@article{article_1785301, title={Novel Nanocarriers For Rosuvastatin Calcium}, journal={Fabad Eczacılık Bilimler Dergisi}, volume={50}, pages={799–820}, year={2025}, DOI={10.55262/fabadeczacilik.1785301}, author={Aykaç, Kadir and Demirel, Müzeyyen}, keywords={Rosuvastatin kalsiyum, nanotaşıyıcılar, oral ilaç uygulaması, biyoyararlanım artışı}, abstract={Rosuvastatin calcium, belonging to the statin drug class, is commonly prescribed for the treatment of hyperlipidemia by lowering levels of low-density lipoprotein (LDL) cholesterol, triglycerides, and apolipoprotein B, while simultaneously increasing high-density lipoprotein (HDL) cholesterol. It has also shown effectiveness in managing conditions such as familial hypercholesterolemia, dyslipidemia, osteoporosis, atherosclerosis, benign prostatic hyperplasia, and Alzheimer’s disease. However, its therapeutic potential is limited due to challenges like poor aqueous solubility, low intestinal absorption, reduced oral bioavailability, and significant first-pass metabolism. One strategy to overcome these issues is the reduction of drug particle size to the nanoscale, which enhances the dissolution rate of poorly water-soluble compounds. Numerous advanced formulation strategies have been explored to improve the solubility and dissolution of such drugs. These include nanocarrier systems, hydrogels, nanogels, amorphous solid dispersions, co-crystals, nanocrystals, liposomes, micronization, polymer-based nanoparticles, solid lipid nanoparticles, supercritical fluid techniques, nanosuspensions, nanoemulsions, surfactants, micellar solubilization, pH adjustment, co-solvents, hydrotropic agents, and cyclodextrin complexes. This review focuses on the development and application of nanocarrier-based systems to improve the solubility, dissolution rate, and overall bioavailability of rosuvastatin calcium. Furthermore, the physicochemical characteristics and pharmacological potential of rosuvastatin calcium in the context of nanocarrier-mediated delivery are discussed.}, number={3}, publisher={FABAD Ankara Eczacılık Bilimleri Derneği}