TY  - JOUR
T1  - Gümüş Nanopartikülle Modifiye Edilmiş Geleneksel Cam İyonomer Simanların Antimikrobiyal Etkinliği: Sistematik Derleme
TT  - Antimicrobial Efficacy of Silver Nanoparticle-Modified Conventional Glass Ionomer Cements: A Systematic Review
AU  - Güçlü, Zeynep Aslı
AU  - Altan, Feyza Nur
PY  - 2026
DA  - April
Y2  - 2026
DO  - 10.34108/eujhs.1814521
JF  - Sağlık Bilimleri Dergisi
PB  - Erciyes Üniversitesi
WT  - DergiPark
SN  - 1018-3655
SP  - 190
EP  - 198
VL  - 35
IS  - 1
LA  - tr
AB  - Nanoteknolojinin diş hekimliğine entegrasyonu yeni bir dönemi başlatmıştır. Nanopartiküllerin eklenmesiyle dental malzemelerin daha üstün özelliklere kavuşmasını hedefleyen çalışmalar yapılmaktadır. Ancak henüz nanopartiküllerin etki mekanizması ve malzemeye etkisi tam olarak ortaya konulmamıştır. Bu sistematik derlemenin amacı, geleneksel cam iyonomer simanlara gümüş nanopartikül ilavesinin antimikrobiyal performansa etkisini nanopartikül konsantrasyonu, morfolojisi ve boyutuna bağlı olarak değerlendirmektir. 2015–2025 yılları arasında PubMed, Scopus ve Web of Science veri tabanlarında yayımlanmış çalışmalar taranmıştır. Dahil edilen çalışmalar gümüş nanopartikül içeren geleneksel cam iyonomer simanların mikroorganizmalar üzerindeki inhibisyon etkisini inceleyen in vitro araştırmaları kapsamaktadır. Çalışmaların büyük çoğunluğunda, antimikrobiyal etkinliğin konsantrasyon ile doğru orantılı olduğu, ancak düşük ilave oranlarının dahi yüksek antimikrobiyal etki oluşturduğu belirlenmiştir. Ayrıca küçük boyutlu ve homojen dağılmış nanopartiküllerin, kümelenmiş veya düzensiz partiküllere kıyasla daha güçlü antimikrobiyal etki gösterdiği saptanmıştır. Klinik uygulamalara yönelik optimal oranların belirlenebilmesi için sitotoksisite ve uzun dönem çalışmalara ihtiyaç duyulmaktadır.
KW  - Antimikrobiyal aktivite
KW  - geleneksel cam iyonomer siman
KW  - gümüş nanopartikül
KW  - sistematik derleme
N2  - The integration of nanotechnology into dentistry has initiated a new era in dental materials research. Numerous studies have aimed to enhance the properties of dental materials through the incorporation of nanoparticles; however, the underlying mechanisms of action and their effects on material performance have not yet been fully elucidated. The aim of this systematic review was to evaluate the effect of silver nanoparticle incorporation into conventional glass ionomer cements on antimicrobial performance, with particular emphasis on nanoparticle concentration, morphology, and size. Studies published between 2015 and 2025 were systematically searched in the PubMed, Scopus, and Web of Science databases. Eligible studies included experimental and in vitro investigations assessing the inhibitory effects of silver nanoparticle–modified conventional glass ionomer cements against microorganisms. The majority of the included studies reported that antimicrobial efficacy was positively correlated with nanoparticle concentration; however, even low incorporation levels were found to yield substantial antimicrobial effects. In addition, smaller and homogeneously dispersed nanoparticles demonstrated stronger antimicrobial activity compared with aggregated or irregularly distributed particles. Further studies addressing cytotoxicity and long-term outcomes are required to determine optimal incorporation ratios for clinical applications.
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UR  - https://doi.org/10.34108/eujhs.1814521
L1  - https://dergipark.org.tr/tr/download/article-file/5378837
ER  -