@article{article_1780950, title={Optic nerve sheath diameter and postoperative cognitive dysfunction after cardiac surgery: a prospective observational study}, journal={Anatolian Current Medical Journal}, volume={7}, pages={847–854}, year={2025}, DOI={10.38053/acmj.1780950}, author={İlhan, Seher and Akbudak, İlknur Hatice and Mete Yıldız, Aslı and Evran, Turan and Demirtaş, Ali and Tütüncüler, Ece and Gönüllü, Edip}, keywords={Kardiyak Cerrahi, Mini Mental Durum Muayenesi, Optik Sinir Kılıfı, Postoperatif Kognitif Disfonksiyon}, abstract={Aims: This study aims to investigate the association between perioperative optic nerve sheath diameter (ONSD), a noninvasive marker of intracranial pressure, and the incidence of postoperative cognitive dysfunction (POCD) on postoperative days 8 and 30 in patients undergoing elective open-heart surgery with cardiopulmonary bypass. Methods: It was designed as a prospective, observational, single-institution study conducted at a tertiary care hospital. Seventy nine adult patients scheduled for elective open-heart surgery using cardiopulmonary bypass were included. Perioperative ONSD measurements were obtained at five predefined time points during the perioperative period. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) preoperatively and on the 8th and 30th postoperative days. POCD was defined as a clinically significant decline in MMSE score based on the Reliable Change Index (RCI), using a test-retest reliability coefficient of 0.95. An RCI <–1.96 indicated POCD. Results: On postoperative day-8, 44 patients (55.7%) developed POCD, and these patients had a significantly higher median age compared to those without POCD (70.0 vs. 66.0 years, p=0.002). By day-30, POCD persisted in only seven patients (8.9%). Lower preoperative cognitive reserve was also significantly associated with the development of POCD (p <0.05). No significant association was found between perioperative ONSD values and POCD on either postoperative day (p>0.05). Conclusion: Perioperative ONSD was not significantly associated with the development of POCD on postoperative days 8 or 30 in patients undergoing elective open-heart surgery. Instead, preoperative cognitive reserve and older age emerged as stronger predictors of POCD, underscoring the importance of baseline cognitive assessment and patient characteristics in evaluating perioperative risk.}, number={6}, publisher={MediHealth Academy Yayıncılık}, organization={Yazarlar, bu çalışmanın herhangi bir mali destek almadığını beyan etmiştir.}