TY  - JOUR
T1  - Free testosterone index and bioavailable testosterone as independent predictors of good coronary collateral circulation in CTO patients
TT  - Kronik total oklüzyonlu hastalarda iyi koroner kollateral dolaşımın bağımsız belirteçleri olarak serbest testosteron indeksi ve biyoyararlanabilir testosteron
AU  - Yıldırım, Abdullah
AU  - Ardıç, Mustafa Lütfullah
AU  - Paçacı, Emre
AU  - Erdoğan, Aslan
AU  - Küçükcan, Akif
AU  - Coşkun, Mükremin
AU  - Sezici, Emre
AU  - Koca, Fadime
AU  - Özkan, Eyüp
AU  - Harbalıoğlu, Hazar
AU  - Genç, Ömer
AU  - Kurt, İbrahim Halil
PY  - 2025
DA  - October
Y2  - 2025
DO  - 10.38053/acmj.1782590
JF  - Anatolian Current Medical Journal
JO  - Anatolian Curr Med J / ACMJ / acmj
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2718-0115
SP  - 810
EP  - 817
VL  - 7
IS  - 6
LA  - en
AB  - Aims: Chronic total occlusion (CTO) represents a clinically important form of coronary artery disease in which collateral circulation plays a critical role in maintaining myocardial perfusion. Although testosterone has been suggested to influence vascular function and angiogenesis, the relationship between androgenic parameters and coronary collateral development remains uncertain.Methods: This cross-sectional case-control study included 230 male patients diagnosed with CTO by coronary angiography. Coronary collateral circulation was graded using the Rentrop classified categorized as good CCF (score 2–3) or bad CCF (score 0–1). Serum levels of total testosterone, free testosterone, SHBG, dehydroepiandrosterone sulfate (DHEAS), and dihydrotestosterone (DHT) were measured, and bioavailable testosterone (BioT) and free testosterone index (FTI) were calculated. Associations between androgenic parameters and collateral circulation were analyzed using correlation analysis, logistic regression, and ROC curve analysis.  Results: Of the study cohort, 142 patients had good CCF and 88 had bad CCF. Patients with good CCF had higher levels of total testosterone (p
KW  - Chronic total occlusion
KW  - coronary collateral circulation
KW  - testosterone
KW  - bioavailable testosterone
KW  - free testosterone 
index
N2  - Arka plan: Kronik total oklüzyon (CTO), koroner arter hastalığının klinik olarak önemli bir formunu temsil eder ve bu durumda kollateral dolaşım, miyokard perfüzyonunun korunmasında kritik rol oynar. Testosteronun vasküler fonksiyon ve anjiyogenezi etkileyebileceği öne sürülmüş olsa da, androjenik parametreler ile koroner kollateral gelişim arasındaki ilişki belirsizliğini korumaktadır.Yöntemler: Bu kesitsel vaka-kontrol çalışmasına koroner anjiyografi ile CTO tanısı konulan 230 erkek hasta dahil edildi. Koroner kollateral dolaşım Rentrop sınıflaması ile değerlendirildi ve iyi (skor 2–3) veya zayıf (skor 0–1) kollateral dolaşım olarak sınıflandırıldı. Serum total testosteron, serbest testosteron, SHBG, dehidroepiandrosteron sülfat (DHEAS) ve dihidrotestosteron (DHT) düzeyleri ölçüldü; biyoyararlanabilir testosteron (BioT) ve serbest testosteron indeksi (FTI) hesaplandı. Androjenik parametreler ile kollateral dolaşım arasındaki ilişkiler korelasyon analizi, lojistik regresyon ve ROC eğrisi analizi ile incelendi.Bulgular: Çalışma popülasyonunda 142 hastada iyi, 88 hastada zayıf kollateral dolaşım saptandı. İyi kollaterali olan hastalarda total testosteron (p
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UR  - https://doi.org/10.38053/acmj.1782590
L1  - https://dergipark.org.tr/tr/download/article-file/5235356
ER  -