TY  - JOUR
T1  - Survival Comparison and Clinical Characteristics of Sunitinib and Pazopanib in the Treatment of Metastatic Renal Cell Cancer, Single Center Real-Life Data
AU  - Büyükbayram, Mehmet Emin
AU  - Hannarici, Zekeriya
AU  - Turhan, Aykut
AU  - Çağlar, Alperen Akansel
AU  - Bilici, Mehmet
AU  - Tekin, Salim Başol
PY  - 2025
DA  - October
Y2  - 2025
JF  - Kafkas Journal of Medical Sciences
JO  - KAFKAS TIP BİL DERG
PB  - Kafkas Üniversitesi
WT  - DergiPark
SN  - 2146-2631
SP  - 1
EP  - 6
VL  - 15
IS  - EK-1
LA  - en
AB  - Aim: Renal cell cancer (RCC) is a tumor with increasing incidence and high morbidity and mortality. Our objective was to compare the progression-free survival (PFS) and overall survival (OS), as well as the clinical and demographic characteristics, of patients diagnosed with metastatic RCC at our center who received treatment with either sunitinib or pazopanib.Material and Methods: The study included 39 patients retrospectively. Clinical and demographic characteristics were extracted from patient records and analyzed using IBM Statistical Package for Social Sciences (SPSS) program version 25. Progression-free survival and OS were analyzed using Kaplan-Meier curves.Results: Among the patients, 30 (76.9%) had clear cell pathology, and 33 (84.6%) had undergone surgery, while 6 (15.4%) were diagnosed through biopsy. First-line treatment with sunitinib was initiated in 28 patients (71.8%), whereas pazopanib was administered to 11 patients (28.2%). The median PFS was 25.8 months, and the median OS was 84.3 months for patients who underwent surgery. In patients diagnosed by biopsy, median PFS was 4.2 months, and median OS was 4.7 months. Progression-free survival (p=0.004) and OS (p
KW  - cancer
KW  - operation
KW  - overall survival
CR  - 1. Siegel RL, Miller KD, Jemal A, et al. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30.
CR  - 2. Janzen NK, Kim HL, Figlin RA, et al. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am. 2003;30:843–52.
CR  - 3. Escudier, B.;Porta, C.;Schmidinger, M. et al. ESMO Guidelines Committee. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-updagger. Ann. Oncol. 2019, 30, 706–720.
CR  - 4. Ljungberg, B.;Albiges, L.;Abu-Ghanem, Y. et al. European Association of Urology Guidelines on Renal Cell Carcinoma: T he 2022 Update. Eur. Urol. 2022, 75, 799–810.
CR  - 5. Motzer RJ, Hutson TE, Cella D, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 369:722–731, 2013.
CR  - 6. Motzer RJ, Hutson TE, McCann L, et al. Overall survival in renal-cell carcinoma with pazopanib versus sunitinib. N Engl J Med 370:1769–1770, 2014.
CR  - 7. Escudier B, Porta C, Bono P, et al. Randomized, controlled, double-blind, cross-over trial assessing treatment preference for pazopanib versus sunitinib in patients with metastatic renal cell carcinoma: PISCES Study. J Clin Oncol 32:1412–1418, 2014.
CR  - 8. Lara PN Jr, Villanueva L, Ibanez C, et al. A randomized, openlabel, phase 3 trial of pembrolizumab plus epacadostat versus sunitinib or pazopanib as first-line treatment for metastatic renal cell carcinoma (KEYNOTE-679/ECHO-302). BMC Cancer. 2024;23(Suppl 1):1253.
CR  - 9. Motzer RJ, Russo P. Systemic therapy for renal cell carcinoma. J Urol. 2000;163:408–17.
CR  - 10. Choueiri TK, Motzer RJ. Systemic Therapy for Metastatic Renal-Cell Carcinoma. New Engl J Med. 2017;376:354–66.
CR  - 11. Powles, T.;Albiges, L.;Bex, A. et al. ESMO Guidelines Committee. ESMO Clinical Practice Guideline update on the use of immunotherapy in early stage and advanced renal cell carcinoma. Ann. Oncol. 2021, 32, 1511–1519.
CR  - 12. Deleuze, A.;Saout, J.;Dugay, F. et al. Immunotherapy in Renal Cell Carcinoma: The Future Is Now. Int. J. Mol. Sci. 2020, 21, 2532.
CR  - 13. Lalani AA, Li H, Heng DYC, et al. First-line sunitinib or pazopanib in metastatic renal cell carcinoma: The Canadian experience. Can Urol Assoc J. 2017;11(3–4):112–7.
CR  - 14. Ko JJ, Choueiri TK, Rini BI, et al. First-, second-, third-line therapy for mRHK. Benchmarks for trial design from the IMDC. Br J Cancer 110:1917–1922, 2014.
CR  - 15. Harrison MR, Hirsch BR, George DJ, et al. Real-world outcomes in metastatic renal cell carcinoma: Insights from a Joint Community-Academic Registry. J Oncol Pract 10:e63e72, 2014.
CR  - 16. Achermann C, Stenner F, Rothschild SI. Treatment, outcome and prognostic factors in renal cell carcinoma: A single center study (2000–2010). J Cancer 7:921–927, 2016.
CR  - 17. Climent MA, Munoz-Langa J, Basterretxea-Badiola L, et al. Systematic review and survival metaanalysis of real world evidence on first-line pazopanib for metastatic renal cell carcinoma. Crit Rev Oncol Hematol 121:45–50, 2018.
CR  - 18. Rini BI, Campbell SC, Escudier B. Renal cell carcinoma. Lancet. 2009;373:1119–32.
CR  - 19. Topal A, Sayın S, Gokyer A. ve ark. Real-life data on firstline Sunitinib and Pazopanib therapy in metastatic renal cell carcinoma patients: a single center experience. J BUON. 2021 Jul-Aug;26(4):1628–1634.
CR  - 20. Leibovich BC, Lohse CM, Crispen PL, et al. Histological subtype is an independent predictor of outcome for patients with renal cell carcinoma. J Urol. 2010;183:1309–15.
CR  - 21. Patard JJ, Leray E, Rioux-Leclercq N, et al. Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol. 2005;23:2763–71.
CR  - 22. Motzer RJ, Escudier B, Oudard S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer. 2010;116:4256–65.
CR  - 23. Kim MS, Chung HS, Hwang EC, et al. Efficacy of First- Line Targeted Therapy in Real-World Korean Patients with Metastatic Renal Cell Carcinoma: Focus on Sunitinib and Pazopanib. J Korean Med Sci. 2018;33:e325.
CR  - 24. McKay RR, Kroeger N, Xie W, et al. Impact of bone and liver metastases on patients with renal cell carcinoma treated with targeted therapy. Eur Urol. 2014;65:577–84.
CR  - 25. Wood CG. The role of cytoreductive nephrectomy in the management of metastatic renal cell carcinoma. Urol Clin North Am. 2003;30:581.
CR  - 26. Flanigan RC, Mickisch G, Sylvester R. et al. Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis. J Urol. 2004;171:1071.
CR  - 27. Kassouf W, Sanchez-Ortiz R, Tamboli P. et al. Cytoreductive nephrectomy for metastatic renal cell carcinoma with nonclear cell histology. J Urol. 2007;178(5):1896–900
UR  - https://dergipark.org.tr/tr/pub/kaftbd/issue//1807859
L1  - https://dergipark.org.tr/tr/download/article-file/5348901
ER  -