TY  - JOUR
T1  - Management Strategies for Synchronous Primary Lung Tumors: A Retrospective Two-Centre Study
AU  - Batıhan, Güntuğ
AU  - Yaldız, Demet
AU  - Acar, Arkın
PY  - 2025
DA  - October
Y2  - 2025
JF  - Kafkas Journal of Medical Sciences
JO  - KAFKAS TIP BİL DERG
PB  - Kafkas Üniversitesi
WT  - DergiPark
SN  - 2146-2631
SP  - 51
EP  - 55
VL  - 15
IS  - EK-1
LA  - en
AB  - Aim: Synchronous primary lung tumors are uncommon and diverse clinical entities. Distinguishing them from intrapulmonary metastases is essential for accurate staging, prognosis evaluation, and selecting the right treatment. This study seeks to describe the clinical, radiological, and histopathological features of synchronous primary lung tumors and to aid in the diagnostic and treatment decision-making process.Material and Methods: Between January 2023 and January 2025, patients diagnosed with synchronous primary lung tumors and evaluated at two tertiary centers were retrospectively analyzed. Clinical, radiological, and histopathological data were reviewed, including smoking history, occupational or environmental exposures, and TNM staging. Treatment strategies and follow-up outcomes were recorded.Results: Out of 250 patients undergoing diagnostic or therapeutic interventions for lung cancer during the study period, four patients (1.6%) met the criteria for synchronous primary lung tumors. Detailed case-based analyses highlighted the heterogeneity in histologic subtypes, anatomical locations, and treatment approaches.Conclusion: Synchronous primary lung tumors are rare but clinically significant. Comprehensive clinical evaluation, detailed histopathologic assessment, and individualized management strategies are essential to optimize outcomes.
KW  - Synchronous lung tumors
KW  - multiple primary lung cancers
KW  - surgical management
KW  - personalized therapy
KW  - thoracic oncology.
CR  - 1. Niu N, Zhou L, Zhao J, Ma X, Yang F, Qi W. Sublobar resection versus lobectomy in the treatment of synchronous multiple primary lung cancer. World Journal of Surgical Oncology. 2023;21(1):135.
CR  - 2. Gazdar AF, Minna J D. Multifocal lung cancers--clonality vs f ield cancerization and does it matter?. Journal of the National Cancer Institute. 2009;101(8):541–543.
CR  - 3. Rostad H, Strand TE, Naalsund A, Norstein J. Resected synchronous primary malignant lung tumors: a population-based study. The Annals of Thoracic Surgery. 2008;85(1):204–209.
CR  - 4. Watanabe T, Tanahashi M, Suzuki E, Yoshii N, Tsuchida H, Yobita S, et al. Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?. Thoracic Cancer. 2021;12(22):2996–3004.
CR  - 5. Raju SC, Peters GW, Decker RH, Park HS. Clinical Outcomes and Safety Profile in the Treatment of Synchronous Nonmetastatic Lung Tumors With Stereotactic Body Radiation Therapy. Practical Radiation Oncology. 2022;12(2):e110–e116.
CR  - 6. Martini N, Melamed MR. Multiple primary lung cancers. J T horac Cardiovasc Surg. 1975;70:606–612.
CR  - 7. Stiles BM. Say goodbye to Martini and Melamed: genomic classification of multiple synchronous lung cancers. Journal of T horacic Disease. 2017;9(1):E87-E88.
CR  - 8. Ishikawa Y, Nakayama H, Ito H, Yokose T, Tsuboi M, Nishii T, et al. Surgical treatment for synchronous primary lung adenocarcinomas. The Annals of Thoracic Surgery. 2014;98(6):1983–1988.
CR  - 9. Shen KR, Meyers BF, Larner JM, Jones DR. Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition) . Chest. 2007;132:290S-305S.
CR  - 10. Chen C, Huang X, Peng M, Liu W, Yu F, Wang X. Multiple primary lung cancer: a rising challenge. J Thorac Dis. 2019;11(Suppl 4):523–36.
CR  - 11. Brunelli A, Kim AW, Berger KI, Addrizzo‐Harris DJ. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence‐based clinical practice guidelines. Chest. 2013;143:166–90.
CR  - 12. Wu X, Huang W, Geng T, Wei Y. Next-Generation Sequencing of Synchronous Multiple Primary Lung Cancers in a Patient with Squamous Cell Carcinoma and Small Cell Lung Cancer. OncoTargets and therapy. 2020;13:11621–11626.
CR  - 13. Yang DS, Huang K, Su M, Wang TT, Liu SS, Xu Y, et al. Nextgeneration sequencing revealed synchronous double primary lung squamous carcinoma: a case report. The Journal of International Medical Research. 2021;49(5):3000605211018575.
UR  - https://dergipark.org.tr/tr/pub/kaftbd/issue//1807894
L1  - https://dergipark.org.tr/tr/download/article-file/5349046
ER  -