale. Mol Cell. 2020;80(1):21-8.
CR  - Grabosch S, Bulatovic M, Zeng F, Ma T, Zhang L, Ross M, et al. Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles. Oncogene. 2019;38(13):2380-93.
CR  - Hong C, Schubert M, Tijhuis AE, Requesens M, Roorda M, van den Brink A, et al. cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers. Nature. 2022;607(7918):366-73.
CR  - Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity. 2014;41(5):830-42.
CR  - Tollefson J. China declared world's largest producer of scientific articles. Nature. 2018;553(7689):390.
CR  - Hu AGZ. Public funding and the ascent of Chinese science: Evidence from the National Natural Science Foundation of China. Research Policy. 2020;49(5):103983.
CR  - Zhu J, Liu W. Comparing like with like: China ranks first in SCI-indexed research articles since 2018. Scientometrics. 2020;124(2):1691-700.
CR  - Zhang C, Chen L. Bibliometric and visualized analysis of global distribution and research frontiers in tumor immune escape. Front Immunol. 2025;16:1586120.
CR  - Zierhut C, Funabiki H. Regulation and Consequences of cGAS Activation by Self-DNA. Trends Cell Biol. 2020;30(8):594-605.
CR  - Lu Z, Fu Q, Sui J, Chang Y, Jin T, Zhang M. Bibliometric and Visualized Analysis of the Current Status on STING Signaling Pathway and Cancer. J Oncol. 2022;2022:5095176.
UR  - https://doi.org/10.46871/eams.1779883
L1  - https://dergipark.org.tr/tr/download/article-file/5222713
ER  -